grant
Cellular Senescence in Trisomy 21 lung disease
Organization LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTERLocation TORRANCE, UNITED STATESPosted 1 Sept 2024Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20250-11 years old2-Phenyl-Benzopyrans2-Phenyl-Chromenes21+ years oldAD dementiaAdultAdult HumanAgingAirway DiseaseAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAutoimmune DiseasesBirthBody TissuesCardiac DiseasesCardiac DisordersCell AgingCell BodyCell Communication and SignalingCell CountCell Cycle ArrestCell NumberCell SenescenceCell SignalingCell-Extracellular MatrixCellsCellular AgingCellular SenescenceCharacteristicsChildChild YouthChildhoodChildren (0-21)Clinical TrialsCraniofacial AbnormalitiesDNA DamageDNA InjuryDasatinibDataDiseaseDisorderDown SyndromeDrugsECMER stressElementsExhibitsExtracellular MatrixFetal LungFibrosisFlavonoidsFragariaGeneralized GrowthGestationGrowthHealth CareHeart DiseasesHospital AdmissionHospitalizationHumanHutchinson-Gilford DiseaseHutchinson-Gilford SyndromeIFNIndividualInflammatoryInterferonsInterventionIntracellular Communication and SignalingLangdon Down syndromeLifeLinkLive BirthLungLung DiseasesLung ParenchymaLung Respiratory SystemLung TissueLung Tissue FibrosisMaintenanceMediatingMedicalMedicationMesenchymalModelingModern ManMongolismMorphologyMuscle TonusNeonatalOxidative StressParturitionPathogenesisPathway interactionsPerinatalPeripartumPharmaceutical PreparationsPhenotypePregnancyPremature Senility SyndromePrimary Senile Degenerative DementiaProgeriaProliferatingPulmonary DiseasesPulmonary DisorderPulmonary FibrosisPulmonary HypertensionQuercetinReplicative SenescenceRoleSamplingSignal TransductionSignal Transduction SystemsSignalingSliceStrawberriesStructure of parenchyma of lungSyndromeTestingTimeTissue GrowthTissuesTracheobronchialTrisomy 21Vulnerable PopulationsWheezingadulthoodairflow limitationairflow obstructionairway limitationairway muscleairway obstructionairway remodelingautoimmune conditionautoimmune disorderautoimmunity diseasebeta-D-Galactosidasebeta-D-Galactoside galactohydrolasebeta-Galactosidasebiological signal transductionbrain cellchromosome 21 trisomychromosome 21 trisomy syndromeclinical relevanceclinically relevantcongenital acromicria syndromecraniofacial anomaliescraniofacial defectscraniofacial malformationdisease of the lungdisorder of the lungdrug/agentendoplasmic reticulum stressfetalfibrosis in the lungfisetinheart disorderhuman fetal lung tissueimmune clearanceimmune eliminationin uteroinfancyinfantileinnovateinnovationinnovativekidskinase inhibitorlac Z Proteinlung disease in neonatal periodlung disease in neonateslung disease in newbornslung disorderlung fibrosislung hypoplasiamitochondrial dysfunctionmorbus Downmuscle toneneonatal lung diseaseneonatal pulmonary diseaseneuralnew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynewborn lung diseasenext generation therapeuticsnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapyobstructed airflowobstructed airwayontogenyparacrinepathwaypediatricperinatal periodperinatal phasepostnatalprematureprematurityprenatalprimary degenerative dementiapseudohypertrophic progressive muscular dystrophypulmonarypulmonary hypoplasiarepairrepairedreplicative agingrespiratory airway obstructionresponsesenescencesenescentsenile dementia of the Alzheimer typesenolyticssenomorphicsenostaticsocial roletherapeutically effectivetrisomy 21 syndromeunbornvulnerable groupvulnerable individualvulnerable peoplewheezeyoungsterβ-D-Galactosidaseβ-D-Galactoside galactohydrolaseβ-Galactosidase
Description preview
SUMMARY
Trisomy 21 (T21) occurs in ~1 in 700 live births resulting in Down Syndrome (DS), where pulmonary
complications are the main cause of hospitalizations in children and adults. These include tracheobronchial
diseases presenting as decreased upper airway muscle tone, tracheobronchial malacia and airway obstruction
with wheezing, particularly…
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