grant
Cell lineage and transcriptional analysis of the vertebrate neural plate border
Organization CALIFORNIA INSTITUTE OF TECHNOLOGYLocation PASADENA, UNITED STATESPosted 1 Feb 2018Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026AffectAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBirth DefectsCell BodyCell LineageCellsCephalicCharacteristicsCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationCoupledCouplingCranialDataDefectDevelopmentDorsalDown-RegulationES cellEarEctodermEmbryoEmbryonicEnhancersEquilibriumEventFeedbackGastrulaGene ExpressionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TranscriptionGrantHandHumanImageMaintenanceMediatingModern ManMolecularNerve CellsNerve UnitNeural CellNeural CrestNeural Crest CellNeural Tube ClosureNeural tubeNeurocyteNeuronsOlfactory PathwaysOlfactory systemPeripheral Nervous SystemPlayPopulationProcessProgenitor CellsRNA ExpressionRegulatory ElementReporterRoleSensory GangliaSkeletonSkinSpecific qualifier valueSpecifiedTestingTimeTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesbalancebalance functionc mycc-myc Genescell typecmyccraniofacialcraniofaciesdevelopmentaldrivingembryo derived stem cellembryonal stem cellsembryonic progenitorembryonic stem cellexperimentexperimental researchexperimental studyexperimentsgain of functiongene regulatory networkhandsimagingin vivolenslensesloss of functionmelanocytemultipotencymultipotentneuralneural plateneuronalolfactory circuitryolfactory circuitsoverexpressoverexpressionpluripotencypluripotency factorpluripotent statepreventpreventingprogenitorprogenitor cell nicheprogenitor nichepublic health relevancescATAC sequencingscATAC-seqscRNA sequencingscRNA-seqsingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell sequencing assay for transposase accessible chromatinsingle cell transcriptomic profilingsingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell RNA sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqskeletonssocial rolestem and progenitor cell nichestem cell nichestem cell of embryonic originstem cellstranscription factorv-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog
Description preview
Both neural crest progenitors and ectodermal placode cells arise from the neural plate border (NPB).
While the neural crest gives rise to the craniofacial skeleton, the placodes form the lens, ear and olfactory system;
both contribute to cranial sensory ganglia. However, rather than being fixed to a neural crest or placodal fate,
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