grant
Cellular and Molecular Control of Normal and Disordered Erythropoiesis
Organization FEINSTEIN INSTITUTE FOR MEDICAL RESEARCHLocation MANHASSET, UNITED STATESPosted 15 Feb 2024Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAffectAnemia due to Chronic DisorderBiogenesisBiologyBirthBlood DiseasesBlood erythrocyteBone MarrowBone Marrow Reticuloendothelial SystemCardiac DiseasesCardiac DisordersCausalityCell CycleCell Division CycleDefectDevelopmentDiamond-Blackfan anemiaDiseaseDisorderDysfunctionEconomic BurdenErythrocytesErythrocyticErythroidErythropoiesisEtiologyFetal HbFetal HemoglobinFunctional disorderHb SS diseaseHbFHbSS diseaseHeart DiseasesHematologic DiseasesHematological DiseaseHematological DisorderHemoglobin FHemoglobin S DiseaseHemoglobin sickle cell diseaseHemoglobin sickle cell disorderIMiDImmune modulatory therapeuticInflammationInflammation associated anemiaInflammatoryIslandLengthLifeMarrow erythrocyteModelingMolecularMorbidityMorbidity - disease rateNatureOrigin of LifeParturitionPersonsPhysiopathologyProcessProductionProductivityRed Blood CellsRed CellRegulationResearchRibosomal ProteinsRibosomesRoleSickle Cell AnemiaSteroid ResistanceSteroid ResistantTestingWorkadulthoodanemia of chronic diseaseanemia of inflammationblood corpusclesblood disorderbone marrow failure syndromecausationdevelopmentaldisease causationerythroid developmentfetalfetal form of hemoglobinfetal globinheart disorderimmune modulating agentsimmune modulating drugimmune modulating therapeuticsimmune modulatory agentsimmune modulatory drugsimmunomodulating agentsimmunomodulating drugsimmunomodulator agentimmunomodulator drugimmunomodulator medicationimmunomodulator prodrugimmunomodulator therapeuticimmunomodulatory agentsimmunomodulatory drugsimmunomodulatory therapeuticsmortalityneonatal humannew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathophysiologyprogramssickle cell diseasesickle cell disordersickle diseasesicklemiasocial role
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Project Summary/Abstract
Red cell disorders affect more than 1 billion people worldwide, are a significant cause of morbidity and
mortality and lead to a substantial economic burden. These disorders can result from a decrease in survival or
in production (or both). Our research is focused on erythropoiesis and how this process goes awry in…
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