grant
CD45 mediated regulation of PMN function during intestinal inflammation
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 1 Sept 2025Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025AbscessAntibodiesApoptosisApoptosis PathwayB220BindingBinding ProteinsBlood NeutrophilBlood Polymorphonuclear NeutrophilBody TissuesCAGACD11bCD18CD45CGLACR3ACell BodyCell Communication and SignalingCell SignalingCellsChronicClinicalClosure by LigationColitisColon InjuryComplexCytosolic Protein Tyrosine PhosphastaseDataDiseaseDisorderDropsyEdemaEpitheliumEventGP180GlycansGoalsGoblet CellsHost DefenseHumanHydropsHyperplasiaHyperplasticITGAMITGAM geneITGB2ITGB2 geneIn VitroIndividualInfiltrationInflammationInflammatoryInflammatory Bowel DiseasesInflammatory Bowel DisorderInflammatory ResponseInjuryIntegrinsIntegrins Extracellular MatrixIntestinalIntestinesIntracellular Communication and SignalingIsoformsKO miceKinasesKnock-outKnock-out MiceKnockoutKnockout MiceLCAMBLY5LectinLigand Binding ProteinLigand Binding Protein GeneLigandsLigationLinkMA387MAC1AMF17MO1AMRP8Marrow NeutrophilMediatingMetabolic GlycosylationMiceMice MammalsModern ManMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMucosaMucosal InflammationMucosal TissueMucositisMucous MembraneMucous body substanceMucusMurineMusNeutrophil ActivationNeutrophilic GranulocyteNeutrophilic LeukocyteNull MousePTP Family GenePTPRCPTPRC genePTPasePathogenesisPathologicPathologyPhagocytosisPhosphatasesPhosphohydrolasesPhosphomonoesterasesPhosphoric Monoester HydrolasesPhosphotransferase GenePhosphotransferasesPhosphotyrosine PhosphatasePhosphotyrosyl Protein PhosphatasePlayPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPolysaccharidesProductionProgrammed Cell DeathProtein BindingProtein IsoformsProtein Tyrosine PhosphataseProtein Tyrosine Phosphatase GeneProteinsQOL improvementRNA SplicingReceptor Type PTP GeneRegulationRoleS100A8S100A8 geneSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSplicingStructureSuperoxide AnionSuperoxide RadicalSuperoxidesT200TissuesTransphosphorylasesTyrosine PhosphataseTyrosyl Phosphoprotein PhosphataseUlcerUlcerationVariantVariationbiological signal transductionbound proteinbowelbowel inflammationconformationconformationalconformational stateconformationallyconformationscrypt cellextracellularfunctional outcomesglycosylationgut inflammationimprovedimprovements in QOLimprovements in quality of lifein vivoinflamed bowelinflamed gutinflamed intestineinflammatory disease of the intestineinflammatory disorder of the intestineinjuriesinjury and repairintestinal autoinflammationintestinal epitheliumintestinal inflammationmigrationmucousneutrophilnew approachesnovelnovel approachesnovel strategiesnovel strategyprotein tyrosine phosphate phosphohydrolasequality of life improvementrepairrepairedsocial rolesrc Kinasessrc Protein-Tyrosine Kinasessrc Tyrosine Kinasessrc-Family Kinasessrc-Family Tyrosine Kinasestargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttissue repairtrafficking
Description preview
Abstract:
It has been well documented that disease activity in inflammatory mucosal diseases including inflammatory
bowel disease is linked to the transepithelial migration of neutrophils through the mucosal epithelium and
ultimately into the intestinal lumen. Co-incident with massive luminal influx of neutrophils is uncontrolled release
of toxic…
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