grant
BLRD Research Career Scientist Award Application
Organization VETERANS HEALTH ADMINISTRATIONLocation PITTSBURGH, UNITED STATESPosted 1 Apr 2023Deadline 31 Mar 2030
VANIHUS FederalResearch GrantFY20253-methyl TTNEB9-cis-Retinoic Acid ReceptorATP-protein phosphotransferaseAccelerationAcquired brain injuryAcuteAffectAgingAgonistAlteplaseAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryApoplexyAreaAttentionAwardB cell growth factorB-Cell Differentiation Factor-1B-Cell Growth Factor-1B-Cell Growth Factor-IB-Cell Proliferating FactorB-Cell Stimulating FactorB-Cell Stimulating Factor-1B-Cell Stimulation Factor-1B-Cell Stimulatory Factor-1BBB disruptionBCDF-1BCGFBCGF-1BCSF 1BSF-1BSF1BexaroteneBinetrakinBiologicalBlood VesselsBody TissuesBrainBrain InjuriesBrain IschemiaBrain Nervous SystemBrain TraumaBrain Vascular AccidentCaringCell BodyCellsCerebral StrokeCerebrovascular ApoplexyCerebrovascular CirculationCerebrovascular StrokeChronicClinical TreatmentCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalCollaborationsDataDevelopmentDisturbance in cognitionED careER careEconomic BurdenElderlyEmergency CareEmergency Department careEmergency Room careEmergency health careEmergency medical careEncephalonFDA approvedFundingFutureGeneralized GrowthGenerationsGeneticGoalsGrantGrant ReviewGrowthHSP27HSPB1HSPB1 geneHealthHealth CareHealth systemHeat Shock 27 kD Protein 1Heat Shock 27kD Protein 1 GeneHeat Shock Protein 27Heat-Shock Protein 27 GeneHortega cellHospital AdmissionHospitalizationIL-4IL4 ProteinImmuneImmune responseImmune systemImmunesImmunityImpaired cognitionImpairmentInfiltrationInflammationInjuryInstitutionInterleukin-4Interleukin-4 PrecursorIntermediary MetabolismInvestigatorsIschemic Brain InjuryIschemic EncephalopathyIschemic StrokeJournalsKinase Family GeneLevel of EvidenceLong-term disabilityLymphocyte Stimulatory Factor 1MCGF-2MacrophageMagazineManuscriptsMast Cell Growth Factor-2Medical RehabilitationMedical centerMetabolic ProcessesMetabolismMiceMice MammalsMicrogliaMolecularMoodsMurineMusMφN-3 polyunsaturated fatty acidNINDSNational Institute of Neurological Diseases and StrokeNational Institute of Neurological Disorders and StrokeNational Institutes of HealthNatural regenerationNervous System PhysiologyNeurologicNeurologic functionNeurologicalNeurological functionOmega-3 Fatty AcidsOmega-3 PUFAOmega-3 Polyunsaturated Fatty AcidOmega3OutcomeOutcomes ResearchPTSDPaperPeer ReviewPersonal SatisfactionPhenotypePhylogenetic AnalysisPhylogeneticsPopulationPost-Traumatic NeurosesPost-Traumatic Stress DisordersPosttraumatic NeurosesProcessProtein KinasePublicationsQOLQOL improvementQuality of lifeRXRRXR ProteinRecombinant Tissue Plasminogen ActivatorRecoveryRecovery of FunctionRegenerationRegulatory T-LymphocyteRehabilitationRehabilitation therapyRejuvenationReportingResearchResearch PersonnelResearchersRetinoic Acid Receptor RXRRetinoid X ReceptorsRoleSafetyScientific PublicationScientistStrokeSurvivorsSynapsesSynapticSystemT-Cell Growth Factor 2T-Plasminogen ActivatorTBI recoveryTBI therapyTBI treatmentTargretinTestingTherapeuticThinkingTissue Activator D-44Tissue GrowthTissue Plasminogen ActivatorTissue-Type Plasminogen ActivatorTissuesTraumaTraumatic Brain InjuryTraumatic Brain Injury recoveryTregUnited States National Institutes of HealthUniversitiesVeteransWorkadult animaladult youthadvanced ageafter strokeagedaged animalaged animalsaged brainaging brainanimal old ageaxon damageaxon injuryaxonal damageaxonal injurybiologicblood flow in brainblood-brain barrier disruptionbloodbrain barrier disruptionbrain attackbrain blood circulationbrain blood flowbrain cellbrain damagebrain repairbrain tissuebrain-injuredcareercerebral blood flowcerebral circulationcerebral vascular accidentcerebrocirculationcerebrovascular accidentcerebrovascular blood flowclinical interventionclinical investigationclinical relevanceclinical therapyclinically relevantcognitive defectscognitive dysfunctioncognitive functioncognitive losscytokinedevelopmentaldisabilitydisabledeffective therapyeffective treatmentelderly animalfemale subjectsfunctional recoverygeriatricgitter cellglial activationglial cell activationglycogen synthase a kinasehost responsehydroxyalkyl protein kinaseimmune system responseimmunoresponseimprovedimprovements in QOLimprovements in quality of lifeindexinginjuriesinjury and repairinjury recoveryischemic brain damagelong-term recoverymalemature animalmesogliamicroglial cellmicrogliocytemilitary veterann-3 Fatty Acidsn-3 PUFAnervous system functionneurological recoverynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyold animalsomega-3omega-3sontogenyperivascular glial cellpharmacologicphosphorylase b kinase kinasepost strokepost-trauma stress disorderpoststrokeposttrauma stress disorderpre-clinicalpreclinicalprogramspsychiatric symptomquality of life improvementrecovery after TBIrecovery after injuryrecovery after traumatic brain injuryrecovery following injuryrecovery post injuryregenerateregulatory T-cellsrehab therapyrehabilitativerehabilitative therapyrepairrepair functionrepairedreparative functionresponserestorationsalt-inducible kinasesenior citizensocial rolesocio-economicsocio-economicallysocioeconomicallysocioeconomicsstroke modelstroke outcomestroke victimsstrokedstrokessubstantia albasynapset-PAthoughtstissue repairtraumatic brain damagetraumatic brain injury therapytraumatic brain injury treatmenttraumatic neurosistrial regimentrial treatmentvascularveteran populationwell-beingwellbeingwhite matterwhite matter injurywomen subjectsyoung adultyoung adult ageyoung adulthood♂
Description preview
Research in the Chen lab focuses on alleviating the neurological sequelae of traumatic brain injury (TBI) and
ischemic stroke, which diminish our veterans’ quality of life. Our goals are to help identify and/or develop
pharmacologic agents that can leverage phylogenetically conserved tissue-repair mechanisms to alleviate acute
and secondary brain…
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