grant
Cell signaling through O-linked glycosylation
NIHUS FederalResearch GrantFY2026ASCVDAdaptor ProteinAdaptor Protein GeneAdaptor Signaling ProteinAdaptor Signaling Protein GeneAddressAtherosclerosisAtherosclerotic Cardiovascular DiseaseBinding ProteinsBiochemicalBiological FunctionBiological ProcessBiologyBiophysicsCancersCarbohydratesCell AdhesionCell BodyCell CommunicationCell Communication and SignalingCell FunctionCell InteractionCell LocomotionCell MigrationCell MovementCell PhysiologyCell ProcessCell SignalingCell-to-Cell InteractionCellsCellular AdhesionCellular FunctionCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessCellular biologyChemicalsComplementComplement ProteinsComplexCytoplasmDNA ReplicationDNA SynthesisDNA biosynthesisDefectDevelopmentDiabetes MellitusDiseaseDisorderE3 LigaseE3 Ubiquitin LigaseEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentFoundationsGlycansGlycopeptidesGoalsHumanIntermediate FilamentsIntracellular Communication and SignalingL-SerineL-ThreonineLigand Binding ProteinLigand Binding Protein GeneLinkMalignant NeoplasmsMalignant TumorMammaliaMammalsMediatingMembraneMetabolic GlycosylationMetabolic syndromeModelingModern ManNatureNerve DegenerationNeuron DegenerationNuclearObesityOrganogenesisPathway interactionsPhysiologyPolysaccharidesPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessProtein BindingProtein BiochemistryProtein BiosynthesisProtein GlycosylationProtein ModificationProtein/Amino Acid BiochemistryProteinsQuality ControlRNA biosynthesisReaderRegulationReportingResearchRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisSerineSignal TransductionSignal Transduction SystemsSignalingStructureSubcellular ProcessTechniquesThreonineUbiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3VesicleWorkX-Linked Mental RetardationX-Linked Mental Retardation DisordersX-Linked Mental Retardation SyndromesX-linked intellectual disabilityadapter proteinadiposityatheromatosisatherosclerotic diseaseatherosclerotic vascular diseasebiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencesbound proteincandidate identificationcell biologycell motilitycomplementationcorpulencedevelopmentaldiabetesfluidityglycoproteomicsglycosylationhuman diseaseinsightinterdisciplinary approachinterestmalignancymembrane structuremultidisciplinary approachneoplasm/cancerneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathwayprogramsprotein functionprotein homeostasisprotein protein interactionprotein synthesisproteostasisrespiratorystructural biologysugartraffickingubiquitin-protein ligase
Description preview
Project Summary/Abstract
Glycosylation – the enzymatic attachment of carbohydrates onto biomolecules – is the most abundant
post-translational modification (PTM) of proteins in nature. In mammals, glycosylation influences all aspects of
cell biology, including protein quality control and secretion, intracellular signaling, membrane composition…
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