grant
Building predictive algorithms to identify resilience and resistance to Alzheimer's disease
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 1 Jun 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2025AD dementiaAD pathologyAD preventionAPOE e4APOE-ε4APOEε4AddressAfrican AmericanAfro AmericanAfroamericanAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer disease preventionAlzheimer preventionAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's disease pathologyAlzheimer's disease riskAlzheimer's pathologyAlzheimers DementiaAmyloidAmyloid SubstanceAreaAβ burdenBiometricsBiometryBiostatisticsBlackBlack raceBlood VesselsBrainBrain Nervous SystemCalibrationCell Communication and SignalingCell SignalingClassificationClinicalClinical TrialsClinical Trials DesignCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive ManifestationsCognitive SymptomsCognitive declineCognitive function abnormalDataDecision MakingDiagnosticDisturbance in cognitionEducationEducational aspectsEncephalonEpidemiologyEthnic GroupEthnic OriginEthnic PeopleEthnic PopulationEthnic individualEthnicityEthnicity PeopleEthnicity PopulationExhibitsFemaleGenderGeneticGoalsImpaired cognitionIndividualIntracellular Communication and SignalingKnowledgeLifeLong-term cohortLongitudinal cohortMT-bound tauMachine LearningMapsMeasuresMedicalModelingNeurobehavioral ManifestationsNeurobehavioral Signs and SymptomsNeuropsychologiesNeuropsychologyNon-HispanicNonhispanicNot Hispanic or LatinoPETPET ScanPET imagingPETSCANPETTPathologicPathologyPatientsPhenotypePopulationPositionPositioning AttributePositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrevention trialPrimary Senile Degenerative DementiaProteinsProtocolProtocols documentationPublishingRaceRacesRacial GroupRad.-PETResistanceResistance profileResistant profileRiskRisk EstimateRisk FactorsSample SizeSignal TransductionSignal Transduction SystemsSignalingStructureSymptomsSystematicsTheoretic ModelsTheoretical modelTherapeutic InterventionWhite Matter HyperintensityWomana-beta burdenabeta burdenalzheimer riskamyloid burdenapo E-4apo E4apo epsilon4apoE epsilon 4apoE-4apoE4apolipoprotein E epsilon 4apolipoprotein E-4apolipoprotein E4behavioral neurologybeta amyloid burdenbiological signal transductionburden of diseaseburden of illnessclinical decision-makingclinical practiceclinical trial recruitmentcognitive changecognitive dysfunctioncognitive losscognitive neurosciencecognitive performancecohortcomputer based predictiondata harmonizationdementia riskdemographicsdisease burdenepidemiologicepidemiologicalethnic subgroupethnicity groupflexibilityflexiblegray matterharmonized dataimprovedinnovateinnovationinnovativeintersectionalitiesintersectionalityintervention therapymachine based learningmalemenmicrotubule bound taumicrotubule-bound tauneural imagingneuro-imagingneurobehavioral symptomneuroimagingneurological imagingneuropsychologicold ageolder adultolder adulthoodpatient profilepositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographyprediction algorithmpredictive modelingpreservationprimary degenerative dementiaprofiles in patientsracialracial backgroundracial diversityracial originracial populationracial subgroupracially diverseresilienceresilientresistantresponserisk factor for dementiarisk for dementiascreeningscreeningssenile dementia of the Alzheimer typesexsocial culturesocio-culturalsocioculturalsubstantia griseatautau Proteinstau factortheoriesvascularvascular componentvascular factoryounger ageβ-amyloid burdenβamyloid burdenτ Proteins♀♂
Description preview
PROJECT SUMMARY
There are two observed phenomena that defy the traditional Alzheimer’s disease (AD) trajectory; those who
resist the accumulation of AD pathology (amyloid and/or tau) despite evidence of risk factors, and those who
present with AD pathology but remain resilient to cognitive decline. Classifying these individuals who will likely…
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