grant
Cell-lineage specific epigenomic determinants of HIV latency in humanized mouse brain and blood
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 25 Jul 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY202521+ years old3-D3-Dimensional3DAIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAcuteAdultAdult HumanAffectAfter CareAfter-TreatmentAftercareAntimorphic mutationArchitectureAutopsyBindingBiologic ModelsBiological MarkersBiological ModelsBloodBlood Reticuloendothelial SystemBrainBrain InflammationBrain Nervous SystemCNS Nervous SystemCell BodyCell Culture SystemCell Culture TechniquesCell LineageCellsCentral Nervous SystemChromatinChromiumCirculatory CollapseComplexCr elementDiseaseDisorderDominant NegativeDominant-Negative MutantDominant-Negative MutationDrug ModulationDrug TherapyDsRedESETEncephalitisEncephalonEngineering / ArchitectureEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExperimental ModelsFrequenciesGeneticGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGenomeGenome MappingsGenomicsGoalsHIVHIV 1 associated neurocognitive disorderHIV InfectionsHIV associated neurocognitive deficitHIV associated neurocognitive impairmentHIV induced neurocognitive deficitHIV induced neurocognitive impairmentHIV neurocognitive impairmentHIV-1HIV-1 associated neurocognitive deficitHIV-1 associated neurocognitive disorderHIV-1 associated neurocognitive impairmentHIV-IHIV-associated neurocognitive disorderHIV1HTLV-III InfectionsHTLV-III-LAV InfectionsHeterograftHeterologous TransplantationHistone H3HistonesHortega cellHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsHuman immunodeficiency virus 1ImmuneImmune systemImmunesIn VitroInfectionInflammationKG1TKIAA0067KineticsL-LysineLAV-HTLV-IIILife CycleLife Cycle StagesLineage TracingLinkLong Terminal RepeatsLymphadenopathy-Associated VirusLymphatic cellLymphocyteLymphocyticLysineMethionineMethylationMiceMice MammalsMicrogliaModel SystemModern ManMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMurineMusMyelogenousMyeloidMyeloid CellsNerve CellsNerve UnitNeural CellNeuraxisNeurocognitive Impairment in HIVNeurocognitive Impairment in HIV-1NeurocyteNeurologic ManifestationsNeurologic Signs and SymptomsNeurologic SymptomsNeurological ManifestationsNeurological Signs and SymptomsNeuronsOrganPathogenicityPeripheralPersonsPharmacological TreatmentPharmacotherapyPopulationProductivityProvirusesRecombinant DNA TechnologyRegimenReporterRepressionResolutionRetrotransposonRetroviridaeRetrovirusesSETDB1SETDB1 geneShockSiteSortingSpleenSpleen Reticuloendothelial SystemSynapsesSynapticSystemTechniquesTestingTransgenesViralViral DiseasesViral LatencyViral reservoirVirusVirus ActivationVirus DiseasesVirus InductionVirus IntegrationVirus LatencyVirus reservoirVirus-HIVVirus-RetrovirusWorkXenograftXenograft procedureXenotransplantationadulthoodantiretroviral therapyantiretroviral treatmentbio-markersbiologic markerbiomarkerbrain cellcell culturecell culturescell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcell typecellular lineage mappingcellular lineage trackingchromatin remodelingcirculatory shockconformationconformationalconformational stateconformationallyconformationsderepressiondesigndesigningdrug interventiondrug treatmentepigeneticallyepigenomicsgenetic approachgenetic strategygenetically engineeredgitter cellglobal gene expressionglobal transcription profilehiPSChistone H3 methyltransferasehistone methylasehistone methyltransferasehuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellshumanized micehumanized mousein vivoinduced human pluripotent stem cellsinnovateinnovationinnovativeintegration sitelife courselymph cellmesogliamicroglial cellmicrogliocytemouse modelmurine modelnecropsyneural manifestationneuronalnovelnucleic acid long terminal repeatperivascular glial cellpharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspost treatmentpostmortemresolutionsresponsescRNA sequencingscRNA-seqshockssingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsynapsethree dimensionaltissue culturetranscriptometranscriptome profilingtranscriptomic profilingtranscriptomicstransgeneviral activationviral genome integrationviral inductionviral infectionviral integrationvirus genome integrationvirus infectionvirus-induced diseasexeno-transplantxeno-transplantation
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Project Summary
Human immunodeficiency virus type 1 (HIV-1) infection affects more than 38 million people worldwide and
remains incurable due to the early establishment of reservoirs where the virus remains latent. HIV-1 enters the
brain within the first two weeks of infection, and neurologic symptoms have been observed with accompanying
central…
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