grant
Cell type-specific neurotensin signaling in methamphetamine use disorder
Organization OKLAHOMA MEDICAL RESEARCH FOUNDATIONLocation OKLAHOMA CITY, UNITED STATESPosted 15 Feb 2026Deadline 30 Nov 2030
NIHUS FederalResearch GrantFY20264-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acidAblationAbstinenceAffectAminalonAminaloneAnimalsAreaAstrocytesAstrocytusAstrogliaAstroproteinAxon TerminalsBehaviorBehavioralBrainBrain Nervous SystemCRE RecombinaseCell BodyCell Communication and SignalingCell NucleusCell SignalingCellsChronicCorpus StriatumCorpus striatum structureCrystal MethCrystal methamphetamineCuesD2 receptorDA NeuronDRD2 ReceptorDREADDsDataDeoxyephedrineDesoxyephedrineDopamineDopamine D2 ReceptorDopamine neuronDrug ExposureDrugsElectrophysiologyElectrophysiology (science)EncephalonEnterobacteria phage P1 Cre recombinaseExhibitsFDA approvedFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFutureGABAGFA-ProteinGFAPGene ModifiedGeneticGleanGliaGlial CellsGlial Fibrillary Acid ProteinGlial Fibrillary Acidic ProteinGlial Intermediate Filament ProteinHumanHydroxytyramineIncubatedIndividualInfusionInfusion proceduresIntakeInterventionIntracellular Communication and SignalingIntravenousInvestigationKnowledgeKolliker's reticulumLearningLigandsLoxP-flanked alleleMETH dependenceMaintenanceMeasuresMediatingMedicationMental DepressionMesencephalonMethamphetamineMethamphetamine dependenceMethamphetamine use disorderMethylamphetamineMiceMice MammalsMid-brainMidbrainMidbrain structureModern ManMurineMusN-MethylamphetamineNerve CellsNerve Impulse TransmissionNerve TransmissionNerve Transmitter SubstancesNerve UnitNeural CellNeurocyteNeurogliaNeuroglial CellsNeuronal TransmissionNeuronsNeurophysiology / ElectrophysiologyNeurotensinNeurotensin ReceptorsNeurotransmittersNon-neuronal cellNonneuronal cellNucleusNucleus AccumbensPathway interactionsPeptidesPharmaceutical PreparationsPopulationPresynaptic Nerve EndingsPresynaptic TerminalsProteinsPsychological reinforcementPublic HealthPublishingReceptor ProteinReinforcementRelapseRewardsRoleSalineSaline SolutionSelf AdministeredSelf AdministrationSignal TransductionSignal Transduction SystemsSignalingSiteSliceStriate BodyStriatumSubstantia NigraSubstantia nigra structureSynaptic BoutonsSynaptic TerminalsSynaptic plasticityTechniquesTestingTherapeuticTimeVentral Tegmental AreaViralVirusWild Type MouseWorkaddiction to methamphetamineantagonismantagonistastrocytic gliaaxon signalingaxon-glial signalingaxonal signalingbacteriophage P1 recombinase Crebiological signal transductioncell typedepressiondesigner receptors exclusively activated by designer drugsdopaminergic neurondrug/agentelectrophysiologicalexperimentexperimental researchexperimental studyexperimentsexposure to methexposure to methamphetamineextracellularflow cytophotometryfloxedfloxed allelegamma-Aminobutyric Acidgene modificationgenetic analysisgenetically modifiedglia signalingglial signalingin vivoinfusionsmethmeth addictionmeth exposuremeth use disordermethamphetamine addictionmethamphetamine exposuremolecular phenotypenerve cementnerve signalingneural signalingneuronalneuronal excitabilityneuronal signalingneurophysiologicalneurophysiologyneurotransmissionnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpars compactapatch clamppatch sequencingpatch-seqpatchseqpathwaypharmacologicprevent relapsepsychostimulant abusepsychostimulant usepsychostimulant use disorderreceptorreinforcerrelapse preventionscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestimulant abusestimulant usestimulant use disorderstriataltooltranscriptomicsuse of stimulantsventral tegmentumwildtype mouseγ-Aminobutyric Acid
Description preview
Methamphetamine (METH) use disorder is chronic and progressive, and currently no therapeutic is approved
by the FDA for its treatment. Dopamine (DA) neurons in the substantia nigra pars compacta (SNc) and ventral
tegmental area (VTA) are necessary for learning associated with drug reinforcers. Our published and preliminary
work highlights a role…
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