grant
Body composition and adiposity-associated thromboinflammation in colorectal cancer prognosis
Organization H. LEE MOFFITT CANCER CTR & RES INSTLocation TAMPA, UNITED STATESPosted 1 May 2024Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026(TNF)-α3-10C3-D3-Dimensional3DAI AugmentedAI assistedAI drivenAI enhancedAI integratedAI poweredAMCF-IAbdomenAbdominal obesityAcetylsalicylic AcidAddressAdipose tissueAgeAndroid fat distributionArtificial Intelligence enhancedAspirinAugmented by AIAugmented by the AIAugmented with AIAugmented with the AIAutomobile DrivingB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBMIBMI percentileBMI z-scoreBSF-2BSF2BiologicalBiological MarkersBiologyBloodBlood PlasmaBlood Platelet CountBlood Platelet NumberBlood PlateletsBlood Reticuloendothelial SystemBody CompositionBody MeasuresBody fatBody mass indexBody measure procedureCAT scanCCL5CD62P AntigensCT X RayCT XrayCT imagingCT scanCXCL8CachectinCancer BiologyCancer PrognosisCancersCentral obesityCentripetal obesityCharacteristicsChemokine (C-C Motif) Ligand 5ClinicalClinical DataClinical stratificationColonColon NeoplasmsColon TumorColonic MassColonic NeoplasmsColonic TumorColorectal CancerComputed TomographyComputer softwareD17S136EDataDiagnosisDiagnosticDifferences between sexesDiffers between sexesDimensionsDrug or chemical Tissue DistributionFatsFatty TissueFatty acid glycerol estersFundingGCP1GMP-140General RadiologyHPGFHepatocyte-Stimulating FactorHybridoma Growth FactorIFN-beta 2IFNB2IL-6IL-8IL6 ProteinIL8IL8 geneImageImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIndividualInflammationInterdisciplinary ResearchInterdisciplinary StudyInterleukin-6InterventionInvestigationK60KnowledgeLECAM-3LinkLymphatic cellLymphocyteLymphocyticMGC17164MGI-2Macrophage-Derived TNFMalignant NeoplasmsMalignant TumorMarrow plateletMeasurementMeasuresMediatingMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMethodologyMethodsMonocyte-Derived TNFMorbidity - disease rateMultidisciplinary CollaborationMultidisciplinary ResearchMyeloid Differentiation-Inducing ProteinNeoplasm MetastasisObesityObesity EpidemicOutcomeP-SelectinParticipantPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPlasmaPlasma SerumPlasmacytoma Growth FactorPlatelet ActivationPlatelet CountPlatelet Count measurementPlatelet NumberPlatelet alpha-Granule Membrane ProteinPlateletsPlayPopulationQuetelet indexRANTESRadiologyRadiology SpecialtyRectumRecurrenceRecurrentReportingResearch ResourcesResourcesReticuloendothelial System, Serum, PlasmaRiskRoleSCYA5SCYB8SIS deltaSIS-deltaSISdSamplingScanningScienceSecondary NeoplasmSecondary TumorSex DifferencesSexual differencesSiteSkeletal MuscleSliceSmall Inducible Cytokine A5SoftwareSurvival RateT-Cell RANTES ProteinT-Cell Specific Protein p288TCP228TNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTSG-1TestingThrombocytesTimeTissue DistributionTomodensitometryTreatment outcomeTreatment-related toxicityTruncal obesityTumor Necrosis FactorTumor Necrosis Factor-alphaTumor TissueUrineVEGFVEGFsVascular Endothelial Growth FactorsVisceralVoluntary MuscleX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyXray CAT scanXray Computed TomographyXray computerized tomographyadiposeadiposityage stratificationagesangiogenesisartificial intelligence assistedartificial intelligence augmentedartificial intelligence drivenartificial intelligence integratedartificial intelligence poweredb-ENAPbio-markersbiologicbiologic markerbiomarkercancer metastasiscancer microenvironmentcancer progressioncancer typecatscanclinical applicabilityclinical applicationclinical predictorsclinical relevanceclinically relevantcolon cancer patientscolon neoplasiacolorectal cancer patientscolorectal cancer progressioncolorectal cancer therapycolorectal cancer treatmentcomputed axial tomographycomputer tomographycomputerized axial tomographycomputerized tomographycorpulencecost effectivecustomized therapycustomized treatmentdrivingenhanced with AIenhanced with Artificial Intelligenceimagingimaging Segmentationindividualized medicineindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentinnovateinnovationinnovativeinsightinterferon beta 2lymph cellmalignancymorbidity ratemuscle bulkmuscle formmuscle massneoplasm progressionneoplasm/cancerneoplastic progressionnew approachesnon-contrast CTnoncontrast CTnoncontrast computed tomographynovelnovel approachesnovel strategiesnovel strategyparticipant enrollmentpathwaypatient enrollmentpatient oriented outcomespatient populationpatient specific therapiespatient specific treatmentpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpharmacologicpoint of careprognosticsarcopeniasarcopenicsexsex based differencessex-dependent differencessex-related differencessex-specific differencesskeletal muscle atrophyskeletal muscle breakdownskeletal muscle lossskeletal muscle protein lossskeletal muscle wastingsocial rolespecific biomarkerssurvival outcometailored medical treatmenttailored therapytailored treatmenttherapeutic toxicitytherapy associated toxicitytherapy related toxicitytherapy toxicitythree dimensionalthromboinflammationthromboinflammatorytreatment strategytreatment toxicitytreatment-associated toxicitytumortumor cell metastasistumor microenvironmenttumor progressionunique treatmenturinaryvisceral obesitywhite adipose tissueyellow adipose tissue
Description preview
SUMMARY
Obesity increases the risk of numerous cancers including colorectal cancer (CRC). With the growing global epidemic of obesity, a greater understanding of the obesity cancer-link, including its underlying biology and its adverse influence on patient outcomes is critically needed. Our ability to treat patients optimally has been hampered, in…
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