grant
C. albicans-intrinsic mechanisms defining gut colonization
Organization BROWN UNIVERSITYLocation PROVIDENCE, UNITED STATESPosted 1 Aug 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025Alimentary CanalAntibiotic AgentsAntibiotic DrugsAntibiotic TherapyAntibiotic TreatmentAntibioticsAttentionBacteriaBehaviorC albicansC. albicansC.albicansCandida albicansCell BodyCellsDevelopmentDigestive TractEnvironmentEpithelial CellsExhibitsGI TractGI colonizationGI commensalGastrointestinal TractGastrointestinal tract structureGenesHealthHumanImmuneImmune responseImmunesInfectionMiceMice MammalsMiscellaneous AntibioticModelingModern ManMorphologyMucosaMucosal TissueMucous MembraneMurineMusOrganismParentsPlayPopulationRoleSupplementationSymbiosisSystemic diseaseToxinYeastsalimentary tractbacterial communitybacterial disease treatmentbacterial infectious disease treatmentcell typecommensal bacteria in the gastrointestinal tractcommensal bacteria in the gutcommensal bacteria in the intestinecommensalismdevelopmentaldigestive canalenteric commensalexperimentexperimental researchexperimental studyexperimentsfitnessfungal pathogenfungi pathogenfungusgastrointestinalgastrointestinal commensalgastrointestinal tract colonizationgut colonizationgut commensalhost responseimmune system responseimmunoresponseinsightinterestintestinal colonizationintestinal commensalliving systemmicrobial consortiamicrobial floramicrobiotamicrofloramultispecies consortianovelopportunistic pathogenparentpathobiontpathogenic funguspreventpreventingsocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatment
Description preview
Abstract (From Parent R01)
The fungus Candida albicans is a frequent commensal of the gastrointestinal (GI) tract but is also an
important cause of both mucosal and systemic disease. The GI population is particularly relevant to human
health as cells can translocate out of this niche to cause disseminated infections. C. albicans cells in the gut…
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