grant
BLRD Research Career Scientist Award Application
Organization HARRY S. TRUMAN MEMORIAL VA HOSPITALLocation COLUMBIA, UNITED STATESPosted 1 Oct 2017Deadline 30 Sept 2029
VANIHUS FederalResearch GrantFY2025AP-1AP-1 Enhancer-Binding ProteinAP1AP1 proteinASCVDActivator Protein-1AffectAldosteroneAngIIAngiotensin IIAntiinflammatory EffectAtherosclerosisAtherosclerotic Cardiovascular DiseaseAwardB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2Basal Transcription FactorBasal transcription factor genesBindingBiopsyBody TissuesC-jun Amino-Terminal KinaseC-jun Kinase-1C-jun N-Terminal Kinase 1CD40 Receptor-Associated Factor 1CD40bp ProteinCRAF1 ProteinCSAID-Binding Protein 1CSAID-Binding Protein 2CSBP2CTLA-8CTLA-8 GeneCTLA8CTLA8 GeneCardiacCardiac DiseasesCardiac DisordersCardiac Muscle CellsCardiac MyocytesCardiocyteCardiovascular DiseasesCausalityCell Communication and SignalingCell DeathCell SignalingCharacteristicsChemotactic CytokinesChronic DiseaseChronic IllnessCollaborationsCollagenColoradoComplement Factor HCritical PathsCritical PathwaysCytokine-Suppressive Antiinflammatory Drug-Binding Protein 1Cytokine-Suppressive Antiinflammatory Drug-Binding protein 2CytoplasmCytotoxic T-Lymphocyte-Associated Antigen 8Cytotoxic T-Lymphocyte-Associated Antigen 8 GeneCytotoxic T-Lymphocyte-Associated Serine Esterase 8Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 GeneDataDepositDepositionDevelopmentDiabetes MellitusDisclosureDisease ProgressionDockingDysfunctionEligibilityEligibility DeterminationEndothelial CellsEnhancer-Binding Protein AP1EtiologyExtracellular Signal-Regulated Kinase GeneFactor HFamily memberFibrillar CollagenFibroblastsFibrosis in the heartFibrosis in the myocardiumFibrosis within the heartFibrosis within the myocardiumFibrotic myocardiumFloridaFunctional disorderFundingGP130GPI Membrane AnchorsGene DeletionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGlycoinositol Phospholipid Membrane AnchorGlycosyl-Phosphatidylinositol Membrane Protein AnchorsGlycosylphosphatidylinositol AnchorsGoalsHPGFHealth CareHealth Care SystemsHeartHeart DiseasesHeart HypertrophyHeart Muscle CellsHeart failureHeart myocyteHepatocyte-Stimulating FactorHomolog of Drosophila TOLLHomologous Chemotactic CytokinesHumanHybridoma Growth FactorHypertensionHypertrophyIFN-Gamma-Inducing Factor GeneIFN-beta 2IFN-gamma-Inducing FactorIFNB2IGIFIGIF GeneIL-1IL-1 GammaIL-1 Gamma GeneIL-17IL-17 GeneIL-17AIL-17A GeneIL-18IL-18 GeneIL-1gIL-1g GeneIL-6IL1IL17IL17 ProteinIL17 geneIL17AIL17A GeneIL18IL18 ProteinIL18 geneIL1F4IL1F4 GeneIL6 ProteinIL6STIL6ST geneImmunoglobulin Enhancer-Binding ProteinIn VitroInflammationInflammatoryInformation DisclosureInjuryIntercrinesInterferon-Gamma-Inducing Factor GeneInterferon-gamma-Inducing FactorInterleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) GeneInterleukin 17 PrecursorInterleukin 17 Precursor GeneInterleukin 18 (Interferon-Gamma-Inducing Factor)Interleukin 18 (Interferon-Gamma-Inducing Factor) GeneInterleukin 18 ProproteinInterleukin 18 Proprotein GeneInterleukin 6 Signal TransducerInterleukin IInterleukin-1Interleukin-1 GammaInterleukin-1 Gamma GeneInterleukin-17Interleukin-18Interleukin-18 PrecursorInterleukin-18 Precursor GeneInterleukin-6InterleukinsInterventionIntervention StudiesIntracellular Communication and SignalingInvestigatorsIschemiaIschemic HeartIschemic Heart DiseaseIschemic myocardiumIsoprenalineIsopropyl NoradrenalineIsopropylarterenolIsopropylnoradrenalineIsopropylnorepinephrineIsoproterenolIsuprelJN KinaseJNKJNK Mitogen-Activated Protein KinasesJNK1JNK1 KinaseJNK1 proteinJNK1A2JNK21B1/2KI miceKnock-in MouseKnock-outKnockoutLAP-1 ProteinLymphocyte-Stimulating HormoneMAP Kinase 8MAP Kinase 8 GeneMAP Kinase GeneMAPKMAPK14MAPK14 Mitogen-Activated Protein KinaseMAPK14 geneMAPK8MAPK8 Mitogen-Activated Protein KinaseMAPK8 geneMGC12320MGC12320 GeneMGI-2MMP InhibitorMMPsMacrophage Cell FactorMatrix Metalloproteinase InhibitorMatrix MetalloproteinasesMediatingMediatorMembraneMessenger RNAMicrobubblesMissionMitogen-Activated Protein Kinase 14Mitogen-Activated Protein Kinase 8Mitogen-Activated Protein Kinase GeneModelingModern ManMolecularMolecular InteractionMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsMorbidityMorbidity - disease rateMutateMxi2Myeloid Differentiation-Inducing ProteinMyocardialMyocardial IschemiaMyocardial depressionMyocardial dysfunctionNCHSNF-kBNF-kappa BNF-kappaBNFKBNational Center for Health StatisticsNodalNon-Polyadenylated RNANuclear Factor kappa BNuclear Transcription Factor NF-kBObesityOxidative StressPRKM8PathogenesisPathologicPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPersonsPhasePhysiopathologyPilot ProjectsPlasmacytoma Growth FactorPlayPopulationPre-Clinical ModelPreclinical ModelsProblem SolvingProgressive DiseaseProliferatingProteinsProtocol ScreeningPublicationsRNARNA Gene ProductsRNA-Binding ProteinsRecombinant InterleukinsReperfusion TherapyReportingResearchResearch PersonnelResearchersRibonucleic AcidRibonucleoproteinsRoleSAP Kinase-1SAPK/JNKSAPK1 Mitogen-Activated Protein KinaseSAPK1/JNKSAPK2ASIS cytokinesScientific PublicationScientistServicesSignal TransductionSignal Transduction PathwaySignal Transduction SystemsSignalingSmokingStress-Activated Protein Kinase 2AStress-Activated Protein Kinase JNK1Stress-Activated Protein Kinase gammaSurvivorsT Helper FactorTLR4TLR4 geneTNF receptor-associated factor 3TRAF-3TRAF3TestingTherapeuticTissuesToll HomologueTranscription Factor AP-1Transcription Factor NF-kBTranscription Factor Proto-OncogeneTranscription factor genesTransgenic MiceTroponinUbiquitin Ligase Component GeneUbiquitin Ligase GeneUnited States National Center for Health StatisticsUniversitiesVascular Hypertensive DiseaseVascular Hypertensive DisorderVentricle RemodelingVentricular Cardiac RemodelingVentricular Myocardial RemodelingVentricular RemodelingVeteransWorkadiposityantagonismantagonistanti-inflammatory effectaortic valve replacementatheromatosisatherosclerotic diseaseatherosclerotic vascular diseasebiological signal transductionc-jun N-Terminal Kinasecardiac dysfunctioncardiac failurecardiac fibrosiscardiac hypertrophycardiac ischemiacardiomyocytecardiovascular disordercareercausationcell typechemoattractant cytokinechemokinechronic disorderco-morbidco-morbiditycomorbiditycoronary fibrosiscoronary ischemiacorpulencecysteine rich proteincytokinedevelopmentaldiabetesdisease causationefficacy testingfibrotic heartfunctional improvementgain of functiongene deletion mutationgp130 Transducer Chainheart disorderheart dysfunctionheart fibrosisheart ischemiahigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderimprove functionimprovedimproved functional outcomesin vivoinhibitorinjuriesinjury to the myocardiuminjury to tissueinterferon beta 2intervention researchinterventional researchinterventional studyinterventions researchinventionischemia injuryischemic injuryjun-NH2-Terminal Kinasekappa B Enhancer Binding Proteinknockin miceloss of functionlymphocyte activating factormRNAmembrane structuremigrationmilitary veteranmolecular modelingmortalitymouse modelmurine modelmyocardial fibrosismyocardial injurymyocardial ischemia/hypoxiamyocardial remodelingmyocardium ischemianecrocytosisneutralizing antibodynew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetnuclear factor kappa betaoverexpressoverexpressionp38p38 MAP Kinasep38 MAPK Genep38 Mitogen Activated Protein Kinasep38 Protein Kinasep38 SAPKp38-Alphap38Alphapathophysiologypatient oriented outcomespharmacologicpilot studyposttranscriptionalpressurepromoterpromotorreperfusionsexsmall molecular inhibitorsmall moleculesmall molecule inhibitorsocial rolestemstress-activated protein kinase 1therapeutic targettissue injurytoll-like receptor 4transcription factorubiquitin ligaseultrasoundveteran population
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ABSTRACT
Nearly 63 million people (20% of the US population) are eligible for VA benefits and services because
they are veterans, family members or survivors of veterans. Cardiovascular diseases (CVD) contribute to
significant morbidity and mortality of the military veterans and civilians (CDC/National Center for Health
Statistics). I have been…
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