grant
CB1-mediated signaling in developmental ethanol effects
Organization NATHAN S. KLINE INSTITUTE FOR PSYCH RESLocation ORANGEBURG, UNITED STATESPosted 18 Sept 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY202521+ years old3rd trimesterAdultAdult ChildrenAdult DaughtersAdult HumanAdult OffspringAdult SonsAffectAffinity ChromatographyAlcohol Chemical ClassAlcoholsAmmon HornAnimalsAntigenic DeterminantsAttentionBasal Transcription FactorBasal transcription factor genesBehavioralBinding DeterminantsBrainBrain Nervous SystemBreedingCB1CB1 ReceptorCB1 knock outCB1 knockoutCB1 nullCB1-/-CB1RCB1R knock outCB1R knockoutCNR1 geneCannabinoid Receptor CB1Cell Communication and SignalingCell SignalingCognitiveCornu AmmonisCounselingDataDefectDevelopmentDysfunctionElectron MicroscopyEncephalonEnhancersEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpitopesEventFASDFemaleFetal Alcohol Spectrum DisorderFore-BrainForebrainFunctional disorderGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TranscriptionGestationGlutamatesGoalsGolgiGolgi ApparatusGolgi ComplexHealth Care ProfessionalHealth ProfessionalHemagglutininHippocampusHistonesHumanImmune PrecipitationImmunoprecipitationImpairmentIndividualIntracellular Communication and SignalingKnowledgeL-GlutamateL-LysineLaboratoriesLast TrimesterLearningLifeLong-Term PotentiationLoxP-flanked alleleLysineMediatingMemoryMemory DeficitMemory impairmentMessenger RNAMethodsMethylationMiceMice MammalsModelingModern ManMolecularMurineMusNerve CellsNerve DegenerationNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeurocyteNeurodevelopmental DisabilityNeurodevelopmental DisorderNeurologic DisordersNeurological Development DisorderNeurological DisordersNeuron DegenerationNeuronsPathway interactionsPhysiopathologyPolyribosomesPolysomesPrefrontal CortexPregnancyPreventative strategyPrevention strategyPreventive strategyProsencephalonProteinsPsychopathologyRNA ExpressionRegulationReportingResearchRibo-seqRiboTagRibosomal ProteinsRibosomesRoleSignal TransductionSignal Transduction SystemsSignalingSocial BehaviorSpinal ColumnSpineStaining methodStainsStructureSynapsesSynapticSynaptic VesiclesSynaptic plasticityTamoxifenTechnologyTeratogenic effectsTestingTherapeutic InterventionThird Pregnancy TrimesterThird TrimesterTranscriptTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTranslatingTranslationsVertebral columnWomanabnormal psychologyadulthoodaffinity purificationalcohol abuse during pregnancyalcohol abuse in pregnancyalcohol effectalcohol exposedalcohol exposurebackbonebehavior outcomebehavioral impairmentbehavioral outcomebinge alcohol consumptionbinge drinkingbiological signal transductioncannabinoid receptorcannabinoid receptor 1cannabinoid receptor type 1cannabinoid type 1cell typecompare to controlcomparison controlconditional knock-outconditional knockoutdevelopmentaleffective therapyeffective treatmentepigeneticallyepisodic drinkingethanol effectethanol exposedethanol exposureexposed to alcoholexposed to ethanolexposure to alcoholexposure to ethanolfetalfloxedfloxed alleleglutamatergichippocampalhistone methylationimpaired behaviorin vivointervention therapymRNAmalematernal alcohol consumptionmaternal alcohol drinkingmaternal alcohol ingestionmaternal alcohol usematernal ethanol usememory dysfunctionmemory recognitionmouse modelmurine modelneonatal miceneural degenerationneurobehavioralneurodegenerationneurodegenerativeneurodevelopmental diseaseneurological degenerationneurological diseaseneuronalneuronal degenerationnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnon-geneticnongeneticnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetoffspringpathophysiologypathwaypostnatalpuprecombinaseresponseribosome footprint profilingribosome profilingsexsocialsocial rolesociobehaviorsociobehavioralsynapsesynapse functionsynaptic functiontherapeutic targettranscription factortranslationtranslatomevapor♀♂
Description preview
Project Summary
During pregnancy, alcohol abuse produces persistent changes in the fetal brain, causing behavioral
impairments throughout life. These conditions are defined as fetal alcohol spectrum disorder (FASD). Most
concerningly, regular binge drinking during pregnancy causes cognitive and socio-behavioral deficits in offspring.
However, the…
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