grant
Causal mechanisms of expectation bias in frontal cortex and its role in motivated behaviors
Organization NEW YORK UNIVERSITYLocation NEW YORK, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2026AffectiveAnimalsAnteriorAttenuatedBasic ResearchBasic ScienceBehaviorBehavioralBehavioral ParadigmBrainBrain Nervous SystemCell Communication and SignalingCell SignalingCentral LobeClinicalCognitiveComplexDataDetectionDevelopmentDiseaseDisease ResistanceDisorderE-stimElectric StimulationElectrodesEmotionalEncephalonEnvironmentEvaluationEventFutureGamblingGenerationsGustationHumanIndividualInsulaInsula of ReilInterventionIntracellular Communication and SignalingInvestigationIsland of ReilLifeLinkMacacaMacaqueMajor Depressive DisorderMapsMedicineMental DepressionMetabolicModern ManMonkeysMoodsNatureNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurosciencesOutcomePanicPanic DisorderPathologicPatientsPatternPlacebo EffectPopulationPositionPositioning AttributePrimatesPrimates MammalsProcessPsychiatryReference RangesReference ValuesResearchResearch ResourcesResistanceResourcesRewardsRisk BehaviorsRisky BehaviorRoleSignal TransductionSignal Transduction SystemsSignalingSocial Anxiety DisorderSpecificityStimulusSubstance Use DisorderSystemTasteTaste PerceptionTechniquesTestingTherapeuticUpdateWorkat risk behaviorattenuateattenuatesbehavior influencebehavior responsebehavioral influencebehavioral responsebiological signal transductionbipolar maniacareercingulate cortexclinical depressionclinical translationclinically translatablecomputer based predictioncontinuous monitoringdensitydepressiondevelopmentaldrug rewardelectrical microstimulationelectrostimulationemotion dysregulationemotional dysregulationexpectancy effectexpectationexpectation effectfrontal cortexfrontal lobegeneralized anxietygustatory perceptiongustatory processinggustatory responseinnovateinnovationinnovativemajor depressionmajor depression disordermicrostimulationmotivated behaviorneuralneural circuitneural circuitryneural controlneural mechanismneural networkneural regulationneural stimulationneurocircuitryneuromechanismneuromodulationneuromodulatoryneuronalneurophysiologicalneurophysiologyneuropsychiatricneuropsychiatric diseaseneuropsychiatric disorderneuropsychiatryneuroregulationnext generationnocebonon-human primatenonhuman primatenoveloptimismpanic anxiety syndromeplacebo responsepositive attitudepredictive modelingresistance to diseaseresistantresistant diseaseresistant to diseaseresponseskillssocialsocial anxietysocial rolesocially anxioussubstance use and disordersynaptic circuitsynaptic circuitrytaste processingtaste responsetraining opportunitytraining project
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Project Summary
Neuropsychiatric disorders frequently fail to respond to first-line treatments, highlighting the urgent need for
innovative therapeutic approaches targeting underlying neural mechanisms. A common feature across
neuropsychiatric disorders is pathological expectation states, including both pathologically negative expectations
(e.g.,…
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