grant
Carbonic Anhydrase Mediated Regulation of Microtubule Dynamics and Infection in Cystic Fibrosis
Organization LURIE CHILDREN'S HOSPITAL OF CHICAGOLocation CHICAGO, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY20253-D modeling3D modelingActinsAddressAdherenceAdhesionsAffectAirway DiseaseAirway failureAirway infectionsAssayAutomobile DrivingAutoregulationAwardBacteriaBacterial AdhesionBicarbonatesBindingBioassayBiochemicalBioinformaticsBiologic ModelsBiological AssayBiological ModelsBiotinylationCF airwayCF patientsCFTRCFTR ProteinCarbonate hydro-lyaseCarbonic AnhydrasesCell BodyCell membraneCellsCellular MatrixCessation of lifeChildhoodChloridesChronicClinicalCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorCytoplasmic MembraneCytoskeletal ModelingCytoskeletal OrganizationCytoskeletal Organization ProcessCytoskeletal ReorganizationCytoskeletal SystemCytoskeletonDataData AnalysesData AnalysisDeathDefectDevelopmentDiseaseDisorderDysfunctionEndocytosisEnvironmentEpithelial CellsFacultyFunctional disorderFundingFutureGene variantGenesGeneticGenetic DiseasesGoalsHCO3HistoryHomeostasisHumanHydrogen CarbonatesImaging ProceduresImaging TechnicsImaging TechniquesImmune responseImpairmentIn VitroIndividualInfectionInfection ControlInflammationIntracellular MembranesIntracellular TransportInvestigationInvestigatorsIsoformsKnock-outKnockoutLeadLifeLinkLong-term infectionLungLung Respiratory SystemLung infectionsMediatingMediatorMembraneMentorshipMethodsMicro-tubuleMicroscopyMicrotubule PolymerizationMicrotubulesModel SystemModelingModern ManMolecular InteractionMotorMucous body substanceMucoviscidosisMucusNasal EpitheliumNetwork AnalysisObstructionOntologyOrganoidsOutcome StudyP aeruginosaP. aeruginosaPathway AnalysisPathway interactionsPb elementPersonsPhenotypePhysiological HomeostasisPhysiopathologyPlasma MembranePlayProtein FamilyProtein IsoformsProteinsProteomicsPseudomonas aeruginosaPseudomonas pyocyaneaRecording of previous eventsRegulationResearchResearch PersonnelResearchersRespiratory EpitheliumRespiratory FailureRespiratory InfectionsRespiratory Tract InfectionsRoleStructure of respiratory epitheliumSurfaceTechnical ExpertiseTestingTherapeuticTherapeutic InterventionTranslatingVariantVariationVesicleWorkWritingairflow limitationairflow obstructionairway epitheliumairway limitationairway obstructionallelic variantbacteria pathogenbacterial pathogencarbonate dehydratasecareerchronic infectionclinical phenotypecystic fibrosis airwaycystic fibrosis patientscystic fibrosis transmembrane regulatordata interpretationdevelopmentaldrivingeffective therapyeffective treatmentexome sequencingexome-seqgene manipulationgenetic conditiongenetic disordergenetic manipulationgenetic variantgenetically manipulategenetically perturbgenomic variantheavy metal Pbheavy metal leadhistorieshost microbe associationhost microbe relationshiphost responsehost-microbe interactionshost-microbial interactionshost-microorganism interactionsimmune system responseimmunoresponseimprovedindividuals with CFindividuals with cystic fibrosisinsightintervention therapyintracellular skeletonlive cell imagelive cell imaginglive cellular imagelive cellular imaginglung functionmembrane structuremicrobialmicrobial consortiamicrobial floramicrobiotamicrofloramucousmucus clearancemultispecies consortianew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetobstructed airflowobstructed airwayoverexpressoverexpressionpathogenpathogenic bacteriapathophysiologypathwaypatients with CFpatients with cystic fibrosispediatricpersistent infectionpharmacologicplasmalemmapre-clinicalpreclinicalprematureprematuritypreventpreventingprogramspulmonary functionpulmonary infectionsrespiratory airway obstructionrespiratory tract epitheliumresponseskillssocial roletargeted agenttargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttechnical skillstherapeutic targetthree-dimensional modelingtrafficking
Description preview
Project Summary
Cystic fibrosis (CF) is a genetic disease causing premature death, primarily due to respiratory failure from
increased inflammation and chronic infections. While therapies targeting the dysfunctional protein channel
have improved lung function and mucus clearance, infection remains a significant problem. This proposal
investigates…
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