grant
Brain fluid clearance and misfolded protein dynamics following traumatic brain injury
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 30 Sept 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AD dementiaAbeta clearanceAbscissionAccelerationAccident and Emergency departmentAcuteAffectAgingAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's disease riskAlzheimers DementiaAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid ProteinsAmyloid beta-ProteinAmyloid βAmyloid β clearanceAmyloid β-PeptideAmyloid β-ProteinAnimal DiseasesAnimal ModelAnimal Models and Related StudiesAnimalsAquaporinsAβAβ clearanceBiological MarkersBloodBlood Reticuloendothelial SystemBlood VesselsBrainBrain Nervous SystemBrain TraumaCNS lymphatic systemCSF clearanceCause of DeathCerebrospinal FluidClinical assessmentsCognitionCognitiveComplexDataDegenerative Neurologic DisordersDepositDepositionDevelopmentDiffusionDisease ProgressionDrugsDysfunctionEmergency DepartmentEmergency roomEncephalonExcisionExtirpationFailureFunctional MRIFunctional Magnetic Resonance ImagingFunctional disorderFutureGeneral Prognostic FactorGoalsHourHumanImpairmentInflammationInjuryIntercellular FluidInterstitial FluidsInterventionLesionLiquid substanceLongitudinal StudiesMR ImagingMR TomographyMRIMRIsMT-bound tauMTBIMagnetic Resonance ImagingMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicationMetabolic Clearance RateMethodsModalityModelingModern ManMonitorNMR ImagingNMR TomographyNerve DegenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNuclear Magnetic Resonance ImagingOutcomePETPET ScanPET imagingPETSCANPETTPathologicPersonsPharmaceutical PreparationsPhasePhysiopathologyPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary Senile Degenerative DementiaProcessPrognostic FactorPrognostic/Survival FactorProtein DynamicsProteinsPublishingRad.-PETRecoveryRemovalReportingResearchRiskRisk FactorsSleepSleep disturbancesSurgical RemovalSymptomsSystemTBI recoveryTechniquesTimeToxinTraumatic Brain InjuryTraumatic Brain Injury recoveryVentricularWater Channel ProteinsZeugmatographya beta peptidea-beta peptide clearanceaberrant folded proteinaberrant folded proteinsaberrant sleepabetaabeta accumulationabeta aggregationabeta depositionabeta peptide clearanceabnormal brain functionabnormal folded proteinabnormal folded proteinsalzheimer riskamyloid betaamyloid beta accumulationamyloid beta aggregationamyloid beta clearanceamyloid beta depositionamyloid beta peptide clearanceamyloid β accumulationamyloid β aggregationamyloid β depositionamyloid-b proteinaβ accumulationaβ aggregationaβ depositionbeta amyloid fibrilbio-markersbiologic markerbiomarkerbrain dysfunctionbrain impairmentbrain lymph systembrain lymphatic systemcerebral spinal fluidcerebrospinal fluid clearanceclearance ratecompare to controlcomparison controlcritical perioddegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningdevelopmentaldiffuseddiffusesdiffusingdiffusionsdisabilitydisrupted sleepdisturbed sleepdrug/agentdysfunctional brainfMRIfluidfluid flowglia lymphatic circuitglia-lymphatic systemglial lymphatic systemglialymphatic circuitglialymphatic networkglialymphatic pathwayglialymphatic systemglymphatic circulationglymphatic clearanceglymphatic clearance pathwayglymphatic flowglymphatic pathwayglymphatic systemglymphatic-lymphatic systemglymphaticshuman modelimpaired sleepinjuriesinsightirregular sleepliquidlong-term studylongitudinal outcome studiesmicrotubule bound taumicrotubule-bound taumild TBImild brain traumamild traumatic brain injurymisfolded proteinmisfolded proteinsmodel of animalmodel of humanmulti-modalitymultimodalityneural degenerationneural imagingneuro-imagingneurodegenerationneurodegenerativeneurodegenerative illnessneuroimagingneurological degenerationneurological imagingneuronal degenerationnovelparavascular flowparavascular systempathophysiologypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypreventpreventingprimary degenerative dementiaprimary outcomeprospectiveproteotoxic proteinproteotoxinradiolabelradiolabelsradiotracerrecovery after TBIrecovery after traumatic brain injuryrecruitresectionsecondary outcomesenile dementia of the Alzheimer typesleep disruptionsleep dysregulationsleep/wake disruptionsleep/wake disturbancesoluble amyloid precursor proteinsolutespinal fluidstandard measuretargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttautau Proteinstau factortherapeutic targettraumatic brain damagevascularventricular systemwastingwater channelwater transporterτ Proteins
Description preview
PROJECT SUMMARY/ABSTRACT
Traumatic Brain Injury (TBI) is a leading cause of death and disability and a risk factor for later development of
Alzheimer's Disease (AD.) This project focuses on brain cerebrospinal/interstitial fluid systems essential for
clearing the brain of waste and toxins, including the glymphatic system, as important to the…
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