grant
Blood vessel assembly from multipotent hemangioma-derived stem cells
Organization BOSTON CHILDREN'S HOSPITALLocation BOSTON, UNITED STATESPosted 1 Apr 2009Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20260-11 years oldATAC sequencingATAC-seqATACseqAnabolismAngiomaAreaAssay for Transposase-Accessible Chromatin using sequencingAtenololBasal Transcription FactorBasal transcription factor genesBenignBenign AngiomaBenign HemangiomaBindingBiological FunctionBiological ProcessBlood Vessel TumorBlood VesselsBreathingCausalityCell BodyCellsChIP SequencingChIP-seqChIPseqChildChild YouthChildren (0-21)CholesterolCholesterol HomeostasisChromatinClinicalClinical ManagementClinical ResearchClinical StudyCoupledDataData SetDehydrogenasesDiminished VisionDrug ModulationEndothelial CellsEndotheliumEnhancersEnzyme GeneEnzymesEquationEtiologyFTIFaceFarnesyl Transferase InhibitorFarnesyltransferase InhibitorsFoundationsFundingGene Down-RegulationGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene TranscriptionGene variantGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGenetic TranscriptionGenomeGenomicsGoalsGrowthHemangiomaHumanImplantInfantInfantile HemangiomaJuvenile HemangiomaLinkLocationLow VisionMediatingMedicalMiceMice MammalsModern ManMolecularMolecular InteractionMolecular ProbesMolecular TargetMurineMusNeoplasms in Vascular TissueNucleic Acid Regulator RegionsNucleic Acid Regulatory SequencesOperative ProceduresOperative Surgical ProceduresOutcomeOxidoreductaseOxidoreductase GenePartial SightPathologicPathway interactionsPatientsPost-Translational IsoprenylationPosttranslational IsoprenylationPre-Clinical ModelPreclinical ModelsPreclinical dataProcessProgenitor CellsPropanololPropranololProtein Farnesyltransferase InhibitorsProtein IsoprenylationProtein PrenylationRNA ExpressionRNA SeqRNA sequencingRNAseqReduced VisionReductasesRegulatory RegionsReporterResearchRespiratory AspirationRespiratory InspirationRiskSOX18SOX18 geneSRY-Box 18Signaling MoleculeStem Cell likeStrawberry AngiomaStrawberry BirthmarkStrawberry HemangiomaStrawberry MarkStrawberry nevusStructureSubnormal VisionSurgicalSurgical InterventionsSurgical ProcedureSurvey InstrumentSurveysTestingTherapeuticTipifarnibTissue GrowthTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionTranscription Factor Proto-OncogeneTranscription RepressionTranscription factor genesValidationVariantVariationVascular DiseasesVascular DisorderVascular NeoplasmsVascular Tissue TumorVascular TumorVasculogenicVisual impairmentXenograft Modelallelic variantanalyze gene expressionassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbase editingbeta-adrenergic receptorbiosynthesisblood vessel disorderblood vessel neoplasmcausationcholesterol metabolismchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcohortcompound repositioningcompound repurposingdiagnostic tooldisease causationdrug repositioningdrug repurposingdrug-sensitiveeffective therapyeffective treatmentenantiomerfacesfacialfarnesyl diphosphatefarnesyl pyrophosphatefarnesylpyrophosphatefeedinggene expression analysisgene expression assaygene regulatory networkgene repressiongenetic regulatory elementgenetic variantgenome editinggenomic editinggenomic variantimprovedin vitro activityin vivoinhibitorinspirationisoprenoidkidsmatrigelmevalonatemultipotencymultipotentnew therapeutic uses for existing drugsnew use of drugnew uses for an approved drugnew uses for existing drugsnovelontogenypathwaypharmacological repurposingpreclinical findingspreclinical informationprenylationpreventpreventingprogenitor capacityprogenitor cell differentiationprogenitor cell likeprogenitor differentiationprogenitor-likeprotein expressionrepositioning approved drugsrepositioning existing drugsrepurpose approved drugsrepurpose approved medicationrepurpose approved therapeuticrepurpose existing drugsrepurpose existing medicationrepurpose existing medicinerepurpose existing therapeuticsrepurpose existing therapiesrepurpose medicinerepurposingrepurposing a drugrepurposing agentrepurposing candidatesrepurposing established drugsrepurposing established medicationrepurposing existing pharmacological agentsrepurposing medicationrepurposing of already existing drugsrepurposing pharmaceuticalsresponseresponse to therapyresponse to treatmentscRNA sequencingscRNA-seqside effectsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmall molecular inhibitorsmall moleculesmall molecule inhibitorstem and progenitor differentiationstem cell characteristicsstem cell differentiationstem cellsstem-likestemnesssurgerytherapeutic repositioningtherapeutic repurposingtherapeutic responsetherapy responsetranscription factortranscriptional profilingtranscriptome sequencingtranscriptomic sequencingtranscriptomicstreatment responsetreatment responsivenessvalidationsvascularvascular dysfunctionvasculopathyvision impairmentvisually impairedxenograft transplant modelxenotransplant modelyoungsterβ-adrenergic receptor
Description preview
Abstract
Infantile hemangioma (IH) is an extraordinary example of vascular overgrowth wherein vessels
form rapidly over a year, then undergo a slow spontaneous involution that leaves behind a
fibrofatty residuum. IH is common: it occurs in 5% of infants, equating to ~183,200 infants/year
in the U.S. alone. 10-15% of IH will cause complications –…
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