grant

Cell-free DNA to detect transplant rejection

Organization NATIONAL HEART, LUNG, AND BLOOD INSTITUTELocation UNITED STATES
NIHUS FederalResearch GrantFY2025AcuteAddressAdmixtureAlgorithmsAllograftingAntibodiesAreaBiological MarkersBiopsyBloodBlood CellsBlood CirculationBlood PlasmaBlood Reticuloendothelial SystemBloodstreamCOVID-19CV-19Cardiac TransplantationCell BodyCellsCessation of lifeCharacteristicsChronicCirculationClinicalClinical DataClinical ResearchClinical StudyCohort StudiesCollectionComplementComplement ProteinsConcurrent StudiesCoronavirus Infectious Disease 2019DNADNA SequenceDeathDedicationsDeoxyribonucleic AcidDrug TargetingDysfunctionEnsureEnvironmentExhibitsFDA approvedFaceFunctional disorderGenerationsGenomicsGraft RejectionGrafting ProcedureHeart GraftingHeart TransplantationHospitalsImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsInfectionInjuryLaboratoriesLifeLiquid substanceLung DiseasesLung GraftingLung TransplantationMediatingMediatorMolecularMonitorNHLBINational Heart, Lung, and Blood InstituteNatural HistoryOrganOrgan TransplantationOrgan TransplantsOutcomePTK InhibitorsPathway interactionsPatient MonitoringPatient RecruitmentsPatientsPeripheral Blood CellPhagocytesPhagocytic CellPhysiopathologyPlacebosPlasmaPlasma SerumPrincipal InvestigatorProcessProtein Tyrosine Kinase InhibitorsPublishingPulmonary DiseasesPulmonary DisorderPulmonary GraftPulmonary TransplantPulmonary TransplantationRandomized, Controlled TrialsResearchResearch InfrastructureReticuloendothelial System, Serum, PlasmaRiskSYKSYK geneSafetySamplingSeriesSham TreatmentSiteSolidSpleen Tyrosine KinaseTK InhibitorsTechniquesTestingTransplant RecipientsTransplant RejectionTransplantationTransplantation RejectionTreatment FailureTyrosine Kinase InhibitorTyrosine-Protein Kinase SYKWaiting ListsWashingtonallograft rejectionamebocyteantibody rejectionantibody-mediated rejectionbio-markersbiobankbiologic markerbiomarkerbiorepositorycardiac graftcell free DNAcell free DNA profilingcell free DNA screeningcell free DNA-based assaycell free circulating DNAcell-free DNA assaycell-free DNA testcfDNA assaycfDNA profilingcfDNA screeningcfDNA testcfDNA-based assaycomplementationcoronavirus disease 2019coronavirus disease-19coronavirus infectious disease-19diagnostic tooldisease of the lungdisorder of the lungdisparities in racedisparity due to raceefficacy testingfacesfacialfluidheart transplantimprovedimproved outcomeinequality due to raceinequity due to raceinhibitorinjuriesliquidlung allograftlung disorderlung transplantmetropolitanmortalitymultiomicsmultiple omicsnew diagnosticsnext generation diagnosticsnovelnovel diagnosticsorgan allograftorgan graftorgan xenograftpanomicsparticipant recruitmentpathophysiologypathwaypatient populationpatient stratificationpost-transplantpost-transplantationposttransplantposttransplantationpreventpreventingpulmonary arterial hypertensionpulmonary artery hypertensionrace based disparityrace based inequalityrace based inequityrace disparityrace related disparityrace related inequalityrace related inequityracial disparityracial inequalityracial inequityracially unequalrandomized control trialremote monitoringsham therapystratified patienttargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttest using cell free DNAtests using cfDNAtherapy failuretransplanttransplant centerstransplant patientwaitlist
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**Project 1: Cell-free DNA for Detecting Acute Rejection**
Dr. Agbor led the creation of the Genomic Research Alliance for Transplantation (GRAfT), a consortium comprising five transplant centers in the Washington, DC metropolitan area and the National Heart, Lung, and Blood Institute (NHLBI). He serves as the principal investigator for a…

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Cell-free DNA to detect transplant rejection — NATIONAL HEART, LUNG, AND BLOOD INSTITUTE | UNITED STATES | Dev Procure