grant
CARMIL1 and Endothelial Barrier Function Regulation
Organization UNIVERSITY OF ILLINOIS AT CHICAGOLocation Chicago, UNITED STATESPosted 1 Sept 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025ARDSActin FilamentsActinsAcute Lung InjuryAcute Pulmonary InjuryAcute Respiratory DistressAcute Respiratory Distress SyndromeAdult ARDSAdult RDSAdult Respiratory Distress SyndromeAirAirway failureAlveolarAmino AcidsAreaAssayBindingBioassayBiochemicalBiological AssayBlood Plasma CellBlood VesselsBlood capillariesBreathing MechanicsCTTNCTTN GeneCaringCell BodyCell FractionationCell LineCell LocomotionCell Membrane ExtensionsCell Membrane ProjectionsCell Membrane ProtrusionsCell MigrationCell MovementCell ShapeCell Surface ExtensionsCell Surface ProjectionsCell Surface ProtrusionsCell membraneCellLineCellsCellular MatrixCellular MigrationCellular MotilityCessation of lifeClinicalCodeCoding SystemCortactin GeneCritical IllnessCritically IllCytoplasmic MembraneCytoskeletal SystemCytoskeletonDa Nang LungDeathDextransDiseaseDisorderDropsyDysfunctionEC 2.7.1.117EMS1EMS1 geneEdemaElectric ResistanceElectrical ResistanceEndothelial CellsEndotheliumFloodingFloodsFunctional disorderFutureGene variantGenerationsGenesGeneticGenetic predisposing factorGoalsHumanHydropsHypoxemiaImageImaging ProceduresImaging TechnicsImaging TechniquesImmune PrecipitationImmunofluorescence MicroscopyImmunoprecipitationIndividualInfectionInflammationInflammatoryInjuryIsoleucineKO miceKnock-out MiceKnockout MiceKnowledgeL-ValineLentiviral VectorLentivirus VectorLinkLiquid substanceLungLung Respiratory SystemLung damageMYLK2MaintenanceMeasurementMeasuresMembraneMiceMice MammalsMicrofilamentsModelingModern ManMolecular InteractionMonomeric G-ProteinsMonomeric GTP-Binding ProteinsMurineMusMyofilamentsMyosin IMyosin KinaseMyosin LCKMyosin Light Chain KinaseMyosin Light Chain Kinase, Smooth Muscle and Non-Muscle IsozymesMyosin Light Polypeptide KinaseMyosin Regulatory Light-Chain KinaseMyosin Type IMyosin light chain kinase 2, skeletal/cardiac muscleNull MouseOutcomePathologicPatientsPeripheralPermeabilityPhysiopathologyPlasma CellsPlasma MembranePlasmacytesPolymersProcessProteinsRecoveryRegulationRegulatory ProteinResearchRespiratory FailureRespiratory MechanicsRiskRoleShock LungShort interfering RNASignaling MoleculeSmall G-ProteinsSmall GTPasesSmall Interfering RNAStiff lungStrains Cell LinesStructureValineVariantVariationWorkallelic variantaminoacidcapillarycell motilityclinical relevanceclinically relevantcortactincultured cell linedeliver short interfering RNAdeliver siRNAdeliver small interfering RNAdelivery system for siRNAdelivery system for small interfering RNAdelivery vectors for siRNAdextranems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate))fluidgenetic regulatory proteingenetic risk factorgenetic variantgenomic varianthypoxemicimagingimprovedinherited factorinhibitorinjuriesinsightinterstitialintracellular skeletonknock-downknockdownliquidlung injurymembrane structuremigrationmortalitynew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetoverexpressoverexpressionpathophysiologyplasmalemmaplasmocytepolymerpolymericpolymerizationpre-clinical studypreclinical studypreventpreventingprotein complexpulmonarypulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryregulatory gene productshort interfering RNA deliverysiRNAsiRNA deliverysmall interfering RNA deliverysmooth muscle myosin light chain kinasesocial rolesubcellular fractionationvascularwet lung
Description preview
ABSTRACT
The acute respiratory distress syndrome (ARDS) is characterized by pulmonary vascular leak and
flooding of the normally air-filled alveolar space with protein rich edema fluid and causes severe hypoxemia,
respiratory failure and death among critically ill patients. Identification of genetic factors which modify the risk of
developing…
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