grant
CD103 engagement regulates intestinal IEL effector function
Organization RUTGERS BIOMEDICAL AND HEALTH SCIENCESLocation Newark, UNITED STATESPosted 10 Feb 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026AddressAntigensAutoimmune StatusAutoimmunityAutoregulationBehaviorBindingBiological FunctionBiological ProcessBlast TransformationBlastogenesisBody TissuesCD8CD8BCD8B1CD8B1 geneCadherin-1CarcinomaCeliac DiseaseCeliac SprueCell BodyCell Communication and SignalingCell FunctionCell LineCell PhysiologyCell ProcessCell SignalingCellLineCellsCellular FunctionCellular PhysiologyCellular ProcessClosure by LigationCoeliac DiseaseColon or RectumColorectalCommunicable DiseasesCuesCytoplasmic GranulesE-CadherinEpithelial Calcium-Dependent Adhesion ProteinEpithelial CellsEpithelial cancerEpithelial-CadherinEpitheliumEventExhibitsExocytosisGene ExpressionGluten EnteropathyGluten-Sensitive EnteropathyGoalsGranzymeHomeostasisImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune systemImmunityImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionInfectionInfection ControlInfectious DiseasesInfectious DisorderInflammatory Bowel DiseasesInflammatory Bowel DisorderIntegrinsIntegrins Extracellular MatrixIntestinalIntestinesIntracellular Communication and SignalingInvadedInvestigationKnowledgeLYT3LigationLymphatic cellLymphoblast TransformationLymphocyteLymphocyte ActivationLymphocyte CountLymphocyte FunctionLymphocyte NumberLymphocyte StimulationLymphocyte TransformationLymphocyticMaintenanceMalignant Epithelial NeoplasmsMalignant Epithelial TumorsMediatingMemoryMicrobeMissionModelingMolecularMolecular InteractionMotilityMucosaMucosal TissueMucous MembraneNIAIDNational Institute of Allergy and Infectious DiseaseNational Institutes of HealthNontropical SpruePathogenicityPhysiological HomeostasisPlayPopulationPublic HealthRegulationResearchRestRoleSentinelSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteStrains Cell LinesSubcellular ProcessT-CellsT-LymphocyteTherapeuticTissuesTotal Lymphocyte CountToxinTumor-Infiltrating LymphocytesUnited States National Institutes of HealthUvomorulinViral DiseasesVirus DiseasesWorkbiological signal transductionbowelcadherin 10colorectumcombinatorialcultured cell linecytokinedietaryenteral infectionenteral pathogenenteric infectionenteric pathogenenteric pathogen infectionenteropathogenenteropathogen infectionenteropathogenic infectionepithelial carcinomaexperimentexperimental researchexperimental studyexperimentsgastrointestinal homeostasisgranulehuman diseaseidiopathic steatorrheaimmunogenimproved outcomein vivoinfected with enteropathogeninflammatory disease of the intestineinflammatory disorder of the intestineinsightintestinal autoinflammationintestinal barrierintestinal epitheliumintestinal homeostasisintestinal infectionintestinal mucosal barrierintestinal pathogenintestine infectionintestine pathogenintraepitheliallymph cellmicrobialmicroorganismmigrationnovelpathogenpreventpreventingrecruitresponsesocial rolethymus derived lymphocyteviral infectionvirus infectionvirus-induced disease
Description preview
PROJECT SUMMARY.
Mucosal surveillance of the intestinal barrier by tissue-resident lymphocytes is critical for preventing the
invasion of enteric pathogens and a necessary component of protective immunity. A single layer of epithelial
cells lines the intestinal tract and provides a physical barrier between microbes, dietary antigens, toxins and…
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