grant
Cellular mechanisms of peptidergic signaling
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 1 Aug 2019Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY2025Absence of pain sensationAbsence of sensibility to painAssayBioassayBiogenic AminesBiological AssayCalciumCalibrationCancersCardiologyCell BodyCell Communication and SignalingCell SignalingCellsChemical DependenceCorpus StriatumCorpus striatum structureDegenerative Neurologic DisordersDevelopmentDiabetes MellitusDigestionDiseaseDisorderDrug AddictionDrug DependenceDrug DependencyEating DisordersEmotionsEndocrineEndocrine Gland SecretionEndocrine systemEndocrine/Metabolic Organ SystemEventFeels no painG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGPCRGastroenterologyGrowth AgentsGrowth FactorGrowth SubstancesHealthHormonal SystemHormonesHumanHuntington ChoreaHuntington DiseaseHuntington'sHuntington's DiseaseHuntingtons DiseaseIntracellular Communication and SignalingLactationMalignant NeoplasmsMalignant TumorMental DepressionMental disordersMental health disordersMetabolic DiseasesMetabolic DisorderMetabolic/Endocrine Body SystemModern ManMolecularMonitorNerve CellsNerve UnitNervous SystemNervous System Degenerative DiseasesNervous System DiseasesNervous System DisorderNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Body SystemNeurologic Degenerative ConditionsNeurologic DisordersNeurologic Organ SystemNeurological DisordersNeuronsNeuropeptidesNeurosciencesNo sensitivity to painOrganism-Level ProcessOrganismal ProcessPainPainfulPathway interactionsPeptide Hormone GenePeptide Signal SequencesPeptidesPhysiologic ProcessesPhysiological ProcessesPhysiologyProteins Growth FactorsPsychiatric DiseasePsychiatric DisorderResearchSignal PathwaySignal PeptideSignal SequencesSignal TransductionSignal Transduction SystemsSignalingSleep DisordersStriate BodyStriatumSynaptic VesiclesTherapeutic HormoneThesaurismosisThyroid DiseasesThyroid Gland DiseaseThyroid Gland DisorderTransmissionWorkanalgesiabiological signal transductionbiological systemscell typedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdepressiondevelopmentaldiabetesendocrine gland/systemfeedinginnovateinnovationinnovativelactatinglactationalmalignancymental illnessmetabolism disorderneoplasm/cancerneural controlneural regulationneurodegenerative illnessneurological diseaseneuromodulationneuromodulatoryneuronalneurophysiologicalneurophysiologyneuroregulationnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathwaypeptide hormonepeptide mimeticpeptide mimicpeptidomimeticsprotein signal sequencepsychiatric illnesspsychological disordersleep diseasessleep dysfunctionsleep illnesssleep problemspatial and temporalspatial temporalspatiotemporalstriatalthyroid disordertransmission process
Description preview
Project Summary
The secretion of growth factors, peptide hormones, neuropeptides and biogenic amines from neurons and
endocrine cells is a tightly-regulated event that drives physiological processes such as feeding, digestion, energy
storage, lactation, emotion and analgesia. Compromised peptide transmitter signaling is implicated in metabolic
and…
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