grant
Cellular and molecular regulators of melanocyte regeneration
Organization UNIV OF MASSACHUSETTS MED SCH WORCESTERLocation WORCESTER, UNITED STATESPosted 1 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2025AblationAdoptedAffectAssayAutograftAutoimmune DiseasesAutologous TransplantationAutoregulationAutotransplantB-raf-1BRAFBRAF geneBioassayBiologic ModelsBiological AssayBiological ModelsBlebBlisterBody TissuesBrachydanio rerioBullaBullous LesionCell BodyCell Communication and SignalingCell SignalingCellsCheckpoint inhibitorDanio rerioDataDiseaseDisorderDissectionDrug TherapyDrug resistanceGene ExpressionGene TranscriptionGenesGeneticGenetic TranscriptionHomeostasisHumanHypomelanosisHypopigmentationImmersionImmune checkpoint inhibitorIndividualIntracellular Communication and SignalingKnowledgeLeadLesionLineage TracingMacrophageMaintenanceMalignant MelanomaMapsMeasuresMediatingMelanomaMelanoma CellMethodologyModel SystemModern ManMolecularMφNGFRNGFR geneNatural regenerationPathway interactionsPatientsPb elementPharmacological TreatmentPharmacotherapyPhysiological HomeostasisPopulationProceduresProcessRAFB1RNA ExpressionRecoveryRegenerationResearch ResourcesResistanceResourcesRoleSamplingSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSkinSkin PigmentationStigmatizationSystemTNFRSF16TechniquesTimeTissuesTranscriptionUV Light TherapyUV TreatmentUltraviolet Radiation TherapyUltraviolet TherapyUltraviolet TreatmentVesicationVitiligoZebra DanioZebra FishZebrafishautoimmune conditionautoimmune disorderautoimmunity diseaseautologous graftautotransplantationbiological signal transductioncell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcell typecellular lineage mappingcellular lineage trackingcombinatorialdrug interventiondrug resistantdrug treatmentexperimentexperimental researchexperimental studyexperimentsheavy metal Pbheavy metal leadimmune check point inhibitorinhibitor druginhibitor therapeuticinhibitor therapyinjury to tissueinsightleukodermamelanocytemelanocyte progenitormelanocyte stem cellsnovelp75(NTR)pathwaypatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsprogenitor biologyprogenitor cell biologyprogenitor cell fateprogenitor cell geneprogenitor cell maintenanceprogenitor cell regenerationprogenitor cell self renewalprogenitor fateprogenitor geneprogenitor maintenanceprogenitor regenerationprogenitor self renewalpsychologicpsychologicalregenerateregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissueregenerative cellrepairrepairedresistance to Drugresistantresistant to DrugresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocialsocial rolestem and progenitor biologystem and progenitor cell fatestem and progenitor cell regenerationstem and progenitor cell self renewalstem cell biologystem cell fatestem cell genesstem cell maintenancestem cell regenerationstem cell self renewaltissue injurytissue regenerationtissue regrowthtissue renewaltissue specific regenerationtranscriptomicstumorultraviolet light phototherapyv-raf Murine Sarcoma Viral Oncogene Homolog B1
Description preview
PROJECT SUMMARY:
The proposed studies seek to isolate and characterize melanocyte stem cells (McSCs) as well as identify the
signals and pathways that govern McSC-mediated melanocyte regeneration. McSC gene expression will be
characterized using single-cell RNA sequencing (scRNAseq). In zebrafish we will perform longitudinal
sampling of McSCs…
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