grant
Cellular basis for cancer treatment related GDF15 expression and the regulation of skeletal muscle fibrosis and neuromuscular integrity.
NIHUS FederalResearch GrantFY20250-11 years old7B4 Antigen7B4 proteinAccelerationAchievementAchievement AttainmentAcuteAddressAdolescentAdolescent YouthAdverse effectsAffectAgeAnimalsAntioncogene Protein p53AttenuatedBiological FunctionBiological ProcessBody WeightBody Weights and MeasuresBrain StemBrainstemCD144 AntigenCancer PatientCancer SurvivorshipCancer TreatmentCancersCell BodyCell Communication and SignalingCell CountCell NumberCell SignalingCellsCellular OncogeneCellular Tumor Antigen P53Chemotherapy and RadiationChemotherapy and/or radiationChildChild YouthChildhoodChildhood Cancer TreatmentChildhood CancersChildren (0-21)ChronicCombined Modality TherapyDataDevelopmentDiagnosisDrug TherapyEatingElderlyEndocrine Gland SecretionEndothelial CellsEventFeeding behaviorsFibrosisFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFood IntakeGDF15GDF15 geneGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGeneralized GrowthGenesGenotoxic StressGoalsGrowthHeterozygoteHigh PrevalenceHindlimbHormonesIatrogenic CancerImageImpairmentImplantIndividualIngestive BehaviorInterventionIntracellular Communication and SignalingIntramuscularKO miceKnock-outKnock-out MiceKnockoutKnockout MiceLeurocristineMIC-1 gene productMIC1Macrophage Inhibitory Cytokine-1MaintenanceMalignant CellMalignant Childhood NeoplasmMalignant Childhood TumorMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant Pediatric NeoplasmMalignant Pediatric TumorMalignant TumorMalignant childhood cancerMediatingMedicalMesenchymal Progenitor CellMesenchymal Stem CellsMesenchymal progenitorMesenchymal stromal/stem cellsMiceMice MammalsMicroscopyMorbidityMorbidity - disease rateMultimodal TherapyMultimodal TreatmentMurineMusMuscleMuscle FibersMuscle TissueMyoneural JunctionMyotubesNAG-1 proteinNAG1NSAID activated gene-1 productNSAID-Activated Protein 1NSAID-Regulated Protein 1Nerve CellsNerve UnitNeural CellNeurocyteNeuromuscular JunctionNeuronsNonsteroidal Anti-Inflammatory Drug-Activated Protein 1Normal TissueNormal tissue morphologyNull MouseOncoprotein p53P53PLABPLAB ProteinPTGF-BetaPTK ReceptorsPediatric Cancer TreatmentPharmacological TreatmentPharmacotherapyPhenotypePhosphoprotein P53Phosphoprotein pp53Placental Bone Morphogenic ProteinPlacental TGF-BetaPopulationProductionProstate Differentiation FactorProtein TP53Proto-OncogenesPublishingRNA SeqRNA sequencingRNAseqRadiationReceptor Protein-Tyrosine KinasesReceptor Tyrosine Kinase GeneRegulationRegulatory ElementReporterResearchRhabdomyocyteRhabdomyosarcomaRoentgen RaysRoleScienceSignal TransductionSignal Transduction SystemsSignalingSkeletal FiberSkeletal MuscleSkeletal Muscle CellSkeletal Muscle FiberSkeletal MyocytesStressSurvival RateSurvivorsTP53TP53 geneTRP53TamoxifenTestingTherapeuticTherapeutic HormoneTherapy Related Malignant NeoplasmTherapy Related Malignant TumorTherapy-Associated CancersTherapy-Related CancerTissue GrowthTranscript Expression AnalysesTranscript Expression AnalysisTransfectionTransmembrane Receptor Protein Tyrosine KinaseTreatment-Associated CancerTreatment-Related CancerTumor Protein p53Tumor Protein p53 GeneTyrosine Kinase Linked ReceptorsTyrosine Kinase ReceptorsVE-CadherinVascular Endothelial CadherinVascular Endothelial Cadherin 1Vascular EndotheliumVincristineVincrystineVoluntary MuscleWeight GainWeight IncreaseX-RadiationX-Ray RadiationX-rayXrayXray irradiationadult youthadvanced ageadverse consequenceadverse outcomeagesanalyze gene expressionanti-cancer therapyattenuateattenuatesbiological adaptation to stressbiological signal transductionbody weight gainbody weight increasec-ONCcadherin 5cancer cellcancer in a childcancer in childrencancer therapycancer-directed therapychemo/radiation therapychemotherapychemotherapy and radiotherapychild with cancerchildhood cancer survivorchildhood malignancychildhood radiationcombination therapycombined modality treatmentcombined treatmentdevelopmentaldrug interventiondrug treatmentfeeding-related behaviorsflow cytophotometryfractionated radiationfrailtygene expression analysisgene expression assaygeriatricgrowth differentiation factor 15heterozygosityimage guidanceimage guidedimagingimprovedindexinginduced Creinducible Creinhibitorinsightjuvenilejuvenile humankidsmalignancymesenchymal stromal cellmesenchymal stromal progenitor cellsmesenchymal-derived stem cellsmid lifemid-lifemiddle agemiddle agedmidlifemouse geneticsmouse modelmulti-modal therapymulti-modal treatmentmulti-modalitymultimodal modelingmultimodalitymurine modelmuscularneoplasm/cancerneuromuscularneuromuscular functionneuronalnovelnutrient intake activityontogenyoxovincaleukoblastinep53 Antigenp53 Genesp53 Tumor Suppressorpediatricpediatric cancerpediatric cancer survivorpediatric malignancypediatric radiationpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsprematureprematurityprotein p53protooncogeneradiation during childhoodradiation effectradiation in childrenradiation or chemotherapyreaction; crisisresponsescRNA sequencingscRNA-seqsenior citizensingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestress responsestress; reactionstressortranscriptional profilingtranscriptome sequencingtranscriptomic sequencingtumor eradicationwt gainx-ray irradiationyoung adultyoung adult ageyoung adulthoodyoungster
Description preview
ABSTRACT
One of the great achievements in medical sciences is the improved survival rate among children diagnosed with
cancer. Although estimates indicate the 5-year survival rate of children diagnosed with a malignancy is near
80%, most of these individuals prior to the age of 40 demonstrate indices of physical limitation normally
associated with…
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