grant
BLRD Research Career Scientist Award Application
Organization VETERANS AFFAIRS MED CTR SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Oct 2019Deadline 30 Sept 2029
VANIHUS FederalResearch GrantFY20261-Alpha-Hydroxylase25-Hydroxyvitamin D3-1-Alpha-Hydroxylase4-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acidAD dementiaAblationAbscissionAcquired brain injuryAcuteAcute Brain InjuriesAdoptedAgingAgonistAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's precursor proteinAlzheimers DementiaAmentiaAminalonAminaloneAmyloid A4 Protein PrecursorAmyloid Protein PrecursorAmyloid beta-Protein PrecursorAmyloid β-Protein PrecursorAnabolismAnimal ModelAnimal Models and Related StudiesAnimalsAntibodiesApplications GrantsAutoregulationAwardBeta-R1BindingBiologyBiomechanicsBody TissuesBrainBrain DiseasesBrain DisordersBrain InjuriesBrain Nervous SystemBrain TraumaButanoic AcidsButyric AcidsCASR ProteinCXCL11CXCL11 geneCYP27B1CYP27B1 geneCa-Sensing ReceptorCa2+-Sensing ReceptorCalcium ReceptorsCalcium-Sensing Receptor ProteinCalcium-Sensing ReceptorsCancersCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessChemokine (C-X-C Motif) Ligand 11ChondrocytesChronicClinicalClinical ResearchClinical StudyClinical TrialsCombined Modality TherapyCommunitiesCytochrome P450, Subfamily XXVIIB, Polypeptide 1DNA Molecular BiologyDataDementiaDevelopmentDiseaseDisorderEOADEarly Onset Alzheimer DiseaseEarly Onset Familial Alzheimer's DiseaseEconomic BurdenEncephalonEncephalon DiseasesEndocrine TherapyExcisionExtirpationExtracellular Calcium-Ion Sensing ReceptorFDA approvedFDA licensed drugsFDA-approved agentsFDA-approved drugFDA-approved medicationsFDA-approved pharmaceuticalsFDA-approved therapeutic agentFamilyFood and Drug Administration approved drugFood and Drug Administration approved medicationsFood and Drug Administration approved pharmaceuticalsForteoFractureFracture HealingFundingGABAGenesGrant ProposalsH174Health Care SystemsHeart VascularHeterodimerizationHeterozygoteHomeostasisHormonalHormonal TherapyHormone secretionHypercalcemiaHyperparathyroidismI-TACIGF1IGF1 geneIGF1RIGF1R geneIGFIIP-9IP9Immune systemIn VitroInjectionsInsulin-Like Growth Factor 1 Receptor GeneInterdisciplinary ResearchInterdisciplinary StudyInterferon-Gamma-Inducible Protein-9Interferon-Inducible T-Cell Alpha ChemoattractantIntracellular Communication and SignalingIntracranial CNS DisordersIntracranial Central Nervous System DisordersInvoluntary MuscleIschemiaIschemic Brain InjuryKO miceKidneyKidney Urinary SystemKnock-out MiceKnockout MiceLigandsLoxP-flanked alleleLungLung Respiratory SystemMacromolecular StructureMalignant NeoplasmsMalignant TumorMammary glandMediatingMiceMice MammalsMineralsMolecularMolecular BiologyMolecular InteractionMolecular StructureMultidisciplinary CollaborationMultidisciplinary ResearchMultimodal TherapyMultimodal TreatmentMurineMusNational Institutes of HealthNatureNerve CellsNerve DegenerationNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeurocyteNeuron DegenerationNeuronal TransmissionNeuronsNeurosciencesNull MouseO elementO2 elementOklahomaOsteoblastsOsteoporosisOxygenP450C1-AlphaPTH geneParathyrinParathyroidParathyroid Calcium-Sensing ReceptorParathyroid Head and NeckParathyroid HormoneParathyroid glandPathogenesisPathogenicityPathologicPathway interactionsPatientsPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhenotypePhysiologicPhysiologicalPhysiological HomeostasisPilot ProjectsPopulationPost-MenopausePost-menopausal PeriodPostmenopausal PeriodPostmenopausePrimary Senile Degenerative DementiaProgram ReviewsPropertyProteinsQOLQuality of lifeR-Series Research ProjectsR01 MechanismR01 ProgramReagentReceptor ActivationReceptor ProteinReceptor SignalingRegimenRegulationRemovalResearchResearch ActivityResearch GrantsResearch Project GrantsResearch ProjectsRoleSCYB11SCYB9BScientistServicesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSiteSkeletal DevelopmentSkeletal boneSkinSmall Inducible Cytokine B11Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 11Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 9BSmooth MuscleSubcellular ProcessSurgical RemovalSystemTechnologyTechnology TransferTeriparatideTestingTherapeutic HormoneTimeTissuesTranslational ResearchTranslational ScienceTraumatic Brain InjuryUnited States National Institutes of HealthUniversitiesUpregulationVeteransafter menopauseaging associated diseaseaging associated disordersaging related diseaseaging related disordersamyloid precursor proteinanti-cancer researchaxon signalingaxon-glial signalingaxonal signalingb-R1biological signal transductionbiomechanicalbiosynthesisbonebone fracturebone fracture healingbone fracture repairbrain damagebrain-injuredcancer researchcareercirculatory systemcombination therapycombined modality treatmentcombined treatmentdevelopmentaldisease associated with agingdisease of agingdisorder of agingdisorders associated with agingdisorders related to agingdruggable targetearly onset ADearly onset Alzheimer'sendocrine treatmentexperimentexperimental researchexperimental studyexperimentsextracellularfloxedfloxed allelefollowing menopausefracture repairgamma-Aminobutyric Acidgastrointestinalgene manipulationgenetic approachgenetic manipulationgenetic strategygenetically manipulategenetically perturbglia signalingglial signalinghPTH (1-34)heterozygosityhormonal secretionhormonal treatmenthormone therapyhormone treatmentin vivoindividuals with osteoporosisischemic brain damagemalemalignancymodel of animalmouse modelmulti-modal therapymulti-modal treatmentmurine modelneoplasm/cancernerve cell deathnerve cell lossnerve signalingneural degenerationneural signalingneurodegenerationneurodegenerativeneurological degenerationneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal degenerationneuronal lossneuronal signalingneurotransmissionnew combination therapiesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapynutrient deprivationnutritional deprivationosteoporosis individualsosteoporosis patientsosteoporosis peopleosteoporosis populationosteoporotic individualosteoporotic patientsosteoporotic populationoverexpressoverexpressionparathormonepast menopausepathwaypatients with osteoporosispeople with osteoporosispharmaceuticalpharmacologicpilot studypopulation with osteoporosispost-menopausalpostmenopausalpostmenopausal statuspostnatalpre-clinicalpreclinicalprenatalpreventpreventingprimary degenerative dementiaprogramspulmonaryreceptorreceptor expressionrenalrepurposingresectionsenile dementia of the Alzheimer typeside effectskeletalskeletal diseaseskeletal disordersocial rolesocio-economicsocio-economicallysocioeconomicallysocioeconomicssystems researchtranslation researchtranslational investigationtraumatic brain damageunbornγ-Aminobutyric Acid♂
Description preview
My research investigates signal transduction, molecular structures, and pathophysiological actions of the
extracellular calcium-sensing receptor (CaSR) and its associated signaling molecules in the regulation of
mineral and skeletal homeostasis and more recently in the induction of brain diseases. During the current
research Career Scientist (RCS)…
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