grant
Cardiopulmonary outcomes of dual cigarette and e-cigarette use in animal models of chronic exposure
Organization NORTHEASTERN UNIVERSITYLocation BOSTON, UNITED STATESPosted 18 May 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY202521+ years oldAPOEAcetylcholineAdultAdult HumanAerosolsAffectAirAirway ResistanceAllergen Bronchial Provocation TestsAmericanAnimal ModelAnimal Models and Related StudiesAnimalsAntigen Bronchial Provocation TestsAortaApo-EApoE proteinApolipoprotein EAreaArterial Fatty StreakAtheromaAtheromatousAtheromatous degenerationAtheromatous plaqueBioavailabilityBiological AvailabilityBloodBlood Reticuloendothelial SystemBody TissuesBronchial Allergen ChallengeBronchial Challenge TestsBronchial Provocation TestsC57BL/6 MouseCardiopulmonaryCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCategoriesCessation of lifeChemicalsChronicCigaretteCigarette SmokerClinicalCollagenCor pulmonaleCotinineDataDeathDepositDepositionDevicesDrug KineticsEFRACEjection FractionElastic FiberElasticityElectronic cigaretteEndobronchial Allergen ChallengeEndobronchial Challenge TestsEpidemiological dataEpidemiology dataEvaluationExposure toFDA approvedFSPTCAFamily Smoking Prevention and Tobacco Control ActGenerationsHealthHealth Care CostsHealth CostsHeartHeart VascularHeterogeneityHypercholesteremiaInhalationInhalation Provocation TestsInhalingJUULKnowledgeLeft VentriclesLeft ventricular structureLungLung Respiratory SystemMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasuresMechanicsMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMiceMice MammalsModelingMurineMusNMR ImagingNMR TomographyNasalNasal Passages NoseNebulizerNicotineNoseNuclear Magnetic Resonance ImagingO elementO2 elementOutcomeOxygenPharmacokineticsPhysiologic AvailabilityPropertyProxyPulmonary Body SystemPulmonary Heart DiseasePulmonary Heart DisorderPulmonary Organ SystemPulmonary imagingRegulationRelaxationReportingResearchResistanceRespiratory SystemRespiratory System, Nose, Nasal PassagesRespiratory TractsRespiratory tract structureRiskRisk FactorsSFRACSafetySaltsScotineShortening FractionSmokeSmokerSmokingSodium ChlorideSolventsSourceStructureSystemTestingTissuesTobaccoVirginiaWild Type MouseWork LoadWorkloadYouthYouth 10-21Zeugmatographyabdominal aortaabsorptionadulthoodaerosolizedaerosolized nicotineatherosclerosis plaqueatherosclerotic lesionsatherosclerotic plaquebasebasesbronchoprovocationcardiopulmonary diseasecardiopulmonary disordercardiovascular disordercardiovascular riskcardiovascular risk factorcease smokingcigarette smokecigarette smoke exposurecirculatory systemco-morbidco-morbiditycombustible cigarettecomorbidityconventional cigarettedesigndesigninge-cige-cig usee-cigarettee-cigarette useecigecig useecigaretteecigarette useelectronic cigarette useepidemiologic dataexperienceexperimentexperimental researchexperimental studyexperimentsexposure to cigarette smokehigh blood cholesterolhypercholesterolemiaimaging in miceimaging studies for miceimaging studies in miceinterestirritationlung imaginglung scanningmechanicmechanicalmechanical propertiesmethacholinemice imagingmodel of animalmouse modelmurine imagingmurine modelnebulizationnebulizenicotine cravingnicotine vaporplaques in atherosclerosispressurepulmonaryquit smokingresistantrespiratoryresponsesaltsmoke inhalationsmoking cessationsmoking-related diseasesmoking-related disorderstop smokingtobacco flavortobacco productstraditional cigarettetranslational opportunitiestranslational potentialvapingvapor containing nicotinevaporized nicotinewildtype mouseyouth age
Description preview
PROJECT SUMMARY
New generation pod-style nicotine salt e-cigarettes (e-cigspod) are popular because of their sleek design and
ability to deliver nicotine levels similar to those of conventional tobacco cigarettes (cigs). Nicotine salts are easier
to inhale than the free-base form of nicotine found in previous generation e-cigs. While the long-term…
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