grant
Branched chain amino acids in heart failure
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Apr 2020Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2025AddressAffectAortaAutoregulationBP reductionBlood PlasmaBlood VesselsBlood flowBody TissuesBranched-Chain Amino AcidsCancersCardiacCardiac Muscle CellsCardiac MyocytesCardiac arteryCardiac infarctionCardiocyteCatabolismCause of DeathClinical EvaluationClinical TestingCoronary arteryDataDeath RateDevelopmentEndogenous Nitrate VasodilatorEndothelial CellsEndothelium-Derived Nitric OxideFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2FundingGeneticHeartHeart Muscle CellsHeart arteryHeart failureHeart myocyteHomeostasisHospital AdmissionHospitalizationHumanIP3RIP3R1ITPR1ITPR1 geneImageInositol 1,4,5-Triphosphate Receptor Type 1Insp3r1Intermediary MetabolismInvoluntary MuscleIsoleucineKidney FailureKidney InsufficiencyL-ValineLeiomyocyteLeucineMalignant NeoplasmsMalignant TumorMechanistic Target of RapamycinMediatingMesenteric ArteriesMetabolic ProcessesMetabolismMiceMice MammalsModelingModern ManMononitrogen MonoxideMurineMusMyocardialMyocardial InfarctMyocardial InfarctionMyographyNitric OxideNitrogenNitrogen MonoxideNitrogen ProtoxideNutrientPETPET ScanPET imagingPETSCANPETTPathologyPathway interactionsPatientsPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhysiological HomeostasisPlasmaPlasma SerumPlayPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyProductionRAFT1Rad.-PETRelaxationRenal FailureRenal InsufficiencyReticuloendothelial System, Serum, PlasmaRoleSecondary toSeriesSmooth MuscleSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellTestingTissuesValineVasodilatationVasodilationVasorelaxationadverse consequenceadverse outcomeaorta constrictionblood pressure reductionbranched amino acidscardiac failurecardiac imagingcardiac infarctcardiac scanningcardiac vasculaturecardiomyocytecardioprotectantcardioprotectioncardioprotectivecell typeclinical testcoronary attackcoronary infarctcoronary infarctiondevelopmentalendothelial cell derived relaxing factorgain of functionheart attackheart imagingheart infarctheart infarctionheart scanninghuman subjectimagingimprovedinhibitorinterestloss of functionlower BPlower blood pressurelowers blood pressuremTORmalignancymammalian target of rapamycinmodel organismmortality ratemortality ratiomouse modelmurine modelneoplasm/cancernew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoxidationpathwaypharmaceuticalpharmacologicphase 1 trialphase I trialpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypre-clinical studypreclinical studyreduce BPreduce blood pressurereduction in BPreduction in blood pressureresearch clinical testingsocial rolevascularvascular constrictionvasoconstrictionvolunteer
Description preview
SUMMARY
Heart failure (HF) is a leading cause of death worldwide, and the leading cause of hospital admissions in patients
over 65 in the US. Novel therapies, addressing novel pathways, are direly needed. The role of metabolism in
cardiac pathology has long been of interest. We have focused for several years on the role of branched chain
amino…
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