grant
BLRD Research Career Scientist Award Application
Organization CENTRAL ARKANSAS VETERANS HLTHCARE SYSLocation NORTH LITTLE ROCK, UNITED STATESPosted 1 Apr 2019Deadline 31 Mar 2029
VANIHUS FederalResearch GrantFY2025ABCA1ABCA1 proteinATP binding cassette transporter 1AddressAdvanced Glycation End ProductsAdvanced Glycosylation End ProductsAffectAgingAgonistAmericanAnabolic AgentsAnabolismAntibodiesApoptosisApoptosis PathwayApproaches to preventionArchitectureAwardBindingBiochemistryBiological ChemistryBiologyBody TissuesBone DiseasesBone FormationBone Marrow Blood-Deriving CellBone Marrow Blood-Forming CellBone Marrow CellsBone MatrixBone RegenerationBone ResorptionBone callusBone remodelingBony CallusBook ChaptersCYBACYBA geneCallusCancer Cell GrowthCancersCartilageCartilaginous TissueCell BodyCell Communication and SignalingCell SignalingCellsCellular ExpansionCellular GrowthCholesterolClinicalClinical ManagementCollaborationsCommunitiesComplexCytochrome b Light ChainCytochrome b(-245), Alpha SubunitCytochrome b(558), Alpha SubunitDNA Molecular BiologyDeteriorationDiabetes MellitusDiagnosisDiseaseDisorderDistressDysfunctionEarly DiagnosisEndocrine Gland SecretionEndocrinologyEngineering / ArchitectureEnsureEpidemicExhibitsFDA approvedFamilyFractureFunctional disorderGene ExpressionGeneral PopulationGeneral PublicGenesGeneticGlucocorticoidsGlycosaminoglycansHDLDT1HealthHealth CareHealth Care CostsHealth CostsHigh PrevalenceHip FracturesHip Prosthesis ImplantationHistologyHormonesHospitalsHumanHydrogen OxideHypercalcemic Hormone of MalignancyHyperglycemiaIndividualIntracellular Communication and SignalingInvestigatorsJournalsKO miceKnock-out MiceKnockout MiceKnowledgeLifelong disabilityLigandsLigaseLigase GeneLiver X ReceptorMagazineMalignant CellMalignant NeoplasmsMalignant TumorMechanical StimulationMediatingMetabolism and EndocrinologyMiceMice MammalsMineralsModelingModern ManMolecularMolecular BiologyMolecular InteractionMorbidityMorbidity - disease rateMucopolysaccharidesMultiple MyelomaMurineMusMuscle WeaknessMuscular WeaknessMusculoskeletalMusculoskeletal DiseasesMusculoskeletal PainMusculoskeletal SystemNamesNational Academy of SciencesNull MouseOPGLOralOsteoclastic Bone LossOsteocytesOsteogenesisOsteopeniaOsteoporosisOsteoporosis preventionPTH Like Tumor FactorPTH genePTH-Like ProteinPTH-PTHrP ReceptorPTH-Related PeptidePTH-Related Peptide ReceptorPTH-Related Protein ReceptorPTH1 receptorPTHLP ReceptorPTHrPPTHrP ReceptorParathyrinParathyroid HormoneParathyroid Hormone Like Tumor FactorParathyroid Hormone ReceptorParathyroid Hormone Receptor 1Parathyroid Hormone Receptor Type IParathyroid Hormone-Like HormoneParathyroid Hormone-Like Peptide ReceptorParathyroid Hormone-Like ProteinParathyroid Hormone-Related PeptideParathyroid Hormone-Related Peptide ReceptorPathway interactionsPatientsPeer ReviewPermanent disabilityPersonsPhysiopathologyPlasma-Cell MyelomaPopulationPre-Clinical ModelPreclinical ModelsPrevention approachProgrammed Cell DeathPropertyProteinsPublishingRANKLReceptor SignalingRecombinant Parathyroid Hormone-Related ProteinResearchResearch PersonnelResearchersRoleScienceScientistSeminalSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSkeletonSynthetasesSystemTNFSF11TNFSF11 geneTechniquesTestingTherapeuticTherapeutic HormoneTherapeutic InterventionTissuesTumor Hypercalcemic FactorUnited States National Academy of SciencesVeteransVisitWalkingWaterWorkadvanced glycation endproductadvanced glycosylation endproductantagonismantagonistbiological signal transductionbiosynthesisbonebone cellbone disorderbone fracturebone fragilitybone healthbone lossbone massbone qualitybone repairbone strengthbone tissue formationcancer cellcareercell growthcholesterol-efflux regulatory proteinclinical investigationdiabetesdiabeticdiabetic patientearly detectionfracture riskfragility fractureglobal gene expressionglobal transcription profilehRANKL2hip arthroplastyhip joint replacementhip replacementhip replacement arthroplastyhormonal signalshormone signalshyperglycemicimprovedin vivoinhibitorinsightintervention therapylocomotor systemloss of functionmalignancymechanical loadmechanical stimulusmortalitymusculoskeletal disordermyelomamyelomatosisnamenamednamingnanostringneoplasm/cancernew approachesnon-diabeticnondiabeticnotchnotch proteinnotch receptorsnovelnovel approachesnovel strategiesnovel strategyp22 PHOXparathormoneparathyroid hormone-related proteinpathophysiologypathwaypharmacologicphrasespreventprevent osteoporosispreventingprogramsregenerate boneresearch studyrestorationsOdfscRNA sequencingscRNA-seqside effectsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskeletalskeletonssocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstandard of caretherapeutic agent developmenttherapeutic developmenttherapeutic targettooltranscriptometreatment effecttreatment strategy
Description preview
To ensure aging Veterans remain active and mobile with as little musculoskeletal pain as possible, new
approaches to the prevention of osteoporosis and promotion of timely bone regeneration following a fracture are
necessary. This collaborative research study brings together a group of VA investigators with diverse
perspectives, insights, models,…
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