grant
BLRD Research Career Scientist Award Application
Organization VA NEW JERSEY HEALTH CARE SYSTEMLocation EAST ORANGE, UNITED STATESPosted 1 Apr 2023Deadline 31 Mar 2028
VANIHUS FederalResearch GrantFY20252-Amino-6-trifluoromethoxybenzothiazoleAAASALS therapyALS treatmentAcademiaAmerican Association for the Advancement of ScienceAnimal ModelAnimal Models and Related StudiesAppointmentAreaAutomobile DrivingAwardBasic ResearchBasic ScienceBioavailabilityBiologic ModelsBiological AvailabilityBiological ModelsBiologyBrainBrain CancerBrain MetastasisBrain Nervous SystemBreast CancerCINJCNS Nervous SystemCTEPCancer Institute of New JerseyCancer PatientCancer Therapy Evaluation ProgramCancersCausalityCell Communication and SignalingCell SignalingCell surfaceCentral Nervous SystemCharacteristicsChemicalsClinicClinicalClinical TreatmentClinical TrialsCollaborationsCommunitiesCytochrome P-450Cytochrome P-450 Enzyme SystemCytochrome P450Cytochrome P450 Family GeneDNA AlterationDNA Sequence AlterationDevelopmentDisciplineDiseaseDisorderDrug PrecursorsDrug TherapyEctopic ExpressionEncephalonEpithelial CellsEtiologyExperimental ModelsFDA approvedFellowshipGPRC1AGRM1GRM1 geneGRM1AGenetic AlterationGlial Cell TumorsGlial NeoplasmGlial TumorGliomaGlutamatesGoalsGrantHalf-LifeHealthHumanIn VitroIndustry CollaborationIndustry CollaboratorsIntermediary MetabolismIntracellular Communication and SignalingInvestigationInvestigatorsJointsKidney CancerKidney CarcinomaKnowledgeL-GlutamateLab FindingsLaboratoriesLaboratory FindingLearningLegal patentLesionLigandsLongitudinal StudiesLungLung Respiratory SystemMGLUR1MGLUR1AMalignant Breast NeoplasmMalignant MelanomaMalignant NeoplasmsMalignant TumorMalignant Tumor of the BrainMalignant neoplasm of brainMedical centerMelanomaMelanoma patientMemoryMetabolic ProcessesMetabolismMetabotropic 1 Glutamate ReceptorMetabotropic Glutamate ReceptorsMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic Neoplasm to the BrainMetastatic TumorMetastatic Tumor to the BrainMetastatic malignant neoplasm to brainMiceMice MammalsModel SystemModelingModern ManModificationMulti-Institutional Clinical TrialMulti-center clinical trialMulti-site clinical trialMulticenter clinical trialMultisite clinical trialMurineMusNCI OrganizationNational Cancer InstituteNeoplasm MetastasisNerve CellsNerve UnitNeural CellNeuraxisNeurocyteNeuroglial NeoplasmNeuroglial TumorNeuronsOncogenicOrangesOrganP450PatentsPatient RecruitmentsPatientsPeer ReviewPennsylvaniaPharmacological TreatmentPharmacotherapyPharmacy SchoolsPhasePhysiciansPhysiologic AvailabilityPostdocPostdoctoral FellowPro-DrugsProbabilityProdrugsPrognostic MarkerPropertyPublicationsR-Series Research ProjectsR01 MechanismR01 ProgramReceptor ProteinRenal CancerRenal CarcinomaResearchResearch AssociateResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearch SupportResearchersRewardsRiluzoleRoleSBIRScientific PublicationScientistSecondary NeoplasmSecondary TumorSecureSequence AlterationSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteSmall Business Innovation ResearchSmall Business Innovation Research GrantSystemTechnologyTestingToxic effectToxicitiesTransgenic MiceTranslatingTranslational ResearchTranslational ScienceTranslationsTrusteesUniversitiesWorkamyotrophic lateral sclerosis therapyamyotrophic lateral sclerosis treatmentanti-cancer researchbiological signal transductionbiomarker identificationbrain micrometastasiscancer metastasiscancer researchcareercausationcell transformationclinical interventionclinical therapydevelopmentaldisease causationdistinguished professordrivingdrug discoverydrug interventiondrug treatmentexperimentexperimental researchexperimental studyexperimentsgenomic alterationglial-derived tumorglutamate signalingglutamatergicglutamatergic dendrodendritic synapsesglutamatergic signalinghuman modelidentification of biomarkersidentification of new biomarkersimprovedin vivoinnovateinnovationinnovativeinter-individual variabilityinter-individual variationinterestlong-term studylongitudinal outcome studiesmGlu1malignancymalignant breast tumormarker identificationmelanocytemelanomagenesismetabotropic glutamate receptor type 1model of animalmodel of humanmolecular pathologymouse modelmurine modelneoplasm/cancerneuroglia neoplasmneuroglia tumorneuronalparticipant recruitmentpatients suffering from melanomapatients with melanomapharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspost-docpost-doctoralpost-doctoral traineepre-clinicalpreclinicalpreventpreventingprognostic biomarkerprognostic indicatorprogramsreceptorresearch associatesscreeningscreeningssocial roletherapeutically effectivetooltransformed cellstranslationtranslation researchtranslational applicationstranslational investigationtranslational modeltrial regimentrial treatmenttumortumor cell metastasis
Description preview
Mouse models reflecting human cancers are important tools towards the translation of basic science
discoveries to clinical therapies. However, rapidly evolving technologies within the last few years require
further refining current approaches that enable models to be more suitable in robust translational
applications to provide consistent…
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