grant

Capturing social and cognitive health dynamics as digital risk biomarkers of Alzheimer's disease

Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 15 Sept 2025Deadline 14 Sept 2029
NIHUS FederalResearch GrantFY202521+ years oldAD related dementiaADRDAddressAdultAdult HumanAffectiveAgingAlcohol DrinkingAlcohol consumptionAlzheimer risk factorAlzheimer's and related dementiasAlzheimer's biomarkerAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease biological markerAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimer’s biological markerAlzheimer’s disease biomarkerAttentionBehaviorBehavior Conditioning TherapyBehavior ModificationBehavior TherapyBehavior TreatmentBehavioralBehavioral Conditioning TherapyBehavioral ModificationBehavioral TherapyBehavioral TreatmentBiological MarkersBiometricsBiometryBiostatisticsCaliforniaClinicalCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalConditioning TherapyDataDevelopmentDiagnosisDigital biomarkerDimensionsDisturbance in cognitionEarly DiagnosisEcological momentary assessmentEmpirical ResearchEnsureEnvironmentEpidemicEtOH drinkingEtOH useEthnic OriginEthnicityExhibitsFutureGoalsHealthHealth PsychologyImmediate MemoryImpaired cognitionIndividualIndividual DifferencesInfrastructureInterventionInvestigatorsKnowledgeLifeLinkLonelinessLong-Term EffectsMachine LearningMapsMeasurementMeasuresMediatingMediatorMethodologyModelingMonitorNeuropsychologiesNeuropsychologyPathogenesisPathway interactionsPatient Self-ReportPersonalityPersonsPhysical activityPopulationPopulation ForecastsPopulation ProjectionPredictive FactorPsychometricsPublic HealthRaceRacesReactionResearchResearch PersonnelResearchersRiskRisk AssessmentRisk FactorsSamplingSelf-ReportShort-Term MemorySleepSmokingSocial ProcessesSocial isolationSocial supportStratificationStressTestingTheoretic ModelsTheoretical modelUnited StatesUniversitiesVariantVariationWorkadulthoodalcohol ingestionalcohol intakealcohol product usealcohol usealcoholic beverage consumptionalcoholic drink intakealzheimer riskauthoritybehavior interventionbehavioral interventionbio-markersbiologic markerbiomarkerbiomarker developmentcognitive dysfunctioncognitive losscognitive performancedata harmonizationdementia burdendementia riskdemographicsdevelopmentaldigitaldigital markerdigital technologyearly detectionethanol consumptionethanol drinkingethanol ingestionethanol intakeethanol product useethanol useexecutive controlexecutive functionexperiencegermineharmonized datahealthy aginghealthy human aginginnovateinnovationinnovativeinsightinstrumentlack of physical activitylonelylongitudinal designlongitudinal experimental designlongitudinal research designlongitudinal study designmachine based learningmachine learning based modelmachine learning modelmid lifemid-lifemiddle agemiddle agedmidlifemobile assessmentmobile based assessmentneuropsychologicnovelopen sourcepathwayphysical inactivityprocessing speedpsychosocialracialracial backgroundracial originrecruitrisk factor for dementiarisk for dementiascreeningscreeningsskillssmart phone based assessmentsmartphone based assessmentsocialsocial determinantssocial support networksociodeterminanttheoriestoolworking memory
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Poor social health (high loneliness, high social isolation, low social support) is associated with heightened risk for Alzheimer's disease and related dementias (AD/ADRDs). Theoretical models posit that social health's long-term effects on cognition result from cumulative risks associated with short-term, dynamic social processes. For example,…

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Capturing social and cognitive health dynamics as digital risk biomarkers of Alzheimer's disease — UNIVERSITY OF CALIFOR | Dev Procure