grant
Cell-based therapies for retinal degeneration
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 1 Jun 2024Deadline 31 May 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAccountingAddressAffectAge related macular degenerationAge-Related MaculopathyAmacrine CellsAtrophicAtrophic AMDAtrophic age-related macular degenerationAtrophyAutomobile DrivingBlindnessCell BodyCell TherapyCell TransplantationCellsCommunicationConeDegenerative DisorderDetectionDeveloped CountriesDry AMDDrynessEvaluationEventGoalsIndustrialized CountriesIndustrialized NationsLeadLightMiniature SwineMinipigsModelingNatural regenerationNerve CellsNerve UnitNeural CellNeurocyteNeuronsNon-exudative age-related macular degenerationNonexudative age-related macular degenerationOperative ProceduresOperative Surgical ProceduresOutcomeOuter pigmented layer of retinaPatientsPb elementPhotoradiationPhotoreceptor CellPhotoreceptorsPhotosensitive CellPhysiologicPhysiologicalPigment cell layer of retinaPigmented layer of retinaProgenitor Cell TransplantationProgenitor CellsRegenerationResolutionRetinaRetinal DegenerationRetinal Pigment EpitheliumRetinal pigment epithelial cellsRodSightStem Cell TransplantationStem cell transplantStructure of retinal pigment epitheliumSurgicalSurgical InterventionsSurgical ProcedureSynapsesSynapticTechnologyTestingTissue TransplantationTransplantationVisionVisual Receptorage dependent macular degenerationage induced macular degenerationage related macular diseaseage related macular dystrophycell based interventioncell mediated interventioncell mediated therapiescell replacement therapycell replacement treatmentcell typecell-based therapeuticcell-based therapycellular therapeuticcellular therapycellular transplantdegenerative conditiondegenerative diseasedegenerative retina diseasesdesigndesigningdeveloped countrydeveloped nationdeveloped nationsdrivingdry age-related macular degenerationgangliocyteganglion cellheavy metal Pbheavy metal leadhiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsimplantationin vivoinduced human pluripotent stem cellsinnovateinnovationinnovativelight transmissionmaculamacularmini pigmini-swineminiswinemulti-modalitymultimodalityneuronalnovelpost-transplantpost-transplantationposttransplantposttransplantationpre-clinicalpreclinicalprogenitor transplantationregenerateregeneration based therapyregeneration therapyregenerative therapeuticsregenerative therapyresolutionsresponserestore sightrestore visionretina degenerationretina transplantationretinal degenerativeretinal degenerative diseasesretinal regenerationretinal transplantationsenile macular diseasesight restorationstandard of carestem and progenitor cell transplantationsstem cellssurgerysynapsethree dimensionaltransplantvision lossvision restorationvisual functionvisual loss
Description preview
PROJECT SUMMARY/ABSTRACT
This project addresses the NEI Audacious Goal Initiative (AGI) of restoring vision through regeneration of
photoreceptor cells and their connections. Among degenerative diseases of the outer retina amenable to
regenerative therapies, dry age-related macular degeneration (AMD) is a major target. AMD is the leading
cause of…
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