grant
Cardiac microtubules as regulators of diastolic function.
Organization UNIVERSITY OF VERMONT & ST AGRIC COLLEGELocation BURLINGTON, UNITED STATESPosted 12 Dec 2023Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY2025AbscissionActomyosinAssayBasic ResearchBasic ScienceBioassayBiological AssayBiologyBiomechanicsCardiacCardiac DiseasesCardiac DisordersCardiac Muscle CellsCardiac MyocytesCardiocyteCardiomyopathiesCause of DeathClinicalClinical DataColchicineCollagenCommon Rat StrainsContracting OpportunitiesContractsCustomCyclicityCytoskeletal FilamentsDataDiastoleDrug TargetingDysfunctionEnzyme GeneEnzymesExcisionExhibitsExtirpationFDA approvedFibrosisFunctional disorderHealthHeartHeart DiseasesHeart Muscle CellsHeart failureHeart myocyteHistologyHypertensionHypertrophyImpairmentIsoformsLeft VentriclesLeft ventricular structureMechanicsMetabolic syndromeMicro-tubuleMicrotubulesMinorityModelingMolecularMuscleMuscle CellsMuscle TissueMyocardialMyocardial DiseasesMyocardial DisorderMyocardiopathiesMyocardiumMyocytesNational Institutes of HealthNetwork-basedOutputPerformancePeriodicityPhasePhysiologyPhysiopathologyPlayPreparationPropertyProtein IsoformsProteinsProteomicsProtocolProtocols documentationRatRats MammalsRattusRegulationRelaxationRemovalRhythmicityRoleSarcomeresSeriesSliceSpeedStretchingStructureSurgical RemovalTestingTranslatingTubulinUnited States National Institutes of HealthVascular Hypertensive DiseaseVascular Hypertensive DisorderVentricularWorkbiomechanicalcardiac failurecardiac musclecardiomyocyteconnectincustomsdensitydepolymerizationdesigndesigningdisabilityextracellularforce feedbackheart disorderheart musclehigh blood pressurehyperpiesiahyperpiesishypertensivehypertensive diseasehypertensive disorderimprovedmechanicmechanicalmechanical propertiesmuscularmyocardium diseasemyocardium disordernovelpathophysiologypreparationsresectionsocial rolesuperresolution imagingtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttitin
Description preview
Abstract
Diastolic heart disease (DHD) is the leading cause of death and disability worldwide. With no FDA approved
therapies to improve diastolic function, the NIH has placed special emphasis on collaborative initiatives bridging
basic science and clinical data to understanding the molecular mechanism of DHD. The hallmarks of diastolic
heart…
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