grant
CAR neutrophils produced in vivo to remodel tumor microenvironment and treat glioblastoma
Organization PURDUE UNIVERSITYLocation WEST LAFAYETTE, UNITED STATESPosted 21 Apr 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2026AbscissionAdoptive Cell TransfersAnimal HospitalsAnimal ModelAnimal Models and Related StudiesAnimalsBBB crossingBBB penetrationBindingBloodBlood - brain barrier anatomyBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood Reticuloendothelial SystemBlood-Brain BarrierBrainBrain CancerBrain DiseasesBrain DisordersBrain GlioblastomaBrain Glioblastoma MultiformeBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain TumorsCAR NKCAR T cell therapyCAR T cellsCAR T therapyCAR modified T cellsCAR-TCAR-TsCD3CD3 AntigensCD3 ComplexCD3 moleculeCLG4CLG4ACancer TreatmentCancersCanine SpeciesCanis familiarisCell BodyCell Communication and SignalingCell SignalingCellsCellular immunotherapyChlorotoxinClinical ResearchClinical StudyClinical TrialsCollaborationsCollectionComplexDAP12DNA mutationDataDogsDogs MammalsDrugsEffector CellEncephalonEncephalon DiseasesEngineeringExcisionExtirpationFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGenerationsGenetic ChangeGenetic defectGenetic mutationGlial Cell TumorsGlial NeoplasmGlial TumorGlioblastomaGliomaGoalsGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaGrade IV Brain Astrocytic NeoplasmGrade IV Brain Astrocytic TumorGrade IV Brain AstrocytomaHemato-Encephalic BarrierHistologyHumanHuman ActivitiesImageImmuneImmune mediated therapyImmunesImmunologically Directed TherapyImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunotherapeutic agentImmunotherapyIn VitroIncrease lifespanInterpretable MLInterpretable machine learningIntracellular Communication and SignalingIntracranial CNS DisordersIntracranial Central Nervous System DisordersInvestigatorsKARAPKnowledgeLibrariesMMP2MMP2 geneMachine LearningMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMalignant Tumor of the BrainMalignant neoplasm of brainMarrow NeutrophilMedicationMessenger RNAMiceMice MammalsModern ManMolecular InteractionMurineMusMutationNGS MethodNGS systemNK T cell immunotherapyNK T cell therapyNKT cell immunotherapyNKT cell therapyNatural Killer T cell TherapyNeuroglial NeoplasmNeuroglial TumorNeutrophilic GranulocyteNeutrophilic LeukocyteNucleosidesOKT3 antigenOperative ProceduresOperative Surgical ProceduresPLO-SLPLOSLPaperPatientsPeptidesPharmaceutical PreparationsPhenotypePhysiologicPhysiologicalPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulationProcessQOLQuality of lifeQuestionnairesRadiationRadiation therapyRadiotherapeuticsRadiotherapyReceptor SignalingRecurrenceRecurrentRemovalResearch PersonnelResearchersSafetySignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSolid NeoplasmSolid TumorSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalSystemT cells for CART3 AntigensT3 ComplexT3 moleculeTBE-1TYROBPTYROBP geneTestingTherapeuticTherapeutic EffectTimeToxic effectToxicitiesTrainingTreatment EfficacyVeterinary ClinicsVeterinary HospitalsWorkXenograft Modeladoptive cell therapyadoptive cellular therapyanti-cancer therapeuticanti-cancer therapybiological signal transductionblood-brain barrier crossingblood-brain barrier penetrationblood-brain tumor barrierblood-tumor barrierbloodbrain barrierbloodbrain barrier crossingbloodbrain barrier penetrationbloodbrain tumor barrierboost longevitybrain parenchymabrain remodelingcancer microenvironmentcancer progressioncancer therapycancer typecancer-directed therapycaninecanine animal modelcanine modelcell-based immunotherapycheck point blockadecheckpoint blockadechimeric antigen T cell receptorchimeric antigen receptorchimeric antigen receptor (CAR) T cell therapychimeric antigen receptor (CAR) T cellschimeric antigen receptor Tchimeric antigen receptor T cell therapychimeric antigen receptor T cellschimeric antigen receptor T therapychimeric antigen receptor engineered natural killer cellchimeric antigen receptor fusion protein T-cellschimeric antigen receptor modified T cellschimeric antigen receptor natural killer cellscombinatorialdesigndesigningdevelop therapydog modeldomestic dogdrug/agentelongating the lifespanengineered T cellsengineered exosomesenhance longevityexosomeexplainable MLexplainable machine learningextend life spanextend lifespanextend longevityflow cytophotometryfoster longevitygenetically engineered T-cellsgenome mutationglial-derived tumorglioblastoma multiformeglioblastoma multiforme brain tumorshuman derived pluripotent stem cellhuman pluripotent stem cellhumanized micehumanized mouseimagingimmune cell therapyimmune check point blockadeimmune checkpoint blockadeimmune drugsimmune microenvironmentimmune suppressionimmune suppressive activityimmune suppressive functionimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapeuticsimmune-based therapiesimmune-based treatmentsimmuno therapyimmunologic therapeuticsimmunosuppressive activityimmunosuppressive functionimmunosuppressive microenvironmentimmunosuppressive responseimmunosuppressive tumor microenvironmentimmunotherapeuticsimmunotherapy agentimprove lifespanimprove longevityimprovedin vivoinnovateinnovationinnovativeintervention developmentintervention efficacyintravenous injectionlifespan extensionlipid based nanoparticlelipid nanoparticlemRNAmachine based learningmachine learned algorithmmachine learning algorithmmachine learning based algorithmmalignancymigrationmodel of animalmouse modelmurine modelnatural killer T cell immunotherapynatural killer cells expressing chimeric antigen receptorsnatural killer cells with chimeric antigen receptorsneoplasm progressionneoplasm/cancerneoplastic progressionneural networkneuroglia neoplasmneuroglia tumorneutrophilnew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext gen sequencingnext generation sequencingnext generation therapeuticsnextgen sequencingnovelnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapyperipheral bloodpre-clinicalpreclinicalprogramsprolong lifespanprolong longevitypromote lifespanpromote longevityradiation treatmentrecruitresectionresistance to therapyresistant to therapyscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsite targeted deliveryspongioblastoma multiformestandard carestandard of carestandard treatmentsupport longevitysurgerysynthetic biologytargeted deliverytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic efficacytherapeutic resistancetherapy developmenttherapy efficacytherapy resistanttooltransgenic T- cellstranslational applicationstreatment developmenttreatment resistancetreatment with radiationtumortumor immune microenvironmenttumor microenvironmenttumor progressiontumor-immune system interactionstumors in the brainxenograft transplant modelxenotransplant model
Description preview
Project Summary
Glioblastoma (GBM) is the most aggressive type of cancer that occurs in the brain. While functional anti-
cancer therapeutics, such as emerging chimeric antigen receptor (CAR)-T and natural killer (NK) cell therapies,
have been developed to treat various cancers, their therapeutic applications for brain cancers have been
impeded…
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