grant
Cell-Specific Transcriptional Programs in Cardiac Allograft Vasculopathy
Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2025ATAC sequencingATAC-seqATACseqAcademic Medical CentersAddressAdvisory CommitteesAgeAnimal ModelAnimal Models and Related StudiesArchitectureAssayAssay for Transposase-Accessible Chromatin using sequencingAwardBioassayBioinformaticsBiological AssayBiological MarkersBiologyBiopsyBiopsy SampleBiopsy SpecimenBloodBlood PlasmaBlood Reticuloendothelial SystemBlood leukocyteBody TissuesCardiacCardiac DiseasesCardiac DisordersCardiac TransplantationCardiac VolumeCardiac arteryCausalityCause of DeathCell BodyCellsCessation of lifeChromatinChronicClinicalCollaborationsCommunicationConsentCoronaryCoronary AngiographyCoronary arteryDataDeathDevelopmentDevelopment PlansDiffuseDiseaseDisorderEndotheliumEngineering / ArchitectureEnsureEtiologyEventEvolutionExhibitsExpression SignatureFoundationsFreezingFundingFutureGenderGene Action RegulationGene Expression ProfileGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenesGenetic TranscriptionGoalsGraft SurvivalHeartHeart DiseasesHeart GraftingHeart Muscle tissueHeart TransplantationHeart VolumeHeart arteryHeart failureHeterograftHeterologous TransplantationHistologicHistologicallyHumanImmuneImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImmunologyIndividualInflammatoryInterdisciplinary ResearchInterdisciplinary StudyIschemiaKnowledgeLesionLeukocytesLeukocytes Reticuloendothelial SystemMachine LearningManualsMarrow leukocyteMentorsMentorshipMessenger RNAMicrovascular DysfunctionModern ManMultidisciplinary CollaborationMultidisciplinary ResearchMyocardialMyocardial tissueNuclearNuclear RNAObstructionPBMCPathogenesisPatientsPatternPeripheral Blood Mononuclear CellPhasePhenotypePhysiciansPlasmaPlasma SerumPositionPositioning AttributePreventionProbabilistic ModelsProbability ModelsProcessProgressive DiseaseProspective StudiesPublishingRNA ExpressionRNA SeqRNA sequencingRNAseqRegulationResearchResearch DesignReticuloendothelial System, Serum, PlasmaScientistSingle-Nucleus SequencingStatistical ModelsStudy TypeTask ForcesTechniquesTimeTissuesTrainingTranscriptionTranslational ResearchTranslational ScienceTransplant RecipientsTransplant immunologyTransplantation ImmunologyTreesUniversity Medical CentersVascular DiseasesVascular DisorderVascular blood supplyWhite Blood CellsWhite CellWorkXenograftXenograft procedureXenotransplantationadvisory teamagesassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbio-markersbiologic markerbiomarkerblood supplyblood vessel disordercardiac allograftcardiac failurecardiac graftcareercareer developmentcausationcell typeclinical careclinical investigationcollaborative approachdetection methoddetection proceduredetection techniquedevelopmentaldisease causationexperiencegene expression patterngene expression signaturegene regulatory networkgraft failureheart allograftheart disorderheart transplanthigh dimensional dataimprovedintracardiac volumeliquid biopsymRNAmRNA Expressionmachine based learningmicrovascular complicationsmicrovascular diseasemodel of animalmolecular phenotypemortalitymultidimensional datamultidimensional datasetsmultiomicsmultiple omicsnew approachesnovel approachesnovel strategiesnovel strategypanomicspatient centeredpatient orientedpatient oriented researchpatient oriented studypost-transplantpost-transplantationposttransplantposttransplantationpreventpreventingprogramsprospectiverecruitsNuc-Seqsample collectionsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqskillssmall vessel diseasesnRNA sequencingsnRNA-seqspecimen collectionstatistical linear mixed modelsstatistical linear modelsstatisticsstudy designsuccesstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttranscriptional profiletranscriptional signaturetranscriptome sequencingtranscriptomic sequencingtranslation researchtranslational investigationtransplant centerstransplant patientvascular dysfunctionvascular supplyvasculopathywhite blood cellwhite blood corpusclexeno-transplantxeno-transplantation
Description preview
PROJECT SUMMARY/ABSTRACT
Cardiac allograft vasculopathy (CAV), a form of chronic rejection, is a leading cause of late graft failure and
mortality after heart transplantation (HT). It is characterized by diffuse intimal thickening of the entire coronary
tree, including the epicardial coronary arteries and microvasculature. Currently, therapies are…
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