grant
Botanical derived progestins and their impact on women's health
Organization UNIVERSITY OF ILLINOIS AT CHICAGOLocation Chicago, UNITED STATESPosted 1 May 2016Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2026AddressAgonistAlternative TherapiesAlternative interventionAndrogen ReceptorAnimal ModelAnimal Models and Related StudiesAreaAssayAwarenessBasic ResearchBasic ScienceBenignBindingBioassayBiologicalBiological AssayBotanical dietary supplementsBotanicalsCell BodyCell Communication and SignalingCell SignalingCellsCellular AssayChemicalsChromatographyCommon Rat StrainsComputer ModelsComputerized ModelsConsumptionCorlutinaCorluviteCorpus Luteum HormoneCyclogestDataDelta4-pregnene-3,20-dioneDietary supplementation with botanicalsDiseaseDisorderDogwoodElementsEndocrine Gland SecretionEnsureEstrogen ReceptorsFamilyFemale HealthFibroidFibroid NeoplasmFibroid TumorFibromyomaGene TranscriptionGeneralized GrowthGenetic TranscriptionGestagenic AgentsGestagensGestironGestoneGlucocorticoid ReceptorGoalsGrowthGynecologicHealthHealth BenefitHerbal dietary supplementHerbal supplementHormonesIntracellular Communication and SignalingKnowledgeLeiomyomatous NeoplasmLeiomyomatous TumorLigandsLipo-LutinLuciferase ImmunologicLuciferasesLuteohormoneLutocyclinLutocylin MLutogylLutromoneMalignant Neoplasm of the UterusMalignant Tumor of the UterusMalignant Uterine NeoplasmMalignant Uterine TumorMarketingMeasuresMediatingMicrofluidicsModelingMolecular InteractionMonitorNCCAMNCCIHNational Center for Complementary and Integrative HealthNational Center for Complementary and Integrative MedicineNatural ProductsNuclear ReceptorsPlantsPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPre-Clinical ModelPreclinical ModelsPregn-4-ene-3,20-dionePregnenedionePremature BirthPrematurely deliveringPreterm BirthPreventionProgestagenic AgentsProgestasertProgestational AgentsProgestational CompoundsProgestational Hormone AnaloguesProgestational HormonesProgesteroneProgesterone AgentsProgesterone ReceptorsProgestin AnaloguesProgestin ReceptorsProgestinsProgestogelProgestogensProgestolProgestonProlidonProlutonPropertyProtein ModificationPublic HealthRNA ExpressionRNA SeqRNA sequencingRNAseqRatRats MammalsRattusReceptor ProteinReceptor SignalingRed CloverRepressionRiskSafetySignal TransductionSignal Transduction SystemsSignalingStructureSyngesteroneSynthetic Progestational HormonesSynthetic ProgestinsSynthetic ProgestogensTechnologyTestingTherapeutic ProgesteroneTherapeutic ProgestinTherapeutic UsesTissue GrowthTranscriptionTrifolium pratenseUterine BleedingUterine CancerUterine DiseasesUterine DisorderUterine hemorrhageUterus CancerUtrogestanVitexWomanWomen's HealthYuccaantagonismantagonistbiologicbiological signal transductionbotanical supplementbotanical supplementationcell assaychemo-dietarychemodietarycomputational modelingcomputational modelscomputer based modelscomputerized modelingcostcost effectivediet supplementdietarydietary chemopreventiondietary supplementsendometriosisestrogen receptor proteinestrophileestrophilinexperimentexperimental researchexperimental studyexperimentsgenome scalegenome-widegenomewideimprovedmembermodel of animalnaturally occurring productneglectnutritional supplementontogenyorgan chiporgan on a chiporgan on chippre-clinicalpreclinicalpremature childbirthpremature deliverypreterm deliverypreventpreventingreceptorreceptor bindingreceptor boundtranscriptome sequencingtranscriptomic sequencinguterus bleedinguterus disorderuterus hyperplasiaµfluidic
Description preview
Botanical dietary supplement use has skyrocketed over the last ten years. One significant portion of this market
is herbal supplements targeted toward women, who commonly use them to treat their gynecological ailments,
not only for their cost-effective advantage or affordability, but also for their health benefits. Progesterone is an
endogenous…
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