grant

Carbon isotope exchange mediated by vanadium complexes

Organization FLORIDA INTERNATIONAL UNIVERSITYLocation MIAMI, UNITED STATESPosted 1 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AlkenesAreaBiologyC-14C14 isotopeCarbonCarbon IsotopesCarbon-14ChemistryClinical Drug DevelopmentClinical Drug Testing/DevelopmentCollectionComplexDevelopmentDrug KineticsDrugsEthylenesIsotope LabelingIsotopesLabelMediatingMedicationMedicineMetabolicMethodsNatural ProductsOlefinsPETPET ScanPET imagingPETSCANPETTPharmaceutical AgentPharmaceutical PreparationsPharmaceuticalsPharmacokineticsPharmacologic SubstancePharmacological SubstancePositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyProceduresProcessProtocolProtocols documentationRad.-PETSourceTransition ElementsV elementVanadiumWorkcatalystclinical drug development/testingdehydrogenationdesigndesigningdevelopmentaldrug candidatedrug/agentethenefunctional groupinnovateinnovationinnovativeiodomethaneisotope incorporationmethyl groupmethyl iodidenaturally occurring productpharmaceuticalpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypre-clinicalpreclinicaltooltransition metal
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Description preview

Project Summary
The proposed studies focus on the design, synthesis, and development of a range of vanadium-

based catalysts to perform carbon isotope exchange via =*CH2 (*C = 11C, 13C, and 14C) group transfer

between terminal olefins. Carbon isotope exchange is an emerging area that allows incorporating carbon-

14 isotope directly into target…

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