grant
Calmodulin and Regulation of Cardiac Ryanodine Receptor and CaMKII
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 1 Jan 2010Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAffinityAmericanAnimal ModelAnimal Models and Related StudiesArrhythmiaAssayBindingBioassayBiological AssayBiophysicsCa Release Channel-Ryanodine ReceptorCalciumCalcium-Dependent Activator ProteinCalcium-Dependent RegulatorCalcium-Ryanodine Receptor ComplexCalmodulinCardiacCardiac ArrhythmiaCardiac DiseasesCardiac DisordersCardiac Muscle CellsCardiac MyocytesCardiocyteCatsCats MammalsCell Communication and SignalingCell SignalingChronicCryo-electron MicroscopyCryoelectron MicroscopyCrystallographiesCrystallographyCytoplasmDantroleneDataDefectDiabetes MellitusDiastoleDiseaseDisorderDomestic CatsDysfunctionElectron CryomicroscopyEnvironmentEnzyme GeneEnzymesFK-506-Binding ProteinFK506 Binding ProteinsFKBPFKBP RotamaseFRETFeedbackFeline SpeciesFelis catusFelis domesticaFelis domesticusFelis sylvestris catusFluorescenceFluorescence Resonance Energy TransferFunctional disorderFörster Resonance Energy TransferGoalsHealthHeartHeart ArrhythmiasHeart DiseasesHeart Muscle CellsHeart failureHeart myocyteHigh Throughput AssayHumanImageIntracellular Communication and SignalingKinasesKineticsMapsMeasuresMemoryMetabolic GlycosylationModern ManMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMovementMuscle CellsMyocytesNodalPathologicPathologyPathway interactionsPhosphodiesterase Activating FactorPhosphodiesterase Protein ActivatorPhosphorylationPhosphotransferase GenePhosphotransferasesPhysiologicPhysiologicalPhysiopathologyPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPropertyProtein ModificationProtein PhosphorylationReceptor InhibitionRegulationReporterResearchResolutionRyanodine ReceptorRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumSignal TransductionSignal Transduction SystemsSignalingStressStructureSystoleTacrolimus Binding ProteinsTestingTherapeuticTimeTransphosphorylasesVentricularWorkadulthoodanimationbiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencesbody movementcardiac failurecardiomyocytecatsconfocal imagingconformationconformationalconformational stateconformationallyconformationscryo-EMcryoEMcryogenic electron microscopydiabetesdrug candidatedrug discoverydrug-like chemicaldrug-like compounddrug-like moleculeglycosylationheart disorderhigh throughput screeningimaginginsightmodel of animalnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachoxidationpathophysiologypathwayresolutionsscreeningscreening programscreeningssensorstopped-flow fluorescencesynergismtherapeutic targettoolvalidation studies
Description preview
SUMMARY
Our overall goal is to understand the structural mechanisms for functional regulation of the cardiac
ryanodine receptor (RyR2) and Ca/calmodulin-dependent kinase (CaMKII), two central signaling nodes
causally implicated in numerous cardiac pathologies, including heart failure (HF) and arrhythmias. Our focus is
on pathological states and…
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