grant
Blood Trauma, Vascular Remodeling, and Vasoregulation with Total Body Continuous Versus Pulsatile Artificial Circulation
NIHUS FederalResearch GrantFY2025Activities of Daily LivingActivities of everyday lifeAdverse ExperienceAdverse eventAlgorithmsApoplexyApoptosisApoptosis PathwayArchitectureArteriesBaroreceptor ReflexBaroreflexBleedingBloodBlood Reticuloendothelial SystemBlood flowBody TissuesBovine SpeciesBrain Vascular AccidentBrain hemorrhageCattleCell CoatCell-Extracellular MatrixCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeChronicCirculationClinicalCollagenCyclicityDataDevelopmentDevicesDiastolic HypertensionDysfunctionECMElastinEmergent TechnologiesEmerging TechnologiesEndotheliumEngineering / ArchitectureEventExerciseExtracellular MatrixFinancial costFrequenciesFunctional disorderGenerationsGlycocalyxGoalsHeart failureHemolysisHemorrhageHypertensionIn VitroInflammationIntermediary MetabolismInvestigationLVADLifeMaintenanceMechanical AspirationMetabolic ProcessesMetabolismModelingMorbidityMorbidity - disease rateMuscleMuscle TissueNerveOrthostatic HypotensionOxidative StressPathologicPatientsPeriodicityPhysiologicPhysiologicalPhysiologyPhysiopathologyPlatelet ActivationPostural HypotensionPostural adjustmentsPostural alterationsPostural changesProgrammed Cell DeathPulsatile FlowPulsatile PerfusionPulsating FlowPulse PressureQOL improvementRefractoryRhythmicityRistocetin CofactorRistocetin-Willebrand FactorSleepSpeedStrokeSuctionSuction DrainageThrombosisTissuesTraumaTunica MediaVascular Hypertensive DiseaseVascular Hypertensive DisorderVascular MediaVascular MediasVascular remodelingVasomotorarterial remodelingbleeding in brainblood lossblood pumpbovidbovinebrain attackcardiac failurecerebral vascular accidentcerebrovascular accidentcowdaily living functiondaily living functionalitydevelopmentalerythrolysisfunctional abilityfunctional capacitygastrointestinalhemocompatibilityhemodynamicshemorrhagic strokehigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderimprovedimprovements in QOLimprovements in quality of lifein vivoinsightleft ventricular assist devicemonetary costmortalitymuscularpathophysiologypressurepreventpreventingquality of life improvementstrokedstrokesthrombotic diseasethrombotic disordertotal artificial heartvon Willebrand Factorvon Willebrand Protein
Description preview
Project Abstract
Left ventricular assist device support is standard therapy for patients with advanced, life-threatening heart failure.
However, current-generation impeller-based blood pumps have introduced a new “non-pulsatile” physiology with
frequent adverse events. Lack of pulsatility contributes to blood trauma, endothelial and arterial…
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