grant
Cell Competition in Development and Homeostasis
Organization UNIVERSITY OF CALIFORNIA-IRVINELocation IRVINE, UNITED STATESPosted 15 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AT HooksAT-Hook MotifsATHAberrant ChromosomeAbnormal CellAbscissionAffectAgingAneuploidAneuploid CellsAneuploidyAntioncogene Protein p53AssayAutoregulationBasal Transcription FactorBasal transcription factor genesBioassayBiogenesisBiologic ModelsBiological AssayBiological ModelsBody TissuesCancer InductionCancersCell AgingCell BodyCell CommunicationCell Communication and SignalingCell FunctionCell InteractionCell NucleusCell PhysiologyCell ProcessCell SenescenceCell SignalingCell-to-Cell InteractionCellsCellular AgingCellular FunctionCellular PhysiologyCellular ProcessCellular SenescenceCellular Tumor Antigen P53Cellular injuryChromosomal AberrationsChromosomal AbnormalitiesChromosomal AlterationsChromosome AberrationsChromosome AlterationsChromosome AnomaliesChromosome MappingChromosome abnormalityChromosomesCytogenetic AberrationsCytogenetic AbnormalitiesDNA DamageDNA InjuryDNA Transposable ElementsDNA mutationDeteriorationDevelopmentDrosophilaDrosophila genusExcisionExtirpationFrequenciesGene ExpressionGene LocalizationGene MappingGene Mapping GeneticsGene ProteinsGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic ChangeGenetic ModelsGenetic defectGenetic mutationGenomeGenomicsGenotypeHeterozygoteHomeostasisHumanHyperplasiaHyperplasticIncidenceIntracellular Communication and SignalingLabelLeadLinkage MappingMalignant CellMalignant NeoplasmsMalignant TumorMammaliaMammalsMeasuresMiceMice MammalsModel SystemModern ManMolecularMonosomyMurineMusMutationNormal CellNormal TissueNormal tissue morphologyNucleusOncogenesisOncoprotein p53Origin of LifeP53Pathway interactionsPb elementPhenotypePhosphoprotein P53Phosphoprotein pp53Physiological HomeostasisProcessProtein Gene ProductsProtein TP53RemovalReplicative SenescenceRibosomal ProteinsRibosomesRoleRouteSignal TransductionSignal Transduction SystemsSignalingSubcellular ProcessSurgical RemovalTP53TP53 geneTRP53TimeTissuesTotal Human and Non-Human Gene MappingTranscription Factor Proto-OncogeneTranscription factor genesTransposable ElementsTumor PromotionTumor Protein p53Tumor Protein p53 GeneYeastsbiological signal transductioncancer cellcarcinogenesiscell damagecell injurycell typecellular damagechromosomal defectchromosome defectchromosome number abnormalitydamage to cellsdevelopmentalfruit flygain of functiongenetic mappinggenome integritygenome mutationgenomic integrityhallmarks of aginghealthy aginghealthy human agingheavy metal Pbheavy metal leadheterozygosityin vivoinjury to cellsinsightirradiationknock-downknockdownloss of functionmalignancymosaicmutantneoplasm/canceroverexpressoverexpressionp53 Antigenp53 Genesp53 Tumor Suppressorpathwaypillars of agingpreventpreventingpro-agingprogeronicpromote agingprotein p53replicative agingresectionresponsesensorsocial roletranscription factortranscriptome profilingtranscriptomic profilingtumortumorigenesistumorigenic
Description preview
A process of cell competition can remove cells that differ genetically from neighboring
cells in the same tissues. Cell competition helps to eliminate sporadic aneuploid cells
that have abnormal chromosome numbers. Aneuploidy contributes to almost all
carcinogenesis and is a hallmark of aging, contributing to cellular senescence. The
current…
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