grant
C. officinalis induction of Nrf2 inhibiting type 1 diabetes
Organization UNIVERSITY OF SOUTH FLORIDALocation TAMPA, UNITED STATESPosted 25 Mar 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY20260-11 years old21+ years oldActive OxygenAddressAdultAdult HumanAnimal ModelAnimal Models and Related StudiesAnti-diabetic AgentsAnti-diabetic DrugsAntioxidantsAppearanceAutoimmune DiseasesAutoimmune StatusAutoimmunityAutophagocytosisBasal Transcription FactorBasal transcription factor genesBeta CellBiologicalBotanical natural productsBrittle Diabetes MellitusCell BodyCell Communication and SignalingCell DeathCell FunctionCell LineCell PhysiologyCell ProcessCell SignalingCell SurvivalCell ViabilityCellLineCellsCellular FunctionCellular PhysiologyCellular ProcessChildChild YouthChildren (0-21)ClinicalCornusD-GlucoseDependenceDevelopmentDextroseDiseaseDisorderEC 6.3.2.2ERYF1Early treatmentEthnopharmacologyExperimental DesignsFemaleGATA Binding Protein 1GATA-1GATA1GATA1 geneGATA1 proteinGATA1 transcription factorGF-1 proteinGamma-Glutamylcysteinyl SynthetaseGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic propensityGlucoseGlutamate-Cysteine LigaseGlutamylcysteine SynthetaseGlutathione ReductaseHO-1 enzymeHO1HO2HSP32Herbal MedicineHumanHumulin RHydrogen OxideHyperglycemiaIDDMIPO-BIn VitroInbred NOD MiceIncidenceIndophenol Oxidase BInherited PredispositionInherited SusceptibilityInsulinInsulin CellInsulin Secreting CellInsulin-Dependent Diabetes MellitusInterventionIntervention StrategiesIntracellular Communication and SignalingJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusLiteratureMNSODManganese Superoxide DismutaseMeasuresMediatingMethodsMiceMice MammalsMitochondrial Superoxide DismutaseMn Superoxide DismutaseMn-SODModalityModelingModern ManMolecularMurineMusNF-E1 erythroid-specific transcription factorNF-E2 proteinNF-E2 transcription factorNFE1 proteinNFE2 proteinNOD MouseNon obeseNon-Obese Diabetic MiceNonobeseNonobese Diabetic MouseNovolin RNuclear TranslocationOralOral ExaminationOxidative StressOxygen RadicalsPancreasPancreaticPancreatic beta CellPancreatic β-CellPathogenesisPathway interactionsPatientsPharmacologic ActionsPlant natural productPlant-based Natural ProductPlant-derived natural productsPreventative interventionPreventative measurePreventative treatmentPreventive measurePreventive treatmentPro-OxidantsProductionProteinsProteomicsReactive Oxygen SpeciesReadingRegular InsulinReportingResearchResearch DesignRoleSOD2SOD2 geneSTZSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSourceStrains Cell LinesStreptozocinStreptozotocinStructure of beta Cell of isletStudy TypeSubcellular ProcessSudden-Onset Diabetes MellitusSuperoxide Dismutase 2SymptomsT1 DMT1 diabetesT1DT1DMTechnologyTherapeuticTherapeutic InterventionToxic effectToxicitiesTranscription Factor GATA1Transcription Factor Proto-OncogeneTranscription factor genesType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusUnited StatesWaterZanosaradulthoodanti-diabeticautoimmune conditionautoimmune disorderautoimmunity diseaseautophagybiologicbiological signal transductionclinical efficacycultured cell linecytokinecytotoxicdesigndesigningdevelopmentaldiabetes pathogenesisdiabeticdrug developmentdrug resourceearly therapygamma-Glutamyl-Cysteine Synthetasegenetic vulnerabilitygenetically predisposedglobin transcription factor 1heme oxygenase-1hemeoxygenase 1hyperglycemicin vivoinnovateinnovationinnovativeinsulin dependent diabetesinsulin dependent diabetes mellitus onsetinsulin dependent type 1insulitisinterdisciplinary approachintervention for preventionintervention therapyisletjuvenile diabetesjuvenile diabetes mellitusketosis prone diabeteskidsmalemodel of animalmultidisciplinary approachnecrocytosisnon-obese diabetic (NOD) micenonobese diabetic (NOD) micenovelnuclear factor-erythroid 1nuclear factor-erythroid 2pancreas beta cellpancreas β cellpancreatic b-cellpathwaypharmacologicpre-clinicalpreclinicalpredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerpreservationpreventpreventingprevention interventionpreventional intervention strategypreventive interventionprotein expressionsocial rolestudy designtherapeutic candidatetranscription factortranscription factor NFE-1treatment grouptype 1 diabetes onsettype I diabetestype one diabetesyoungsterβ-cellβ-cellsβCell♀♂
Description preview
7. Project Summary/Abstract
Type 1 diabetes (T1D) is an autoimmune disease initiated by genetic predisposition and environmental
influences culminating in the destruction of pancreatic β-cells with irreversible loss of insulin production. Despite
strong predictive biomarkers of T1D, there is no cure and only one recently approved interventional…
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