grant
Cell State Network-Directed Therapy
Organization CLEMSON UNIVERSITYLocation CLEMSON, UNITED STATESPosted 20 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAddressAffectAnti-Cancer AgentsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsAssayAstrocytesAstrocytusAstrogliaAutoregulationBBB penetrationBar CodesBehaviorBioassayBiological AssayBody TissuesBrain NeoplasiaBrain NeoplasmsBrain TumorsCancer DrugCancer TreatmentCancersCell BodyCell CommunicationCell Culture TechniquesCell CycleCell Division CycleCell InteractionCell modelCell-to-Cell InteractionCellsCellular modelCerebral endotheliumCo-cultureCocultivationCocultureCoculture TechniquesCombined Modality TherapyComputer ModelsComputerized ModelsDataData SetDeath RateDevelopmentDoseDrug CombinationsDrug TargetingDrug resistanceDrugsEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEventFDA approvedFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGeneralized GrowthGeneticGlial Cell TumorsGlial NeoplasmGlial TumorGlioblastomaGliomaGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaGrowthHeterogeneityHomeostasisHumanHybridsImageImmunofluorescenceImmunofluorescence ImmunologicKnowledgeLeast SquaresLeast-Squares AnalysesLeast-Squares AnalysisMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMeasurementMediatingMedicationMesenchymalMethodsModelingModern ManModernizationMonitorMultimodal TherapyMultimodal TreatmentNPCNeoplastic Disease Chemotherapeutic AgentsNerve CellsNerve UnitNeural CellNeural Stem CellNeurocyteNeuroglial NeoplasmNeuroglial TumorNeuronsNuclear Pore ComplexPDX modelPathway interactionsPatient derived xenograftPatientsPatternPharmaceutical PreparationsPhysical assessmentPhysiological HomeostasisPopulationPopulation GrowthProbabilityProteinsPublishingRNA SeqRNA sequencingRNAseqRegimenResistanceSortingSystemTemodalTemodarTestingTimeTissue GrowthTissuesTumor CellTumor-Specific Treatment AgentsUpdateWorkanti-canceranti-cancer druganti-cancer therapyastrocytic gliabarcodeblood-brain barrier penetrationbloodbrain barrier penetrationbrain endotheliumcancer cellcancer drug resistancecancer therapycancer-directed therapycell culturecell culturescell typechemotherapychip modelchip systemclinical relevanceclinically relevantcombination therapycombined modality treatmentcombined treatmentcomputational modelingcomputational modelscomputer based modelscomputer based predictioncomputerized modelingcortical endotheliumdesigndesigningdevelopmentaldiscrete timedrug resistantdrug sensitivitydrug-sensitivedrug/agentepigeneticallyexperimentexperimental researchexperimental studyexperimentsflexibilityflexibleflow cytophotometryglial-derived tumorglioblastoma multiformeglioma cell lineglobal gene expressionglobal transcription profileimagingin vivointervention designkinase inhibitorlive cell imagelive cell imaginglive cellular imagelive cellular imagingmachine learning based methodmachine learning methodmachine learning methodologiesmalignancymarkov modelmethazolastonemonolayermortality ratemortality ratiomulti-modal therapymulti-modal treatmentneoplasm/cancerneoplastic cellnerve stem cellnetwork modelsneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurogenic progenitorsneurogenic stem cellneuroglia neoplasmneuroglia tumorneuron progenitorsneuronalneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitoroligodendrocyte precursoroligodendrocyte precursor celloligodendrocyte progenitoroligodendrocyte stem cellon a chipon chipontogenyorgan chiporgan on a chiporgan on chippathwaypatient derived xenograft modelphospho-proteomicsphosphoproteomicspredictive modelingprogenitor and neural stem cellsprogramsresistance mechanismresistance to Drugresistance to cancer drugsresistantresistant mechanismresistant to Drugresistant to cancer drugsresponsescRNA sequencingscRNA-seqscreeningscreeningssingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsspongioblastoma multiformestandard of caretemozolomidetheoriestherapy designthree dimensionaltranscriptometranscriptome sequencingtranscriptomic sequencingtreatment designtumortumor chiptumor on a chiptumor on chiptumors in the brain
Description preview
ABSTRACT—Cell State Network-Directed Therapy
Drug resistance is a significant challenge in cancer therapy and has historically been addressed from “one step
behind”, whereby drug(s) become progressively ineffective, resistance mechanism(s) are studied, and then
different drug(s) are used. While genetic and other resistance pathways are…
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