grant
Building a Systems Immunopeptidomics Framework to Challenge the Current T Cell Activation Paradigm
NIHUS FederalResearch GrantFY2025AI systemAdaptive Immune SystemAntitumor ResponseArtificial IntelligenceAutoimmune DiseasesBody TissuesCAR T cell therapyCAR T cellsCAR T therapyCAR modified T cellsCAR-TCAR-TsCancersCell Communication and SignalingCell SignalingCell surfaceClinicalCommunicable DiseasesComplexComputer ReasoningDevelopmentDiathesisDisease ResistanceDisease susceptibilityFoundationsHumanImmune responseImmune systemImmunityImmunomodulationIn VitroInfectious DiseasesInfectious DisorderIntracellular Communication and SignalingLeadMachine IntelligenceMachine LearningMalignant NeoplasmsMalignant TumorMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMath ModelsMedicalMedicineMethodsModelingModern ManMonitorNerve DegenerationNeuron DegenerationOrganismOutcomeParticipantPb elementPeptide FragmentsPeptidesPlayResearchRoboticsRoleSafetySignal TransductionSignal Transduction SystemsSignalingSystemT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell immune therapyT cell immunotherapyT cell responseT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cells for CART cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-Cell ActivationT-CellsT-LymphocyteT-cell therapeuticsT-cell transfer therapyTechniquesTechnologyTestingTherapeuticThinkingTissuesTolerogenVaccine Designacquired immune systemactivate T cellsadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyaging associated diseaseaging associated disordersaging related diseaseaging related disordersanti-cancer immunotherapyanti-tumor responseanticancer immunotherapyautoimmune conditionautoimmune disorderautoimmunity diseasebiological signal transductioncancer immunotherapycell typechimeric antigen T cell receptorchimeric antigen receptor (CAR) T cell therapychimeric antigen receptor (CAR) T cellschimeric antigen receptor Tchimeric antigen receptor T cell therapychimeric antigen receptor T cellschimeric antigen receptor T therapychimeric antigen receptor fusion protein T-cellschimeric antigen receptor modified T cellsdevelopmentaldisease associated with agingdisease of agingdisorder of agingdisorders associated with agingdisorders related to agingdynamic systemdynamical systemfightinggene manipulationgenetic manipulationgenetically manipulategenetically perturbheavy metal Pbheavy metal leadhost responseimmune modulationimmune regulationimmune system responseimmune-based cancer therapiesimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimmunotherapy for cancerimmunotherapy of cancerimprovedin vivoinnovateinnovationinnovativeinsightinterdisciplinary approachliability to diseaseliving systemmachine based learningmalignancymathematic modelmathematical modelmathematical modelingmouse modelmultidisciplinary approachmurine modelneoplasm/cancerneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generationnext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachresistance to diseaseresistant diseaseresistant to diseaseresponsesocial rolestemtherapeutic T-cell platformthoughtsthymus derived lymphocyte
Description preview
PROJECT SUMMARY
The adaptive immune system, a cornerstone of vertebrate immunity for over 450 million years, relies heavily on
T cells to monitor and respond to peptide fragments on cell surfaces. Traditionally, T cells have been thought to
activate only in response to foreign or abnormal peptides (nonself), while viewing the myriad of normal…
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