grant
Cardiovascular Immunology Research Core (Core B)
Organization UNIVERSITY OF ARIZONALocation TUCSON, UNITED STATESPosted 5 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY202521+ years oldAdaptor ProteinAdaptor Protein GeneAdaptor Signaling ProteinAdaptor Signaling Protein GeneAdultAdult HumanAntibodiesAntigen-Antibody ComplexBindingBiological FunctionBiological ProcessBody TissuesCardiacCardiac Muscle CellsCardiac MyocytesCardiocyteCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell AgingCell BodyCell Communication and SignalingCell Cycle ArrestCell SenescenceCell SignalingCellsCellular AgingCellular SenescenceCessation of lifeChromiumComplexConsultationsCr elementCyclic GMPDNAData AnalysesData AnalysisDeathDeoxyribonucleic AcidDigestionEnzyme GeneEnzymesEquipmentFailureFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGeneralized GrowthGenerationsGenomicsGoalsGrowthGuanosine Cyclic MonophosphateHeartHeart Muscle CellsHeart VascularHeart failureHeart myocyteHyperplasiaHyperplasticHypertrophyIFNImmuneImmune ComplexImmune responseImmunesImmunoblottingImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImmunologistImmunologyImmunology procedureInflammatory ResponseInjuryInnate Immune ResponseInnate ImmunityInterferon Type IInterferonsIntracellular Communication and SignalingIntracellular Second MessengerInvestigatorsIsomerismLifeLinkLogisticsMacrophageMediatingMedical centerModelingMolecular InteractionMyocardialMφNative ImmunityNatural ImmunityNatural regenerationNeonatalNon-Specific ImmunityNonspecific ImmunityPathway interactionsPlayProcessProductionProductivityProliferatingReagentRegenerationRegulationRejuvenationReplicative SenescenceResearchResearch DesignResearch PersonnelResearch ResourcesResearchersResource AllocationResourcesRoleSecond Messenger SystemsSecond MessengersServicesSignal TransductionSignal Transduction SystemsSignalingStimulator of Interferon GenesStudy TypeT-CellsT-LymphocyteTechnical ExpertiseTechniquesTherapeuticTissue GrowthTissuesTranscript Expression AnalysesTranscript Expression AnalysisTumor ImmunityVentricle RemodelingVentricular Cardiac RemodelingVentricular Myocardial RemodelingVentricular RemodelingVirusWestern BlottingWestern Immunoblottingadapter proteinadulthoodanalyze gene expressionanti-tumor immunityantitumor immunitybiological signal transductioncGAMP STINGcGAMP-STINGcGAMP/STINGcGAS/STINGcGMPcancer immunitycardiac failurecardiomyocytecirculatory systemconsultationcyclic GMP-AMP synthase/STINGdata interpretationdesigndesigningexperienceflow cytophotometrygain of functiongene expression analysisgene expression assayhealinghost responseimmune system responseimmunocytochemistryimmunologic assayimmunologic assay/testimmunoresponseinhibitorinjuriesinjury responseinnovateinnovationinnovativeinterestisomerloss of functionmeetingmeetingsmembermyocardial remodelingontogenypathwaypostnatalpreventpreventingprogramsprotein blottingregeneratereplicative agingresponse to injuryscRNA sequencingscRNA-seqsensorsignal transduction second messengerssingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskillssocial rolestudy designsuccesssynergismtechnical skillsthymus derived lymphocytetranscriptional profiling
Description preview
Heart failure progression is a complex biological process that is precipitated by the maladaptive myocardial
response to injury, compounded by failure of the adult heart to replace lost or damaged cardiomyocytes.
Conceivably, identifying common pathways that regulate these two seemingly unrelated processes would
profoundly impact therapeutic…
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