grant
Cellular Systems Genetic Approaches to Understanding Regulatory Variation
Organization JACKSON LABORATORYLocation BAR HARBOR, UNITED STATESPosted 1 Aug 2019Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY202521+ years oldAddressAdultAdult HumanBiologyBody TissuesCell BodyCell modelCellsCellular modelChromatinChromatin StructureCodeCoding SystemDNADNA SequenceDNA Transposable ElementsDefectDeoxyribonucleic AcidDevelopmentDiathesisDiseaseDisease susceptibilityDisorderEmbryonic TissueFertilizationGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGenesGeneticGenetic DiversityGenetic VariationGenetic studyGenomeGenomicsGoalsHealthIndividualKnowledgeLaboratoriesModelingModernizationModificationMolecularOutcomePhenotypePopulationPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessProductivityProgenitor CellsProtein ModificationRegenerative MedicineRegulationRegulatory ElementReproducibilityResearchResearch ResourcesResourcesRoleShapesStructureSystemTissuesTransposable ElementsVariantVariationadulthoodchromatin modificationcombinatorialdevelopmentaldevelopmental diseasedevelopmental disorderembryo tissueepigenomefertilizationsgenetic approachgenetic strategyimprovedinnovateinnovationinnovativeliability to diseasenovelprogenitor cell expansionprogenitor cell poolprogenitor cell populationprogenitor expansionprogenitor poolprogenitor populationprogramsregeneration potentialregenerative potentialsocial rolestem and progenitor cell expansionstem and progenitor cell populationstem cell expansionstem cell poolstem cell populationstem cellstool
Description preview
PROJECT SUMMARY
The overarching goal of my laboratory is to determine how natural genetic variation influences
chromatin biology, cell fate, and, ultimately, phenotypic diversity. Since most disease-associated variants
occur in regulatory elements rather than coding genes, delineating the role of regulatory variation in normal health
and disease…
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