grant
Calciprotein Particles and Vascular Calcification in Patients with Chronic Kidney Disease
Organization ALBERT EINSTEIN COLLEGE OF MEDICINELocation BRONX, UNITED STATESPosted 1 Jan 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2025Active Follow-upAffectAortaArterial Fatty StreakArterial MediaArterial MediasArteriesAtheromaAtheromatousAtheromatous degenerationAtheromatous plaqueAttenuatedBloodBlood Reticuloendothelial SystemBlood SerumBlood VesselsBone FormationBone MineralizationBovine SpeciesBreast MicrocalcificationCAT scanCT X RayCT XrayCT imagingCT scanCalcifiedCardiac arteryCattleCell BodyCell CommunicationCell FunctionCell InteractionCell PhysiologyCell ProcessCell-to-Cell InteractionCellsCellular FunctionCellular PhysiologyCellular ProcessChronic Kidney FailureChronic Kidney InsufficiencyChronic Renal DiseaseChronic Renal FailureChronic Renal InsufficiencyCo-cultureCocultivationCocultureCoculture TechniquesComputed TomographyCoronary arteryDevelopmentEarly DiagnosisEarly InterventionEndogenous Nitrate VasodilatorEndothelial CellsEndotheliumEndothelium-Derived Nitric OxideExposure toFutureHeart arteryHemostasisHemostatic functionHumanIn VitroInflammationInterventionKnowledgeLeadLeiomyocyteLong-term prospective studiesMeasuresMediatingMethodsMicrocalcificationModern ManMononitrogen MonoxideNitric OxideNitrogen MonoxideNitrogen ProtoxideOsteogenesisPETPET ScanPET imagingPETSCANPETTParticle SizePathogenicityPatient RecruitmentsPatientsPb elementPhysiologic calcificationPlayPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPredispositionProcessProductionProteomicsRad.-PETResearch ProposalsRoleSamplingSerumSerum MarkersSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellSodium FluorideSubcellular ProcessSusceptibilitySystemTestingTimeTomodensitometryVascular Smooth MuscleVascular calcificationX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyXray CAT scanXray Computed TomographyXray computerized tomographyactive followupatherosclerosis plaqueatherosclerotic lesionsatherosclerotic plaqueattenuateattenuatesbone healthbone tissue formationbovidbovinecalcificationcalcification inhibitorcalcium phosphatecardiovascular riskcardiovascular risk factorcatscanchronic kidney diseasecohortcomputed axial tomographycomputer tomographycomputerized axial tomographycomputerized tomographycoronary artery calcificationcoronary calcificationcowdevelopmentalearly detectioneffective therapyeffective treatmentendothelial cell derived relaxing factorendothelial dysfunctionfollow upfollow-upfollowed upfollowupheavy metal Pbheavy metal leadhigh risk grouphigh risk individualhigh risk peoplehigh risk populationinsightlongitudinal, prospective studymineralizationmortalitynano particlenano-sized particlenanoparticlenanosized particlenon-contrast CTnoncontrast CTnoncontrast computed tomographynovelosteogenicparacrineparticipant recruitmentparticleplaques in atherosclerosispositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypre-clinical studypreclinical studypreventpreventingprospectiveresponsesocial rolestudy populationtherapeutic targettranslational opportunitiestranslational potentialuptakevascular
Description preview
PROJECT SUMMARY
Vascular calcification is common in patients with chronic kidney disease (CKD) and contributes to mortality.
Calciprotein particles (CPPs) have emerged as a promising therapeutic target. In CKD, excess CPPs build up
in the blood and transform into pathogenic forms—primary and secondary CPPs, which have been shown in
preclinical…
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