grant
Cannabinoid inhibition of CNS inflammasome activation via modulation of the gut-brain axis
Organization UNIVERSITY OF NEBRASKA MEDICAL CENTERLocation OMAHA, UNITED STATESPosted 15 Apr 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY202518-FDG18F- FDG18FDG2 Fluoro 2 deoxy D glucose2,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors2-Fluoro-2-deoxyglucose9-ene-TetrahydrocannabinolAH ReceptorsAIDS VirusAIDS/HIVAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAffectAgonistAlimentary CanalAminoacetic AcidAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryApoptosis-Related Cysteine Protease Caspase 1ApoptoticAryl Hydrocarbon ReceptorAutophagocytosisAutopsyBBB crossingBS-seqBasal GangliaBasal NucleiBehaviorBeta Proprotein Interleukin 1BindingBisulfite-based sequencingBlood PlasmaBlood monocyteBrainBrain Nervous SystemCASP-1CASP1CASP1 geneCB1CB1 ReceptorCB1RCB2CB2 ReceptorCB2RCNR1 geneCNR2CNR2 geneCannabinoid Receptor CB1Cannabinoid Receptor CB2CannabinoidsCaspaseCaspase GeneCaspase-1Caspase-1 GeneCell Communication and SignalingCell DeathCell SignalingCell-Death ProteaseCellular Immune FunctionCellular StressCellular Stress ResponseChemicalsChronicCocaineCocaine use disorderColonCysteine EndopeptidasesCysteine ProteaseCysteine ProteinasesD9-tetrahydrocannabinolDNADNA MethylationDataDegenerative Neurologic DisordersDelta-9-TetrahydrocannabinolDeoxyribonucleic AcidDevelopmentDiagnosisDigestive TractDioxin ReceptorsDioxygenasesDiseaseDisease ProgressionDisorderDoseDrugsEncephalonEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpithelial CellsEpitheliumFamilyGI TractGastrointestinal TractGastrointestinal tract structureGene ExpressionGenesGlycineHIVHIV 1 associated neurocognitive disorderHIV associated neurocognitive deficitHIV associated neurocognitive impairmentHIV induced neurocognitive deficitHIV induced neurocognitive impairmentHIV neurocognitive impairmentHIV-1 associated neurocognitive deficitHIV-1 associated neurocognitive disorderHIV-1 associated neurocognitive impairmentHIV-associated neurocognitive disorderHIV/AIDSHigh PrevalenceHortega cellHumanHuman Immunodeficiency VirusesHypermethylationICE ProteaseICE-like proteaseIFNIFN-Gamma-Inducing Factor GeneIFN-gamma-Inducing FactorIGIFIGIF GeneIL-1 GammaIL-1 Gamma GeneIL-1 betaIL-1 beta ConvertaseIL-1 beta-Converting EnzymeIL-1 βIL-1-bIL-18IL-18 GeneIL-1BCIL-1b Converting EnzymeIL-1gIL-1g GeneIL-1βIL1-BetaIL1-βIL18IL18 ProteinIL18 geneIL1B ProteinIL1B-ConvertaseIL1BCIL1BCEIL1F2IL1F4IL1F4 GeneIL1βImmune Cell ActivationImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmunofluorescenceImmunofluorescence ImmunologicImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunomodulationIn VitroIndividualIndolesInfectionInflammasomeInflammationInflammatoryInflammatory ResponseInnate Immune ResponseInterferon-Gamma-Inducing Factor GeneInterferon-gamma-Inducing FactorInterferonsInterleukin 1-B Converting EnzymeInterleukin 1-Beta ConvertaseInterleukin 18 (Interferon-Gamma-Inducing Factor)Interleukin 18 (Interferon-Gamma-Inducing Factor) GeneInterleukin 18 ProproteinInterleukin 18 Proprotein GeneInterleukin 1betaInterleukin-1 Beta Converting EnzymeInterleukin-1 Converting EnzymeInterleukin-1 GammaInterleukin-1 Gamma GeneInterleukin-1 betaInterleukin-18Interleukin-18 PrecursorInterleukin-18 Precursor GeneInterleukin-1βInterventionIntestinalIntestinesIntracellular Communication and SignalingLAV-HTLV-IIILevarterenolLevonorepinephrineLinkLymphadenopathy-Associated VirusMEFV gene productMGC12320MGC12320 GeneMacromolecular Protein ComplexesMarrow monocyteMediatingMedicationMessenger RNAMiceMice MammalsMicrogliaModern ManMolecularMolecular InteractionMultiprotein ComplexesMurineMusNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurocognitive Impairment in HIVNeurocognitive Impairment in HIV-1Neurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeurologic DysfunctionsNoradrenalineNorepinephrineNuclear TranslocatorOrganPET/CTPET/CT scanPathogenesisPathogenicityPathway interactionsPersonsPharmaceutical PreparationsPlasmaPlasma SerumPolyaromatic Hydrocarbon ReceptorsPreinterleukin 1 BetaProductionPropertyPropionatesProteobacteriaPurple BacteriaRIP1RIP3RIPK1RIPK1 geneRIPK3RIPK3 geneReceptor ProteinReceptor-Interacting Protein 3Receptor-Interacting Serine/Threonine Kinase 1Receptor-Interacting Serine/Threonine Protein Kinase 3Reticuloendothelial System, Serum, PlasmaRisk FactorsSIVSignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSimian Immunodeficiency VirusesSiteT-CellsT-LymphocyteTCDD ReceptorsTestingTetTetanus Helper PeptideTetrahydrocannabinolTherapeuticTransmissionUpregulationViralVirus-HIVaddictionaddictive disorderalimentary tractantiretroviral therapyantiretroviral treatmentautophagybiological signal transductionbisulfite sequencingbisulfite-seqblood-brain barrier crossingbloodbrain barrier crossingbowelcannabinoid receptor 1cannabinoid receptor 2cannabinoid receptor type 1cannabinoid receptor type 2cannabinoid type 1cell stresschallenge in rhesus macaquesco-morbidco-morbiditycocaine usecomorbiditycystein proteasecystein proteinasecysteine endopeptidasedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdelta(1)-THCdelta(1)-Tetrahydrocannabinoldelta(9)-THCdelta(9)-Tetrahydrocannabinoldevelopmentaldigestive canaldrug/agentdysbacteriosisdysbiosisdysbioticepigenetic regulationepigeneticallyfluorodeoxyglucosegitter cellgut dysbiosisgut to brain axisgut-brain axisgut-brain communicationgut-brain interactionsgut-brain relationshipgut-brain signalingimmune activationimmune functionimmune modulationimmune regulationimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryinfected rhesus macaquesinfected rhesus monkeyinfection in rhesus macaquesinfection of rhesus macaquesinhibitorlipophilicitymRNAmarenostrinmesogliamicrobialmicrobial imbalancemicrobiota-gut-brain axismicrobiota-gut-brain interactionsmicrobiota-gut-brain signalingmicroglial cellmicrogliocytemonocytenecrocytosisnecropsyneural inflammationneurodegenerative illnessneuroinflammationneuroinflammatoryneurological dysfunctionneuroprotectionneuroprotectivepathwayperivascular glial cellpositron emission computed tomographypostmortempreventpreventingpromoterpromotorprotein expressionpsychostimulantpyrinreceptorrhesus challengerhesus macaque challengerhesus monkey infectiontherapy adherencetherapy compliancethymus derived lymphocytetransmission processΔ(1)-THCΔ(1)-tetrahydrocannabinolΔ(9)-THCΔ(9)-tetrahydrocannabinolΔ-9-tetrahydrocannabinolΔ9-tetrahydrocannabinol
Description preview
ABSTRACT
The primary objective of this proposal is to investigate Cocaine/HIV/SIV induced changes in inflammasome
activation and their epigenetic regulation in the intestine and brain and its modulation by long-term, low-dose
cannabinoids and combination antiretroviral therapy. The NLRP3 (NOD-like receptor family, pyrin domain
containing)…
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