grant

CD37 as a Regulator of Platelet Patho(Physiological) Responses

Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 15 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025ASCVDAccelerationActive Follow-upAffectAffinity ChromatographyAffinity Labeling ReagentsAffinity LabelsAgonistApoplexyAreaArteriesAtherogenicityAtherosclerosisAtherosclerotic Cardiovascular DiseaseB-Cell Differentiation Factor GeneB-Cell Stimulatory Factor 2 GeneBSF-2 GeneBSF2 GeneBeta-2 Gene InterferonBindingBinding ProteinsBiological Response ModifiersBiomodulatorsBleedingBlood PlateletsBlood leukocyteBlood monocyteBone MarrowBone Marrow Reticuloendothelial SystemBrain Vascular AccidentCITE sequencingCITE-seqCITEseqCVD preventionCardiac infarctionCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell Membrane Lipid RaftsCell SignalingCell-to-Cell InteractionCellsCellular Indexing of Transcriptomes and Epitopes by SequencingCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCessation of lifeChronicClinicalCytometryDataDeathDevelopmentDiseaseDisorderEventFoundationsGenesHSF GeneHeart VascularHemorrhageHemostasisHemostatic AgentsHemostatic functionHemostaticsHepatocyte Stimulatory Factor GeneHumanHybridoma Growth Factor GeneIFNB2 GeneIL-6 GeneIL6IL6 geneImmune MediatorsImmune Mediators/ModulatorsIndividualInflammationInflammatoryInnate Immune ResponseIntegrinsIntegrins Extracellular MatrixInterleukin 6 (Interferon, Beta 2) GeneInterleukin-6 GeneIntracellular Communication and SignalingKO miceKnock-out MiceKnockout MiceKnowledgeLeukocytesLeukocytes Reticuloendothelial SystemLigand Binding ProteinLigand Binding Protein GeneMacrophageMarrow leukocyteMarrow monocyteMarrow plateletMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMediatorMembrane MicrodomainsMesentericMesenteryMiceMice MammalsMicroscopyModelingModern ManMolecularMolecular InteractionMurineMusMyocardial InfarctMyocardial InfarctionNull MouseOutcomePathogenesisPathological ConstrictionPathway interactionsPatientsPatternPhenocopyPhenotypePhysiologicPhysiologicalPlaque InstabilityPlatelet ActivationPlatelet aggregationPlateletsPlayPrimary PreventionProtein BindingProtein Binding DomainProtein Binding MotifProtein-Protein Interaction DomainProteinsRNA SeqRNA sequencingRNAseqReceptor ProteinResolutionRestRiskRoleSignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSphingolipid MicrodomainsSphingolipid-Cholesterol RaftsStenosisStrokeTestingTherapeuticThrombocytesThrombosisThrombusTimeTransplantationWhite Blood CellsWhite Cellactive followupadaptive immunityaffinity labelingaffinity purificationarterioleatherogenesisatheromatosisatherosclerotic diseaseatherosclerotic vascular diseaseatherothrombosisbiological signal transductionblood lossbound proteinbrain attackcardiac disease preventioncardiac infarctcardioprotectantcardioprotectioncardioprotectivecardiovascular disease preventioncardiovascular disordercardiovascular disorder preventioncellular indexing of transcriptomes and epitopes by single cell sequencingcerebral vascular accidentcerebrovascular accidentcirculatory systemcohortcoronary attackcoronary infarctcoronary infarctiondevelopmentalfollow upfollow-upfollowed upfollowupheart attackheart infarctheart infarctionin vivoindexinginjury to the vasculatureinsightlipid raftmonocytemouse modelmurine modelnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetpathwayplaque vulnerabilitypreventpreventingreceptorrecruitresolutionsresponseshear stresssocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstrokedstrokessystemic inflammationsystemic inflammatory responsethrombotic diseasethrombotic disordertranscriptome sequencingtranscriptomic sequencingtransplantunstable plaquevascular injurywhite blood cellwhite blood corpuscle
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Description preview

SUMMARY
Eighty-five percent (85%) of cardiovascular disease deaths occur due to either myocardial infarction (MI) or

stroke, platelet-driven events. While antiplatelet therapy for secondary CVD prevention is well-established,

antiplatelet therapy is not commonly prescribed to prevent a first MI or stroke as the cardioprotective benefits

are offset…

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CD37 as a Regulator of Platelet Patho(Physiological) Responses — NEW YORK UNIVERSITY SCHOOL OF MEDICINE | UNITED STATES | Dev Procure