grant
Blood Biomarker Development and Validation in Chronic Traumatic Encephalopathy and Alzheimer's Disease and Alzheimer's Disease Related Dementias
Organization BOSTON UNIVERSITY MEDICAL CAMPUSLocation BOSTON, UNITED STATESPosted 1 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY202521+ years old3-D3-Dimensional3DAD dementiaAD detectionAD related dementiaADRDAPOE e4APOE-ε4APOEε4AccelerationAddressAdoptionAdultAdult HumanAgeAgreementAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer disease detectionAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's and related dementiasAlzheimer's biomarkerAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's detectionAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease biological markerAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimers DementiaAlzheimer’s biological markerAlzheimer’s disease biomarkerAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAntigenic DeterminantsArmed Forces PersonnelAstroproteinAutopsyAβBinding DeterminantsBiological MarkersBloodBlood BanksBlood PlasmaBlood Reticuloendothelial SystemBlood VesselsBody TissuesBostonBrainBrain ConcussionBrain Health RegistryBrain Nervous SystemCerebral ConcussionCessation of lifeClinicClinicalCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCollectionCommotio CerebriCraniocerebral InjuriesCraniocerebral TraumaDataDeathDetectionDiagnosisDiagnosticDiagnostics ResearchDiseaseDisorderDisturbance in cognitionDoseEncephalonEnrollmentEpidemiologyEpitopesExposure toFemaleFootballFoundationsFrequenciesGFA-ProteinGFAPGeneticGlial Fibrillary Acid ProteinGlial Fibrillary Acidic ProteinGlial Intermediate Filament ProteinGoalsGrantGroups at riskHead InjuriesHead TraumaImpaired cognitionIndividualInfrastructureInternetKnowledgeLesionLifeLightLiteratureMT-bound tauManufactured footballMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMediatingMedicalMemoryMilitaryMilitary PersonnelNINDSNational Institute of Neurological Diseases and StrokeNational Institute of Neurological Disorders and StrokeNerve CellsNerve DegenerationNerve UnitNeural CellNeurocyteNeuron DegenerationNeuronsOutcomePETPET ScanPET imagingPETSCANPETTParticipantPathologicPathologyPeople at riskPersonsPersons at riskPhlebotomyPhosphorylation SitePhotoradiationPlasmaPlasma SerumPlayPopulation HeterogeneityPopulations at RiskPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary Senile Degenerative DementiaProbabilityProteinsRaceRacesRad.-PETRegistriesResearchResearch ResourcesResourcesReticuloendothelial System, Serum, PlasmaRiskRisk FactorsSamplingSeveritiesSiteSpecificitySurvey InstrumentSurveysSynapsesSynapticSyndromeTestingTimeTissuesTraumatic encephalopathyUnited States Department of Veterans AffairsUnited States Veterans AdministrationUniversitiesVenous blood samplingVeterans AdministrationVeterans AffairsViolenceWWWWomana beta peptideabetaadulthoodagesalzheimer riskamyloid betaamyloid-b proteinapo E-4apo E4apo epsilon4apoE epsilon 4apoE-4apoE4apolipoprotein E epsilon 4apolipoprotein E-4apolipoprotein E4beta amyloid fibrilbio-markersbiologic markerbiomarkerbiomarker developmentbiomarker validationbrain atrophybrain basedcerebral atrophychronic traumatic encephalopathycognitive assessmentcognitive dysfunctioncognitive losscognitive testingcollision sportsconcussionconcussivecontact sportscortical atrophydementeddensitydepositorydiagnostic criteriadiverse populationsdosageenrollepidemiologicepidemiologicalexecutive controlexecutive functionhead impactheterogeneous populationinfancyinfantilemarker validationmenmicrotubule bound taumicrotubule-bound taumid lifemid-lifemiddle agemiddle agedmidlifemilitary populationmilitary servicemilitary veterannecropsyneural degenerationneurobehavioralneurodegenerationneurodegenerativeneurofilamentneurological degenerationneuronalneuronal degenerationnon-dementednondementedp-taup-τphospho-tauphospho-τphosphorylated taupopulation diversitypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypost-translational modification of taupostmortemposttranslational modification of tauprimary degenerative dementiaracialracial backgroundracial originrecruitrepositoryresponsesenile dementia of the Alzheimer typesexsoluble amyloid precursor proteinsub concussionsub concussivesubconcussionsubconcussivesurveillance studysynapsetautau Proteinstau factortau phosphorylationtau posttranslational modificationtau-1three dimensionaltimelinevascularveteran populationviolentviolent behaviorwebworld wide webτ Proteinsτ phosphorylation♀
Description preview
Each year, millions of people are exposed to repetitive head impacts (RHI) through contact sports, military
service, and physical violence. These impacts can confer risk for Alzheimer’s disease (AD) and related
dementias (ADRD) including chronic traumatic encephalopathy (CTE). The unique pathological lesion of CTE
includes phosphorylated tau…
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