grant
Caspr/11-dependent immunothrombosis and neuroinflammation during SARS-CoV-2 infection
Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 10 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoVAcuteAlimentary CanalAntithrombin VIBlood - brain barrier anatomyBlood CellsBlood CirculationBlood Coagulation DisordersBlood Coagulation Factor IIIBlood SampleBlood VesselsBlood specimenBlood-Brain BarrierBloodstreamBody TissuesBody Weight decreasedBrainBrain Nervous SystemBrain PathologyCASP11CASP4CASP4 geneCD142 AntigensCOVID crisisCOVID epidemicCOVID infected patientCOVID pandemicCOVID patientCOVID positive patientCOVID-19COVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 infected patientCOVID-19 infectionCOVID-19 pandemicCOVID-19 patientCOVID-19 periodCOVID-19 positive patientCOVID-19 public health crisisCOVID-19 virusCOVID-19 virus infectionCOVID-19 yearsCOVID19 infectionCOVID19 patientCOVID19 positive patientCOVID19 virusCV-19CaspaseCaspase GeneCell BodyCell DeathCell FunctionCell LocomotionCell MigrationCell Migration PathwayCell MovementCell PhysiologyCell ProcessCell-Death ProteaseCellsCellular FunctionCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessCephalalgiaCephalgiaCephalodyniaCerebrumCessation of lifeCoV-2CoV2Coagulation DisorderCoagulation Factor IIICoagulinCoagulopathyCodeCoding SystemCollaborationsComplementComplement ProteinsCoronavirus Infectious Disease 2019Cranial PainCysteine EndopeptidasesCysteine ProteaseCysteine ProteinasesD-dimerD-dimer fibrinD-dimer fragmentsDataDeathDevelopmentDigestive TractDiseaseDisorderEncephalonEndothelial CellsFactor IIIFibrin Degradation ProductsFibrin Fibrinogen Degradation ProductsFibrin Fibrinogen Split ProductsFibrin fragment DFibrin split productsGI TractGastrointestinal TractGastrointestinal tract structureGene ExpressionGenesGliaGlial CellsGlomerular Procoagulant ActivityGoalsHead PainHeadacheHealthHemato-Encephalic BarrierHumanICE and CED3 Homolog 2ICE-like proteaseICH-2ImmuneImmunesIndividualInfectionInflammasomeInflammationInnate Immune SystemKO miceKnock-out MiceKnockout MiceKolliker's reticulumLiverLong COVIDLong COVID-19Long coronavirus diseaseLong coronavirus disease 2019LungLung InflammationLung Respiratory SystemLung infectionsLymphatic cellLymphocyteLymphocyticMediatingMiceMice MammalsModern ManMouse Homolog of Caspase 11MurineMusMyelinNerve CellsNerve UnitNeural CellNeurocyteNeurogliaNeuroglial CellsNeuronsNon-Polyadenylated RNANon-neuronal cellNonneuronal cellNull MousePathogenicityPathologyPathway interactionsPatientsPeripheral Blood CellPersonsPhasePneumonitisProductionProthrombinasePulmonary InflammationRNARNA Gene ProductsRNA SeqRNA sequencingRNAseqResolutionRibonucleic AcidRistocetin CofactorRistocetin-Willebrand FactorRoleRole of PI3K subunit p85 in regulation of Actin Organization and Cell MigrationSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 infected patientSARS-CoV-2 infectionSARS-CoV-2 pandemicSARS-CoV-2 patientSARS-CoV-2 positive patientSARS-CoV2SARS-CoV2 infectionSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SepsisSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 pandemicSevere acute respiratory syndrome related corona virus 2Severity of illnessSubcellular ProcessSurvivorsSymptomsSynapsesSynapticT cell responseTestingThromboplastinThrombosisThrombusTissue FactorTissue Factor ProcoagulantTissue ThromboplastinTissuesUrothromboplastinViral BurdenViral LoadViral Load resultVirusWeight LossWeight ReductionWild Type MouseWuhan coronavirusadaptive immunityalimentary tractbleeding disorderbloodbrain barrierbody weight lossbrain fogcell motilitycell typecerebralchronic COVIDchronic COVID-19chronic novel coronavirus disease 2019clotting disordercomplementationcoronavirus disease 2019coronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 infected patientcoronavirus disease 2019 infectioncoronavirus disease 2019 pandemiccoronavirus disease 2019 patientcoronavirus disease 2019 positive patientcoronavirus disease 2019 public health crisiscoronavirus disease 2019 viruscoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease infected patientcoronavirus disease pandemiccoronavirus disease patientcoronavirus disease positive patientcoronavirus disease-19coronavirus disease-19 global pandemiccoronavirus disease-19 pandemiccoronavirus disease-19 patientcoronavirus disease-19 viruscoronavirus infectious disease-19coronavirus patientcystein proteasecystein proteinasecysteine endopeptidasecytokinecytokine release syndromecytokine stormdesigndesigningdevelopmentaldigestive canaldisease severityfibrin fragment D-dimerfibrin fragment D1 dimerfibrin fragment DDhCoV19head achehepatic body systemhepatic organ systemimmune cell-mediated thrombosisimmune-mediated thrombosisimmunothrombosisimmunothromboticimprovedinfected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with severe acute respiratory syndrome coronavirus 2inhibitorlife-threatening COVIDlife-threatening COVID-19life-threatening SARS-CoV-2life-threatening coronavirus diseaselife-threatening coronavirus disease 2019life-threatening severe acute respiratory syndrome coronavirus 2long haul COVIDlong haul COVID-19long haul coronavirus diseaselong haul coronavirus disease 2019long-hauler COVIDlong-hauler COVID-19long-hauler coronavirus disease 2019long-hauler syndromelong-term COVIDlong-term COVID-19long-term coronavirus diseaselong-term coronavirus disease 2019lymph cellmembernCoV2nasal swabnecrocytosisnerve cementneural inflammationneuroinflammationneuroinflammatoryneuronalnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathwaypatient infected with COVIDpatient infected with COVID-19patient infected with SARS-CoV-2patient infected with coronavirus diseasepatient infected with coronavirus disease 2019patient infected with severe acute respiratory syndrome coronavirus 2patient with COVIDpatient with COVID-19patient with COVID19patient with SARS-CoV-2patient with coronavirus diseasepatient with coronavirus disease 2019patient with severe acute respiratory distress syndrome coronavirus 2persistent COVID-19post COVID syndromepost COVID-19 syndromepost acute COVID syndromepost acute COVID-19post acute COVID-19 syndromepost acute SARS-CoV-2post acute coronavirus disease 2019post acute coronavirus disease 2019 syndromepost acute coronavirus disease syndromepost acute severe acute respiratory syndrome coronavirus 2post coronavirus disease 2019 syndromepost coronavirus disease syndromepost-acute phases of COVID-19preventpreventingprogramsprolonged COVID-19 symptomspulmonarypulmonary infectionsresolutionsresponsescRNA sequencingscRNA-seqserious COVIDserious COVID-19serious SARS-CoV-2serious coronavirus diseaseserious coronavirus disease 2019serious severe acute respiratory syndrome coronavirus 2severe COVIDsevere COVID-19severe COVID19severe SARS-CoV-2severe acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicsevere acute respiratory syndrome coronavirus 2 infected patientsevere acute respiratory syndrome coronavirus 2 patientsevere acute respiratory syndrome coronavirus 2 positive patientsevere coronavirus diseasesevere coronavirus disease 19severe coronavirus disease 2019severe severe acute respiratory syndrome coronavirus 2single cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesynapsesynergismtherapeutic targetthrombotic diseasethrombotic disordertranscriptome sequencingtranscriptomic sequencingtranscriptomicsvascularvon Willebrand Factorvon Willebrand Proteinwildtype mousewt-loss
Description preview
PROJECT 2 - SUMMARY
COVID-19 is caused by pulmonary infection with SARS-CoV-2 virus and has become a world-
wide health problem. More than 6 million people passed away and among the survivors, 33%
complain from symptoms that do not disappear after the acute phase of infection which is called
Long-COVID. Notably, during infection, patients with…
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