grant
BLR&D Research Career Scientist Award
Organization OMAHA VA MEDICAL CENTERLocation OMAHA, UNITED STATESPosted 1 Oct 2019Deadline 30 Sept 2031
VANIHUS FederalResearch GrantFY2025ASGP-RAbsolute ethanolAddressAdmissionAdmission activityAffectAlcohol Chemical ClassAlcohol abuseAlcoholicAlcoholic Fatty LiverAlcoholic Liver DiseasesAlcoholsAmericanAnimal ModelAnimal Models and Related StudiesApoptoticAreaArmed Forces PersonnelAsialoglycoprotein ReceptorAsialoorosomucoid ReceptorAsialoorosomucoid-Binding ProteinAutophagocytosisAutophagosomeAwardBasic ResearchBasic ScienceBindingBiochemicalBiologyBook ChaptersBoozerCD66e AntigenCarcinoembryonic AntigenCarcinoembryonic Antigen-Related Cell Adhesion Molecule 5Cell BodyCellsCellular biologyCessation of lifeChronicClinicalCold-Insoluble GlobulinsCollaborationsCountryCytolysisDataDeathDefectDependent drinkerDestinationsDevelopmentDiseaseDisease ProgressionDisorderDysfunctionETOHEligibilityEligibility DeterminationEndocytosisEtOH abuseEthanolEthanol MetabolismEthyl AlcoholExocytosisExperimental DesignsFN1FamilyFibronectin 1FibronectinsFunctional disorderFundingGTP PhosphohydrolasesGTPasesGeneral PopulationGeneral PublicGoalsGolgiGolgi ApparatusGolgi ComplexGrain AlcoholGrant ReviewGuanosine Triphosphate PhosphohydrolasesGuanosinetriphosphatasesHealth CareHeavy DrinkingHepatic Asialoglycoprotein ReceptorHepatic CellsHepatic DisorderHepatic LectinHepatic Parenchymal CellHepatic TransplantationHepatocyteHepatotoxic effectHepatotoxicityImpairmentIn VitroIncidenceInjuryInjury to LiverInvestigationInvestigatorsJournalsLETS ProteinsLaboratoriesLarge External Transformation-Sensitive ProteinLigandsLinkLipidsLiverLiver Carbohydrate-Binding ProteinLiver CellsLiver GraftingLiver ToxicityLiver TransplantLiver diseasesLysisMagazineManuscriptsMeconium Antigen 100MediatingMedicalMedical centerMembraneMentorsMethylcarbinolMilitaryMilitary PersonnelMissionMolecular InteractionMonitorMonomeric G-ProteinsMonomeric GTP-Binding ProteinsMorphologyNAFLDNational Institutes of HealthOpsonic GlycoproteinOpsonic alpha(2)SB GlycoproteinOrganOrganellesPathogenesisPathway interactionsPatientsPeer ReviewPhysiologicPhysiologicalPhysiopathologyPlayProcessProductivityProgram DevelopmentProtein SecretionProtein TraffickingProteinsProtocol ScreeningPublishingReceptor ProteinRecyclingResearchResearch PersonnelResearchersRoleScientistSeminalSmall G-ProteinsSmall GTPasesSocietiesTherapeuticTherapeutic InterventionToxic effect on liver cellsToxinTrainingUnited States National Institutes of HealthVesicleVeteransWorkWorld Healthalcohol co-abusealcohol consequencesalcohol effectalcohol exposedalcohol exposurealcohol induced hepatic injuryalcohol induced liver disorderalcohol induced liver injuryalcohol metabolismalcohol problemalcohol related consequencesalcohol related liver diseasealcohol-associated liver diseasealcohol-induced hepatic dysfunctionalcohol-induced liver diseasealcohol-induced liver dysfunctionalcohol-mediated liver dysfunctionalcohol-mediated liver injuryalcohol-related liver diseasealcoholic liver injuryalpha 2-Surface Binding Glycoproteinautophagycarcinoembryonal antigencareercell biologychronic hepatic diseasechronic hepatic disorderchronic liver diseasechronic liver disorderconferenceconventiondevelop therapydevelopmentaldrink heavilyethanol abuseethanol effectethanol exposedethanol exposureethanol induced hepatic injuryethanol induced liver disorderethanol induced liver injuryethanol liver diseaseethanol-induced hepatic dysfunctionethanol-induced liver diseaseethanol-induced liver dysfunctionethanol-mediated liver dysfunctionethanol-mediated liver injuryexcessive alcohol consumptionexcessive alcohol ingestionexcessive alcohol intakeexcessive drinkingexcessive ethanol ingestionexposed to alcoholexposed to ethanolexposure to alcoholexposure to ethanolextreme drinkingfatty liver diseaseguanosinetriphosphatasehazardous alcohol useheavy alcohol usehepatic body systemhepatic damagehepatic diseasehepatic injuryhepatic organ systemhepatic toxicityhepatopathyhepatoxicityimprovedin vivoinjuriesinsightintervention developmentintervention therapyknowledge translationliver damageliver disorderliver injuryliver transplantationmembermembrane structuremilitary populationmilitary veteranmodel of animalnon-alcohol fatty liver diseasenon-alcoholicnon-alcoholic fatty liver diseasenon-alcoholic liver diseasenonalcoholicnonalcoholic fatty liver diseasenovelpathophysiologypathwaypopulation healthproblem alcohol useproblem drinkerproblem drinkingproblematic alcohol consumptionproblematic alcohol useprogramsprotein transportreceptorreceptor mediated endocytosisreceptor recyclingsocial rolesummitsymposiasymposiumtherapeutic agent developmenttherapeutic developmenttherapeutic targettherapeutically effectivetherapy developmenttraffickingtrans-Golgi Networktreatment developmentundergradundergraduateundergraduate studentuptakeveteran population
Description preview
The goal of my current VA work is to examine how ethanol exposure results in impaired function of the Golgi
apparatus. The Golgi apparatus (also called the Golgi body or Golgi complex) packages proteins into membrane
bound vesicles inside the cell before the vesicles are sent to their destination. As such, this organelle resides at
the…
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