grant
CaMKII Holoenzyme Mechanisms in Opposing Forms of Synaptic Plasticity
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 1 Jul 2013Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026AddressAffinityAmmon HornAngelman SyndromeBindingBrainBrain Nervous SystemCAIN GeneCAN ProteinCAN geneCa(2+)-Calmodulin Dependent Protein KinaseCaM KIICaM PK IICaM kinase IICaMKCaMKIICalcium-Dependent Activator ProteinCalcium-Dependent RegulatorCalcium/calmodulin-dependent protein kinaseCalmodulinCalmodulin-Dependent Protein KinasesCalmodulin-KinaseCell Communication and SignalingCell SignalingCognitionCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCornu AmmonisD9S46EDataDisturbance in cognitionEncephalonFAST KinaseFAST geneFAST proteinFASTKFASTK GeneFLJ13079Fas-activated serine-threonine kinaseFeedbackFrequenciesFundingGlutamate ReceptorHappy Puppet SyndromeHippocampusHoloenzymesImpaired cognitionImpairmentIn VitroIntellectual disabilityIntellectual functioning disabilityIntellectual limitationIntracellular Communication and SignalingKIAA0023KineticsLearningLeftLong-Term DepressionLong-Term PotentiationLong-Term Synaptic DepressionMediatingMemoryMental DepressionMolecular ComputationsMolecular InteractionN Methyl D aspartic AcidN methyl D aspartateN-Methyl-D-aspartateN-MethylaspartateNMDANUP214NUP214 geneNerve CellsNerve UnitNeural CellNeurocyteNeuronsNucleoporin 214kDaNucleoporin, 214-KDOutputPathologicPerceptionPhosphodiesterase Activating FactorPhosphodiesterase Protein ActivatorPhosphorylationPhysical condensationPreventionProtein PhosphorylationPuppet ChildrenReactionRegulationRoleSchizophreniaSchizophrenic DisordersSignal TransductionSignal Transduction SystemsSignalingSpeedStructureSynapsesSynapticSynaptic plasticityTailTestingWorkbiological signal transductionbrain cellcalcium-calmodulin-dependent PKcalcium-calmodulin-dependent PK type IIcalcium-dependent CaM kinase IIcalmodulin dependent protein kinasecalmodulin-dependent protein kinase IIcognitive dysfunctioncognitive losscondensationdementia praecoxdepressiondimerhippocampalinformation processingintellectual and developmental disabilitylimited intellectual functioningmicrotubule associated protein 2 kinasemonomerneuronalpreferenceprotein kinase IIpuppetlike syndromeschizophrenicsocial rolesynapsetool
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Project Summary/Abstract
Stimulation of hippocampal NMDA-type glutamate receptors (NMDARs) can induce long-term potentiation
(LTP) or depression (LTD), two opposing forms of synaptic plasticity that are thought to be required for higher
brain functions such as learning, memory and cognition. This proposal will focus on the molecular computation…
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